Chicago Cubs vs. Atlanta Braves Picks and Predictions, Wednesday September 10, 2025

By: Nathan Smith Published 09/10/2025, 10:15 AM ET
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The final stretch of the 2025 MLB season is here. While not all games have meaning for both teams, there's still plenty of competitive baseball being played, especially in our Chicago Cubs vs. Atlanta Braves prediction.

The Chicago Cubs (82-63) have been playing consistent baseball all season long, and with a postseason spot close to being locked up, they're looking to find momentum over the final few weeks of the 2025 campaign.

On Wednesday, they take on the Atlanta Braves (65-80), a team that has been hampered by injury and inconsistency this season. Throughout it all, 2025 will be remembered as a year of major disappointment for a recent postseason threat. Read on to see our Chicago Cubs vs. Atlanta Braves prediction.

Expected pitching matchup: RHP Jameson Taillon vs. LHP Chris Sale.

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Can the Cubs keep building momentum towards the post-season?

The Chicago Cubs have been one of baseball's most consistent teams thus far in 2025, and with a fantastic 38-35 record away from home this season, they've put themselves in a spot to come through the regular season as the top Wild Card team in the National League. This year for the Cubs has been all about scoring runs, with the team ranking seventh in baseball in total runs scored, and with a team ERA of 3.89 on the season, they've done well to balance out an incredibly talented roster.

On the mound for Chicago here will be veteran righty Jameson Taillon, who has put together a respectable 4.15 ERA through 19 starts this season, with the 33-year-old set to post the lowest WHIP of his career thus far with a mark of 1.08. Last time out for the Cubs was a big win over these Braves, with Cade Horton tossing 6.1 innings of one-run ball as Pete Crow-Armstrong and Matt Shaw each knocked in two runs on the night, enough to pick up the 6-1 victory.

Can Atlanta find some positives to take out of the 2025 campaign?

The Atlanta Braves came into 2025 knowing it could be a tough campaign, and with the team putting up a 35-36 record at home this season, they find themselves in the very unfamiliar spot in fourth place in the National League East. As a pitching staff, the Braves have struggled to a 4.45 team ERA this season, and while the Braves offense has been solid, ranking 15th in total runs this season just hasn't been good enough to help this team find any sort of consistency throughout the season.

Atlanta will turn to veteran star Chris Sale in this one, as he has posted a stellar 2.38 ERA over 17 starts this year, once again being impossible for hitters to pick up as he's struck out 132 hitters over just 102.1 innings of work. Last time out for the Braves was a tough loss to these Cubs, with the lineup managing just one run on four hits on the night as the team wasted a six-inning, two-run outing from Spencer Strider to fall 6-1 in this matchup.

Chicago Cubs vs. Atlanta Braves Pick

Spread Pick for Cubs vs. Braves

  • Atlanta -105 (4 units)

While the Chicago Cubs have clearly been the superior team in this matchup thus far in 2025, the Braves will have one of the best pitchers in the league taking the mound in this one, giving them a major advantage heading into the series finale.

In Sale's last start against the Cubs, it was the Braves that came away winners 7-0, and with a record of 2-2 in their last four head-to-head matchups in Atlanta, expect the Braves to lean on that pitching to lead them to a win here.

Over/Under pick For Chicago Cubs vs. Atlanta Braves

  • Under 9 (4 units)

In the last 10 head-to-head encounters between these teams, the under is 8-2, with four of their five meetings thus far in 2025 seeing a total of seven or less runs scored, with less than eight total runs scored in their past four games played in Atlanta.

For the Cubs, the under comes in at 6-4 in their last 10 overall games, with five or less runs allowed in eight games during that span, and for the Braves, the under sits at 7-3 in their past 10, with an average of just 3.2 runs scored per game in that stretch.

Keep it simple, take the under.

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