Baltimore Orioles vs Los Angeles Angels Picks and Prediction for Monday June 22 2026

By: Kim Smith Published 06/22/2026, 01:20 AM ET
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The Baltimore Orioles and Los Angeles Angels meet at Angel Stadium in Anaheim, California on Monday, June 22, 2026, with first pitch scheduled for 9:38 PM ET. The game will be televised on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Baltimore is expected to start Kyle Bradish in this matchup. Bradish enters with a 4-7 record, a 4.00 ERA, and a 1.51 WHIP across 81.0 innings. He has allowed 81 hits while striking out 85 batters, issuing 41 walks, and surrendering 11 home runs.

Los Angeles is expected to counter with Sam Aldegheri. Aldegheri comes into the game with a 2-2 record, a 4.50 ERA, and a 1.55 WHIP over 20.0 innings. He has allowed 20 hits while recording 13 strikeouts, issuing 11 walks, and giving up 2 home runs.

Baltimore Looking to Build on a Big Road Win

The Orioles enter Monday's contest with a 36-42 overall record and a 14-23 mark on the road. Baltimore has won two of its last five games, recently defeating Los Angeles Dodgers once and Seattle once. The Orioles also suffered losses to Los Angeles Dodgers once and Seattle twice during that stretch. Their most recent game was a 3-2 victory over the Dodgers, giving Baltimore some momentum heading into this series.

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Baltimore owns a .239 team batting average with 357 runs scored, 622 hits, and 90 home runs. The Orioles have posted a .319 on-base percentage and a .397 slugging percentage. Their pitching staff carries a 4.50 ERA and a 1.39 WHIP while allowing opponents to hit .258. Baltimore pitchers have recorded 607 strikeouts and issued 276 walks.

One strength for Baltimore is its ability to generate power and run production. The Orioles have scored more runs than the Angels and have nearly matched them in home runs. While the road record has been a challenge, the offensive numbers remain competitive entering this matchup.

Angels Hope to Carry Momentum Home

The Angels come into Monday's game with a 31-47 overall record and a 17-20 record at home. Los Angeles has won two of its last five games, recently defeating the Athletics once and Arizona once. The Angels also lost three games during that stretch, including one against Arizona and two against the Athletics. Their most recent outing was a convincing 7-0 victory.

Los Angeles has compiled a .239 batting average with 352 runs scored, 629 hits, and 92 home runs. The Angels own a .319 on-base percentage and a .399 slugging percentage. Their pitching staff has produced a 4.63 ERA and a 1.43 WHIP while allowing opponents to hit .238. Angels pitchers have recorded 673 strikeouts and issued 362 walks.

The Angels' biggest advantage is their ability to generate strikeouts. Los Angeles has recorded 673 strikeouts, well ahead of Baltimore's total. They have also collected more hits and slightly more home runs. However, their pitching staff has struggled with walks throughout the season.

Baltimore Orioles vs Los Angeles Angels Picks and Prediction

Baltimore Orioles vs Los Angeles Angels Pick

  • Pick: Baltimore Orioles Moneyline

Baltimore enters this matchup with the edge in the matchup predictor and holds slight advantages in runs scored and overall pitching performance. The Orioles also come into the game after defeating one of the stronger teams on their schedule. With a lower ERA and WHIP than Los Angeles, Baltimore gets the nod in what appears to be a competitive matchup.

Baltimore Orioles vs Los Angeles Angels Total Pick

  • Pick: Take the over if the total is set at 8.5

I would lean toward the over if the total is set at 8.5. Both teams have scored more than 350 runs this season and have combined for 182 home runs. The starting pitchers enter with ERAs of 4.00 and 4.50, while both bullpens carry season ERAs above 4.50. Those numbers suggest scoring opportunities for both sides.

Final Score Prediction: Baltimore Orioles 6 – Los Angeles Angels 5

This prediction was written before the completion of game play on Sunday.

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