Athletics vs St. Louis Cardinals Picks and Prediction for Wednesday, September 3, 2025
In the final game of a three-game interleague series, the Athletics are taking on the St. Louis Cardinals inside Busch Stadium on Wednesday evening in our Athletics vs. Cardinals prediction. This article is being written ahead of Tuesday’s game. The Athletics are fifth in the AL West with a 64-75 record and are sending left-hander Jeffrey Springs to the mound. The Cardinals are fourth in the NL Central with a 68-71 record and have young lefty Matthew Liberatore getting the ball. Need some winners this baseball season? Check out our Free MLB Picks.
Athletics Building to the Offseason
The Athletics are looking to continue playing well after their 11-3 road win against the St. Louis Cardinals on Monday. The lineup was able to go 15-for-40 with three walks and six strikeouts on the day as JJ Bleday (x2) and Zack Gelof homered on the day. The Athletics went 6-for-17 with runners in scoring position and stranded six men on base. Luis Morales secured the victory as he pitched 5.2 innings and allowed two runs.
The Athletics are sending southpaw Jeffrey Springs to pitch and he is holding his own as in 28 games (26 starts), he is 10-9 in 151.0 innings with a 4.17 ERA and a 1.19 WHIP. He has been able to limit the amount of hits as he is posting a .232 batting average against. Springs faced the Cardinals once as a member of the Tampa Bay Rays in a loss as he pitched five innings and gave up four runs on six hits with one hit by pitch, three walks, and three strikeouts.
Injury Report for Athletics
- Pitcher Ben Bowden: Lat (OUT)
- Pitcher Joey Estes: Back (OUT)
- Pitcher Jacob Lopez: Flexor (OUT)
- Pitcher Jack Perkins: Shoulder (OUT)
- Catcher Austin Wynns: Abdomen (OUT)
- Pitcher Jose Leclerc: Shoulder (OUT)
- Center fielder Denzel Clarke: Abductor (OUT)
- Third baseman Max Muncy: Hand (OUT)
- Pitcher Grant Holman: Shoulder (OUT)
- Pitcher Gunnar Hoglund: Hip (OUT)
- Pitcher Luis Medina: Elbow (OUT)
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Cardinals Fighting for the Postseason
The St. Louis Cardinals are looking to bounce back after Monday’s 11-3 home loss against the Athletics in their most recent game. The Cardinals were able to go 8-for-35 with one walk and 12 strikeouts at the plate. St. Louis finished 2-for-7 with runners in scoring position while leaving seven men on base. Sonny Gray struggled in the loss as he allowed seven runs in six innings.
Young left-hander Matthew Liberatore is going to be taking the mound for the Cardinals in this game and has been holding his own as he is 6-11 with a 4.32 ERA and a 1.32 WHIP in 131.1 innings over 25 starts. He has been struggling a bit in terms of keeping the ball in the park as he has allowed 16 so far after giving up 11 in 86.0 innings last season. Liberatore pitched against the Athletics once last season out of the bullpen and did not factor into the decision as he gave up zero runs on one hit with one walk and zero strikeouts in 1.2 innings.
Injury Report for St. Louis
- Catcher Yohel Pozo: Concussion (OUT)
- First baseman Alex Burleson: Wrist (OUT)
- Pitcher John King: Back (OUT)
- Second baseman Brendan Donovan: Groin (OUT)
- Third baseman Nolan Arenado: Shoulder (OUT)
- Pitcher Zack Thompson: Lat (OUT)
Athletics ML (4 units)
The road/home splits show a gap between what these pitchers have been able to do as Jeffery Springs is 5-5 with a 3.66 ERA and a .217 opposing batting average in 78.2 innings (15 road games, 14 starts) while Matthew Liberatore is 4-5 with a 4.55 ERA and a 1.28 WHIP in 59.2 innings (11 home starts) up to this point. There is a bit of a difference between these offenses in terms of hitting with runners in scoring position, as the Athletics are 12th with a .760 team OPS in those chances, while the Cardinals are tied with the Houston Astros for 20th with a .720 team OPS with runners in scoring position. All in all, go with the Athletics to secure the victory here.
Over (5 units)
These pitchers are not doing too well in their previous seven starts as Jeffrey Springs is 2-2 with a 4.14 ERA and a 1.11 WHIP in 37.0 innings while Matthew Liberatore is 0-4 with a 4.94 ERA and a 1.55 WHIP in 31.0 innings during that stretch. Both teams are doing well offensively when looking at the batting average of balls in play, as the Athletics are ninth with a .299 team batting average of balls in play while the Cardinals are 12th with a .294 team BABIP up to this point. Go with the over as the better bet in this game.
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