Atlanta Braves vs. Detroit Tigers Picks and Prediction for Sunday, September 21, 2025
In the closing game of a three-game interleague series, the Atlanta Braves are taking on the Detroit Tigers inside Comerica Park on Sunday afternoon in our Braves vs. Tigers prediction. The Braves are looking for the sweep after a 6-5 road win on Saturday. The Braves are fourth in the NL East with a 71-83 record and are sending young right-hander Spencer Strider to the mound. The Tigers are first in the AL Central with an 85-69 record and have righty Casey Mize getting the ball. Dial in your read with MLB picks for Atlanta Braves vs. Detroit Tigers before first pitch.
Braves Playing Spoiler
The Atlanta Braves are looking to continue building momentum to end the season as they were able to secure a 6-5 road win over the Detroit Tigers on Saturday. The lineup was able to go 7-for-33 with six walks and six strikeouts on the day. Nacho Alvarez Jr (x2) and Drake Baldwin hit home runs, while Ronald Acuna Jr stole a base. The Braves went 2-for-6 with runners in scoring position and stranded six men on base. Joey Wentz did not factor into the decision as he pitched five innings and gave up a pair of runs.
The Braves are sending young righty Spencer Strider to pitch, and he is struggling. As in 21 starts, he is 6-13 in 114.1 innings with a 4.64 ERA and a 1.36 WHIP. He has had trouble limiting the number of home runs, as he has given up 19 already after allowing 22 in 186.2 innings in 2023. Strider last faced the Tigers in 2023 as he recorded the win by throwing five innings and giving up five runs on seven hits with one hit by pitch, two walks, and six strikeouts.
Injury Report for Atlanta
- Pitcher Aaron Bummer: Shoulder (OUT)
- Right fielder Jake Fraley: Oblique (OUT)
- Catcher Sean Murphy: Hip (OUT)
- Pitcher Daysbel Hernandez: Shoulder (OUT)
- Third baseman Austin Riley: Abdominal (OUT)
- Pitcher Grant Holmes: Elbow (OUT)
- Pitcher Spencer Schwellenbach: Elbow (OUT)
- Pitcher AJ Smith-Shawver: Calf/Elbow (OUT)
- Pitcher Reynaldo Lopez: Shoulder (OUT)
- Pitcher Joe Jimenez: Knee (OUT)
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Tigers Ice Cold Lately
The Detroit Tigers are looking to bounce back after Saturday’s 6-5 home loss against the Atlanta Braves in their most recent game. The Tigers were able to go 9-for-35 with a pair of walks and 11 strikeouts at the plate as Zach McKinstry and Spencer Torkelson each hit a home run. Detroit was 1-for-4 with runners in scoring position while leaving six men on base. Keider Montero was not able to provide much length as he threw three innings and gave up three runs without factoring into the decision.
Right-hander Casey Mize is going to be taking the mound for the Detroit Tigers in this game and has been doing well as he is 14-5 with a 3.88 ERA and a 1.28 WHIP in 137.0 innings over 26 starts. His command this year has been the best we have seen in his career as he has 33 walks to 126 strikeouts thus far. Mize faced Atlanta once last season in a loss as he allowed two runs on five hits with zero walks and three strikeouts in four innings on the bump.
Injury Report for Detroit
- Second baseman Colt Keith: Rib Cage (OUT)
- Pitcher Sawyer Gipson-Long: Neck (OUT)
- Pitcher Beau Brieske: Forearm (OUT)
- Center fielder Matt Vierling: Oblique (OUT)
- Pitcher Reese Olson: Shoulder (OUT)
- Pitcher Sean Guenther: Hip (OUT)
- Pitcher Jackson Jobe: Flexor (OUT)
- Pitcher Jason Foley: Shoulder (OUT)
- Pitcher Alex Cobb: Hip (OUT)
- Pitcher Ty Madden: Shoulder (OUT)
Atlanta Braves vs. Detroit Tigers Pick
Spread Pick for Braves vs. Tigers
- Atlanta Braves ML (4 units)
There is such a thing as momentum, and the Braves coming back and scoring three runs in the final two innings to win Saturday certainly gives them an advantage. Especially with the Tigers being ice cold right now and just finding different ways to lose over the last week. There has been a slight difference with how these starting pitchers have done in September thus far as Spencer Strider is 1-1 with a 3.00 ERA and a .234 opposing batting average in 18.0 innings (three starts) while Casey Mize is 2-0 with a 3.31 ERA and a 1.04 WHIP in 16.1 innings (three starts) up to this point. The Braves have won seven of the eight games against the Tigers dating back to the 2023 season, so go with the Atlanta Braves to secure a win and the sweep.
Over/Under Pick for Braves vs. Tigers
- Over (4 units)
Both starting pitchers have been getting rocked during the previous seven starts, as Spencer Strider is 1-5 with a 6.63 ERA and a 1.66 WHIP in 36.2 innings, while Casey Mize is 4-1 with a 4.91 ERA and a 1.25 WHIP in 36.2 innings during that stretch. During the last 15 days, these pitching staffs have been struggling as the Braves are 24th in baseball with a 4.89 team ERA (14 games) while the Tigers are 21st with a 4.60 team ERA (13 games) during that stretch. These teams have had the over hit in seven of their last 10 games against one another, so go with the over to hit here.
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