Athletics vs San Francisco Giants Picks and Prediction for Thursday June 25 2026

By: Kim Smith Published 06/25/2026, 12:30 AM ET
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The Athletics travel across the Bay to face the San Francisco Giants at Oracle Park in San Francisco, California, on Thursday, June 25, 2026. First pitch is scheduled for 3:45 PM with coverage available on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

The Athletics are expected to send Jeffrey Springs to the mound. Springs enters this game with a 3-7 record, a 5.55 ERA, and a 1.35 WHIP across 82.2 innings. He has allowed 85 hits while striking out 72 batters, walking 27, and surrendering 21 home runs. San Francisco is scheduled to counter with Landen Roupp, who owns a 5-7 record, a 4.15 ERA, and a 1.29 WHIP over 80.1 innings. Roupp has allowed 71 hits, struck out 89 batters, walked 33, and given up five home runs. Based on the numbers provided, San Francisco holds the advantage in the starting pitching matchup.

Athletics Looking to Reverse Recent Results

The Athletics enter Thursday's contest with a 38-41 record and a solid 20-18 road mark. Despite being below .500 overall, they have played better away from home than many teams with similar records. However, the Athletics have lost three of their last five games, including a 3-1 defeat to San Francisco in the opener of this series. Their recent victories came against the Angels, while the other losses also came against Los Angeles.

Offensively, the Athletics have produced respectable numbers this season. They are batting .248 with 365 runs scored, 669 hits, and 105 home runs. The club owns a .328 on-base percentage and a .417 slugging percentage. On the pitching side, the Athletics have posted a 4.98 ERA and a 1.45 WHIP while allowing opponents to hit .264 against them. Their staff has recorded 662 strikeouts and issued 304 walks.

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The most obvious strength for the Athletics is power production. Their 105 home runs lead the comparison between these two clubs and have helped generate more runs than San Francisco despite a similar batting average. If the Athletics can capitalize on their power advantage, they could quickly change the complexion of this game.

Giants Hoping to Build on Recent Victory

San Francisco comes into this matchup with a 32-46 overall record and a 15-20 record at home. The Giants have struggled for much of the season, but they picked up a 3-1 victory over the Athletics in their most recent game. That win snapped a stretch in which San Francisco had lost three straight contests against Miami. Their other recent victory came against Atlanta.

The Giants are batting .258 as a team with 320 runs, 693 hits, and 82 home runs. They have produced a .310 on-base percentage and a .419 slugging percentage. On the mound, San Francisco owns a 4.40 ERA and a 1.38 WHIP. Opponents are batting .250 against Giants pitching, while the staff has accumulated 615 strikeouts and 300 walks.

The strength for San Francisco entering this contest is its overall pitching advantage. The Giants have a lower ERA, a lower WHIP, and a lower opponent batting average than the Athletics. Combined with the stronger numbers from their starting pitcher, that gives the home team a favorable foundation heading into Thursday afternoon.

Athletics vs San Francisco Giants Picks and Prediction

Athletics vs San Francisco Giants Pick

  • Pick: San Francisco Giants Moneyline

San Francisco holds the edge in both team pitching statistics and the starting pitching matchup. The Giants also won the first game of the series and have the advantage in batting average. While the Athletics have generated more power throughout the season, the overall pitching profile favors San Francisco in this matchup.

Athletics vs San Francisco Giants Total Pick

  • Take the over if the total is set at 8.0.

I would lean toward the over if the total is set at 8.0 because the Athletics have allowed a .264 opponent batting average and carry a team ERA near five. Their starter has also allowed 21 home runs this season. Both offenses have shown the ability to produce extra-base hits, which could help push the scoring upward.

Final Score Prediction: San Francisco Giants 6 – Athletics 4

This prediction was written before the completion of game play on Wednesday.

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