Athletics vs. St. Louis Cardinals Picks and Prediction, Tuesday, September 2, 2025
The Athletics are facing off against the Cardinals in game two of their series at Busch Stadium in St. Louis, Missouri; keep reading for our Athletics versus Cardinals Prediction. The Athletics are last in the AL West with a record of 64-75. St. Louis is fourth in the NL Central with a record of 68-71. The Cardinals had a record of 2-1 against the Oakland Athletics in 2024. The first pitch is scheduled for 7:45 p.m. EDT.
Athletics’ Offense Finds A Win
The Athletics are coming off a win on Monday versus the Athletics with a final score of 11-3. This win would break up a three-game losing streak the Athletics had amassed after being swept by the Rangers. The Athletics are out of the playoff race and hope to focus on building a strong pitching core to match their impressive offense.
We have seen the Athletics perform well at the plate this season as they rank 11th overall in runs and fourth overall in batting average at .254 and slugging percentage at .434. The Athletics have done a great job in generating runs however, they have been unable to counter their poor pitching for most of the season. The Athletics are 28th in ERA this season at 4.82, 29th in home runs, and 28th in walks.
Right-handed pitcher Luis Severino will be starting for the Athletics on Tuesday.
Luis Severino:
- has a record of 6-11 with an ERA of 4.82 and 103 strikeouts in 24 appearances this season.
- has given up 9 runs on 9 hits with 3 walks and 2 strikeouts in 4 innings versus the Cardinals in his career.
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Cardinals’ Pitching Falling Apart
The Cardinals pick up a loss on Monday versus the Athletics with a final score of 11-3. This loss would be the first of their lengthy home stand as they look to boost their record before the season ends. St. Louis is out of the wild card race as they face too many obstacles to reach it at this point.
St. Louis this season has shared the woes of the mound with the Athletics as they also rank at the bottom of the league in pitching. The Cardinals are 21st overall in ERA at 4.30, however, the Cardinals are seventh in home runs and fifth in walks allowed. This has been a key difference to the Athletics as the Cardinals have been able to suppress their opposition from generating multiple base hits however, they struggle with allowing consistent hits as they sit 27th in hits this season.
Right-handed pitcher Miles Mikolas will be taking the mound for the Cardinals on Tuesday.
Miles Mikolas:
- is 6-10 with an ERA of 5.04 and 86 strikeouts in 26 appearances this season.
- has a record of 0-1 with an ERA of 9.00 and 5 strikeouts in 2 appearances against the Oakland Athletics in his career.
Athletics Money Line (-102) (4 units)
The Cardinals have a 3-7 record in their last 10 games versus the Athletics at home. The Athletics have a record of 7-3 as underdogs in their last 10 games on the road. Neither team is fighting for wins as both sit out of the playoff race. This is going to come down to who can take advantage of the other’s poor pitching. Much like we saw in game one of this series, I believe the Athletics should be capable of dominating the Cardinals with their superior offense.
I am taking the Athletics on the Money Line.
Over 8.5 (-104 ) (4 units)
The Athletics have an over/under record of 6-2 in their last 8 games. The Cardinals have an over/under record of 6-3-1 in their last 10 games. The Athletics alone can take us over this total much like they did in game one. The Cardinals are struggling at the plate and should allow quite a few runs to the dominating offense of the Athletics. However the Athletics’ pitching has also struggled and should be met with equal troubles coming from the Cardinals’ batting.
I am siding with the over at 8.5.
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