Boston Red Sox vs Arizona Diamondbacks Picks and Prediction for Sunday, September 7, 2025
The Boston Red Sox (78-64, 71-68-3 O/U) will be taking on the Arizona Diamondbacks (71-71, 67-66-9 O/U) on Sunday afternoon in the final game of a three-game interleague series for our Red Sox vs. Diamondbacks prediction. This article is being written ahead of Saturday’s game. Young right-hander Brayan Bello (11-6, 3.07 ERA) is going to be pitching in this game for the Red Sox while the Diamondbacks are sending righty Ryne Nelson (7-3, 3.57 ERA) to the hill. Today’s edge: MLB predictions for Boston Red Sox vs Arizona Diamondbacks with form and matchup notes.
Red Sox Looking to Get AL East Crown
The Boston Red Sox are doing a solid job as they are third in the AL East with a 78-64 record up to this point. The Red Sox are hitting at a strong level as they are eighth in the bigs with a .749 team OPS while averaging 4.91 runs per game.
The Boston Red Sox are coming off a 10-5 road loss against the Arizona Diamondbacks on Friday as Trevor Story stole a base. Payton Tolle struggled as he allowed five runs in three innings of work to record the loss.
Left fielder Jarren Duran (.781 OPS, 22 SB) has been stepping up at the top of the Red Sox lineup this season. Young right-hander Brayan Bello (11-6, 3.07 ERA) will be taking the mound and secured the win over the Cleveland Guardians last time out as he pitched five innings and gave up three runs on six hits with three walks and four strikeouts.
Injury Report for Boston
- Pitcher Jordan Hicks: Shoulder (OUT)
- Right fielder Roman Anthony: Oblique (OUT)
- Third baseman Marcelo Mayer: Wrist (OUT)
- Pitcher Richard Fitts: Biceps (OUT)
- Right fielder Wilyer Abreu: Calf (OUT)
- Pitcher Luis Guerrero: Elbow (OUT)
- Pitcher Tanner Houck: Flexor (OUT)
- Pitcher Hunter Dobbins: Knee (OUT)
- Pitcher Liam Hendriks: Hip (OUT)
- Pitcher Josh Winckowski: Elbow (OUT)
- First baseman Triston Casas: Knee (OUT)
- Pitcher Kutter Crawford: Knee (OUT)
- Pitcher Patrick Sandoval: Elbow (OUT)
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Diamondbacks Looking to Keep Winning
The Arizona Diamondbacks are looking to continue improving with their young players as they are fourth in the NL West with a 71-71 record up to this point. The offense is hitting at an excellent level as they are fifth in baseball with a .250/.323/.437 team slash line while averaging 4.94 runs per game.
The Arizona Diamondbacks are coming off Friday’s 10-5 home win against the Boston Red Sox as they were 5-for-11 with runners in scoring position. Eduardo Rodriguez recorded the win as he pitched six innings and allowed one run against his former team.
Second baseman Ketel Marte (25 HR, .916 OPS) continues to be one of the best second basemen in the sport. Right-hander Ryne Nelson (7-3, 3.57 ERA) is going to be on the mound and is coming off a no-decision against the Texas Rangers, where he allowed three runs on four hits with one walk and seven strikeouts in six innings.
Injury Report for Arizona
- First baseman Pavin Smith: Quadriceps (OUT)
- Left fielder Lourdes Gurriel Jr: Knee (OUT)
- Pitcher Anthony DeSclafani: Thumb (OUT)
- Pitcher Kevin Ginkel: Shoulder (OUT)
- Pitcher Tommy Henry: Elbow (OUT)
- Pitcher Christian Montes De Oca: Elbow (OUT)
- Pitcher Justin Martinez: Elbow (OUT)
- Pitcher Christian Mena: Shoulder (OUT)
- Pitcher Corbin Burnes: Elbow (OUT)
- Pitcher A.J. Puk: Elbow (OUT)
- Pitcher Blake Walston: Elbow (OUT)
Boston Red Sox vs. Arizona Diamondbacks Pick
Spread Pick for Boston Red Sox vs. Arizona Diamondbacks
- Arizona Diamondbacks -116 (5 units)
Throughout the season, Brayan Bello and Ryne Nelson are pitching at a similar level so it will be interesting to see the other factors of this game be the difference. During the previous 14 games, these teams are scoring at a bit of a different level to one another. Boston is scoring 4.5 runs per game in that stretch while Arizona is averaging 5.14 runs per game. The pitching in that same stretch also shows a difference as the Red Sox are pitching to a 4.39 team ERA while the Diamondbacks are posting a 3.53 team ERA in that span. The Diamondbacks won each of the previous five games against the Red Sox so take the Arizona Diamondbacks to end the series with a win.
Over/Under Pick for Boston Red Sox vs. Arizona Diamondbacks
- Over (4 units)
Both teams are holding their own at the plate with runners in scoring position as the Red Sox are 12th with a .761 team OPS in those chances, while the D-Backs are 15th with a .751 team OPS with runners in scoring position. Over the season, these teams have hit for power as Boston is 13th in baseball with 169 total home runs, while Arizona is fourth with 197 themselves. The over has hit in three of the last four games between these teams, so take the over as well.
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