Baltimore Orioles vs San Diego Padres Picks and Prediction for Tuesday, September 2, 2025
In the middle game of a three-game interleague series, the Baltimore Orioles are taking on the San Diego Padres inside Petco Park on Tuesday night in our Orioles vs. Padres prediction. This is being written ahead of Monday’s game. The Orioles are fifth in the AL East with a 61-76 record and are sending right-hander Tyler Wells to the mound. The Padres are second in the NL Central with a 76-61 record and have veteran righty Yu Darvish getting the ball. Don’t go down on strikes!
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Orioles Looking to be Competitive in September
The Baltimore Orioles are looking to recover after their 13-2 road loss against the San Francisco Giants on Sunday. The lineup was able to go 10-for-35 with six walks and 10 strikeouts on the day as Jackson Holliday stole a base. Baltimore went 2-for-12 with runners in scoring position and stranded 12 men on base. Tomoyuki Sugano struggled in the loss as he allowed seven runs in 3.1 innings of work.
The Orioles are sending right-hander Tyler Wells to the mound and he is making his 2025 debut after undergoing Tommy John surgery last year. Last season, he struggled as he only made three starts and was 0-2 with a 5.87 ERA and a 1.37 WHIP in 15.1 innings. This will be the first time in Wells’ career that he will be facing the Padres so it will be an interesting test.
Injury Report for Baltimore
- Pitcher Brandon Young: Hamstring (OUT)
- Pitcher Scott Blewitt: Elbow (OUT)
- Second baseman Jordan Westburg: Ankle (OUT)
- Pitcher Felix Bautista: Shoulder (OUT)
- Catcher Gary Sanchez: Knee (OUT)
- Catcher Adley Rutschman: Oblique (OUT)
- Pitcher Zach Eflin: Back (OUT)
- Right fielder Tyler O’Neill: Wrist (OUT)
- Pitcher Grayson Rodriguez: Elbow (OUT)
- Pitcher Colin Selby: Hamstring (OUT)
- Shortstop Jorge Mateo: Elbow (OUT)
- Pitcher Albert Suarez: Shoulder (OUT)
- Pitcher Tyler Wells: Elbow (OUT)
Padres Looking to Stay in NL West Race
The San Diego Padres are looking to bounce back after Sunday’s 7-2 road loss against the Minnesota Twins in their most recent game. The Padres were able to go 8-for-35 with a pair of walks and nine strikeouts at the plate as well. San Diego finished 3-for-14 with runners in scoring position while leaving nine men on base. David Morgan was used as an opener as he pitched two shutout innings without factoring into the decision.
Veteran righty Yu Darvish is going to be taking the mound for the Padres in this game and has been struggling as he is 3-4 with a 5.66 ERA and a 1.11 WHIP in 47.2 innings (10 starts). He has limited the amount of hits against him as he has a .217 batting average against thus far. Darvish last faced the Orioles in 2023 as he lost the start by going seven innings and allowed four runs on eight hits with one walk and six strikeouts.
Injury Report for San Diego
- Shortstop Xander Bogaerts: Foot (OUT)
- Center fielder Jackson Merrill: Ankle (OUT)
- Pitcher Michael King: Knee (OUT)
- Pitcher Jhony Brito: Forearm (OUT)
- Pitcher Joe Musgrove: Elbow (OUT)
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San Diego Padres ML (5 units)
Tyler Wells is a bit of a wild card, being his first start of the season coming off Tommy John surgery, while Yu Darvish is 2-1 with a 2.95 ERA and a .153 batting average against in 21.1 innings (four home starts) so far. There is a significant gap from the performance of these bullpens as the Orioles are 25th in the sport with a 4.66 reliever ERA, while the Padres are best in baseball with a 3.10 bullpen ERA this year. San Diego is the superior team this season so go with the San Diego Padres to win this game at home.
Over (4 units)
During their previous 13 games heading into this matchup, these teams are scoring well. Baltimore is averaging 4.46 runs per game in that stretch while San Diego is scoring 5.15 runs per game. When expanding that to the last 15 games, these teams are not killing rallies by hitting into double plays. The Orioles are tied with a handful of teams with 13 double plays hit into while the Padres are tied with three other teams for 18th place with 19 double plays committed. The over has hit in each of the previous three games against one another, so take the over to hit as well.
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