Chicago White Sox vs Minnesota Twins Picks and Prediction for Friday August 28 2026
The Chicago White Sox travel to Target Field in Minneapolis, Minnesota, to face the Minnesota Twins on Friday, August 28, 2026. First pitch is scheduled for 8:10 p.m. ET, with coverage on MLB.TV. Chicago enters at 70-63 overall and 29-36 on the road, while Minnesota is 64-70 overall and 35-31 at home. At the time of this writing the odds were not released. Before placing any wagers, check out our free MLB picks for more baseball predictions and analysis.
Starting Pitchers
Chicago is expected to start Luis Castillo, who enters at 4-10 with a 5.19 ERA and 1.42 WHIP across 118 innings. He has allowed 130 hits while striking out 105 and walking 37, with 21 home runs surrendered. Minnesota is expected to counter with Dean Kremer, who is 2-4 with a 5.22 ERA and 1.18 WHIP through 58.2 innings. He has allowed 50 hits while recording 58 strikeouts and 19 walks, with 14 home runs allowed. Neither starter brings strong run-prevention numbers into this matchup, making both offenses important factors Friday night.
White Sox Carry Momentum Into Minnesota
Chicago enters Friday at 70-63 and sits atop the AL Central. The White Sox have won two straight games, beating Texas 11-7 and 10-4, and they are 3-2 over their last five contests.
The White Sox are batting .239 as a team with 641 runs, 1,070 hits and 178 home runs. They carry a .320 on-base percentage and .411 slugging percentage. On the mound, Chicago has posted a 4.16 ERA and 1.31 WHIP, while opponents are batting .241.
Chicago's biggest edge is offensive production. The White Sox have scored more runs and hit considerably more home runs than Minnesota this season. They also lead the season series 4-3, giving them another reason for confidence heading into this divisional matchup.
Twins Looking to Stop a Two-Game Slide
Minnesota enters at 64-70 after consecutive losses to the Athletics, falling 4-2 and 7-4. The Twins are just 1-4 over their last five games, with their lone victory coming in a 9-6 win.
Minnesota is batting .245 with 615 runs, 1,108 hits and 155 home runs. The Twins own a .319 on-base percentage and .405 slugging percentage. Their pitching staff has struggled more than Chicago's, carrying a 4.69 ERA and 1.39 WHIP, while opponents are batting .254.
The Twins do have a solid 35-31 home record, but recent form is a concern. Minnesota has allowed at least four runs in four straight games and now faces a Chicago offense that just scored 21 runs across its last two contests.
Chicago White Sox vs Minnesota Twins Picks and Prediction
Pick: Chicago White Sox Moneyline
Chicago is the side pick. The White Sox are playing better baseball right now, own the stronger overall record and have the more productive offense. Minnesota's home record keeps this from being an easy matchup, but the Twins have lost four of their last five and own the weaker season-long pitching numbers. With Chicago entering on a two-game winning streak and sitting atop the division, take the Chicago White Sox moneyline.
Pick: Over 8.5
The total isn't available at the time of writing, but take the Over if the number is set at 8.5. Both projected starters carry ERAs above 5.00, while Chicago has scored 21 runs over its last two games. Minnesota's pitching staff owns a 4.69 ERA, and the White Sox staff has also been vulnerable enough to give the Twins opportunities. With both sides capable of producing offense against these starting profiles, nine or more runs is a reasonable target.
Final Picks: Chicago White Sox Moneyline and Over 8.5 if available.
This preview was completed before play on Thursday. Starting pitchers, betting lines and other game information are subject to change before the game begins.