Boston Red Sox vs. Toronto Blue Jays and Prediction, Tuesday, September 23, 2025

By: Jason Raffoul Updated 09/23/2025, 10:52 AM ET
red sox vs. blue jays prediction
Use Code SSWC

On Saturday afternoon, the Boston Red Sox and Toronto Blue Jays meet in the first game of a three-game series at Rogers Center, and we will set you up with a Red Sox vs. Jays prediction to go along with free picks. Lucas Giolito will pitch for the Sox while Kevin Gausman throws for the Blue Jays. Read on for a prediction on the score and a game breakdown. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.

Red Sox Clinging to the Wild Card

Entering the off day on Monday, the Red Sox are slotted into the second wild card spot in the American League, with a one-game lead on Houston and Cleveland. Lucas Giolito will toe the rubber in the first game of this series with Toronto.

  • He did not factor into the decision in last Wednesday's game against the Athletics, allowing four runs on five hits and five walks while striking out five over 4.1 innings.
  • Giolito worked around steady traffic early and stranded six runners through four frames to limit the damage to one run, but it caught up to him in the fifth. After a single and two walks loaded the bases with one out, the right-hander was removed from the game, and all three inherited runners came around to score.
  • The rough outing broke a four-start streak in which Giolito had posted a 1.46 ERA and 22:10 K:BB across 24.2 innings.
  • Giolito eclipsed the 140-inning mark in the outing, which automatically converts his $14 million club option for 2026 into a $19 million mutual option and almost guarantees that he will become a free agent this upcoming offseason.

Gausman Takes the Mound in Key Series

Kevin Gausman will take the hill in the first game of this divisional set. Gausman did not factor into the decision Wednesday against the Rays, allowing one run on six hits and two walks while striking out six over six innings.

  • Gausman gave up an early run in the first inning but quickly settled in, ousting 18 of the next 22 batters while shutting out Tampa Bay the rest of the way.
  • Coming off a complete-game shutout against Houston in which he allowed just two hits, the right-hander continued his dominant form last week, though Toronto's lack of run support left him with a no-decision.
  • Gausman has now given up only three runs across his last four starts (30 innings), posting a 0.90 ERA and 28:4 K:BB during that span.

Entering play Monday, the Blue Jays hold a two-game lead on the New York Yankees for first place in the AL East. They have been dominant at Rogers Centre, recording a 50-25 mark. Toronto is ripping the baseball in the second half, recording the most runs after the break and an .802 post-All-Star game OPS. They can put a stranglehold on the division with a good showing here.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that StatSalt may use third-party services to process my data.

Red Sox vs. Blue Jays Game Pick

Money Line Pick for Red Sox vs. Blue Jays

  • Toronto Blue Jays -1.5 (4 units)

Kevin Gausman has been one of the best pitchers in the American League this season. Last week, he completed six innings for the 11th time in 12 starts since the All-Star break. He surrendered a run-scoring single in the opening inning but managed to silence Tampa Bay’s lineup. He’ll carry a strong 3.38 ERA, 1.01 WHIP, and 177/47 K/BB ratio across 183 2/3 innings over 30 starts into this game against Boston, who have lost four of their last five games against Toronto. Home has been friendly to the Jays, who have a dominant 50-25 record at Rogers Centre. Take Toronto by two.

OVER/UNDER PICK for Red Sox vs. Blue Jays

  • UNDER (4 units)

We talked about how dominant Kevin Gausman has been for the Blue Jays, but Lucas Giolito has been a surprisingly strong contributor for the Red Sox this season. Excluding last week’s setback, where he allowed five walks, he had a strong four-start stretch in which he had posted a 1.46 ERA and 22:10 K:BB across 24.2 innings. Toronto has been involved in a number of low-scoring contests lately. The total has gone under in 11 of their last 16 games. I like Gausman and Giolito to deliver strong performances, and this game to go under.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Review
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Review
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
Fanatics

10 x $100 bet match in FanCash

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer Fanatics Review
Cashable No
>

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.