Chicago White Sox vs Cleveland Guardians Picks and Prediction for Saturday October 10 2026

A spot in the American League Championship Series will be up for grabs when the Chicago White Sox battle the Cleveland Guardians. The game is scheduled for Saturday October 10th 2026 at 8:00 pm EST. Progressive Field in Cleveland, Ohio will be the scene and TBS will provide coverage. The Guardians are a -138 favorite and the total has been set at 7. Be sure to check out our free MLB picks for more MLB predictions throughout the postseason.

Chicago Comfortable on the Road

The Chicago White Sox took the first two games of this best-of-five series on the road and are looking to win their first playoff series since 2005. The White Sox won seven of their last ten games to close the regular season and finished nine games below .500 on the road. On Thursday, Chicago batters went 1-for-7 with runners in scoring position and left 12 men on base during a 9-5 home loss versus Cleveland. 3B Miguel Vargas homered and drew three walks for the White Sox. 

Chicago manager Will Venable has not named a starting pitcher for this matchup. His most likely option would be Sean Burke (11-7 3.34 ERA), who allowed one run across five plus frames in a 4-3 Game Two victory. Through 54 innings this postseason, the White Sox have limited opponents to a .199 OBA and registered 52 strikeouts.

During the regular season, Chicago ranked 10th in the majors with a .726 OPS and fifth with 776 runs scored. The White Sox clubbed 211 home runs, but have hit just four long balls through their first six postseason contests. 1B Munetaka Murakami (35), 3B Miguel Vargas (33), and SS Colson Montgomery (31) are all members of the 30 home run club.

Cleveland Needs to Pitch Well to Advance

The Ckleveland Guardians have reached the postseason in seven of their previous ten years and are looking to make their first World Series appearance since 2016. The Guardians won eight of ten games to conclude the regular season and finished one-game ahead of the White Sox to capture the AL Central Division crown. In Game Four, Cleveland erupted for six runs in the sixth inning to even this series at two games apiece. 3B Jose Ramirez went 2-for-5 with a home run and three RBIs for the Guardians. 

Cleveland skipper Stephen Vogt has not announced a starting pitcher for Game Five. Like the White Sox, the Guardians will employ an all hands on deck approach. Twenty-seven year old righty Gavin Williams (14-8 3.76 ERA) was used to close Thursday’s victory and will be unlikely to go more than two innings in this contest. In this series (36 IP), the Guardians have allowed just two home runs and fanned an impressive 54 batters. 

Cleveland has to pitch well, because their offense finished 26th in the majors in OPS and 24th in runs scored. The Guardians hit 162 home runs in 162 regular season games, which put them near the bottom of the majors in that category. Seven players finished with double digit home run totals, but Jose Ramirez (12 HR) is counted on to deliver the big hit.

Chicago White Sox vs Cleveland Guardians Picks and Prediction

Pick: Chicago White Sox +118

Chicago limited Cleveland to three runs in the first two games of this series, but their pitching let them down in two close out games at home. The White Sox have more pop in their lineup and appear to be a team of destiny this season. Take Chicago to win on the road and move on to the American League Championship Series.

Pick: Over 7 (-125)

The forecast calls for the temperature to be in the 60s with a 12 mph wind blowing out to left field. In winner-take-all-games, often one big swing of the bat can be the difference. The White Sox have more options that can deliver that blow and the Guardians might have made a mistake by using Gavin Williams to close Game Four. Take the over.

Final Score Prediction: Chicago White Sox 6-3