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Chicago White Sox vs Minnesota Twins Picks and Prediction for Wednesday June 3 2026

By: Kim Smith Published 06/03/2026, 05:20 AM ET
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The Chicago White Sox and Minnesota Twins meet on Wednesday, June 3, 2026, at Target Field in Minneapolis, Minnesota. First pitch is scheduled for 1:40 PM ET with coverage available on ESPN Unlmtd and MLB.TV. At the time of this writing the odds were not released. Chicago enters the game with a 32-28 record, while Minnesota comes in at 28-33. The White Sox have been one of the better teams in the division despite their road struggles, while the Twins are looking to build on a recent victory in this series. Be sure to check out our free MLB picks.

The White Sox are expected to start Erick Fedde on Wednesday afternoon. Fedde enters the contest with an 0-5 record, a 5.40 ERA, and a 1.48 WHIP over 53.1 innings. He has allowed 56 hits while striking out 34 batters and surrendering 13 home runs. Minnesota will counter with Taj Bradley, who has put together a strong season so far. Bradley owns a 5-1 record with a 3.21 ERA and a 1.21 WHIP across 56 innings. He has allowed 47 hits, struck out 65 batters, walked 21 batters, and given up six home runs.

Chicago Looking to Regain Winning Form

The White Sox enter this matchup with a 32-28 overall record and a 12-17 record on the road. Chicago had won four consecutive games before falling 9-6 to Minnesota in the most recent meeting. During that successful stretch, the White Sox recently won over Detroit three times and also defeated Minnesota by a 6-2 score. Four victories in their last five games show that Chicago has still been playing quality baseball despite the recent setback.

Offensively, the White Sox are batting .239 while scoring 281 runs on 473 hits. Chicago has been one of the stronger power-hitting teams in this matchup, producing 83 home runs while carrying a .323 on-base percentage and a .410 slugging percentage. On the mound, the White Sox own a 4.28 ERA and a 1.30 WHIP while holding opponents to a .235 batting average. Their pitching staff has recorded 485 strikeouts and issued 229 walks.

The biggest strength for Chicago is its power production. The White Sox have hit 83 home runs, significantly more than Minnesota's 65. They also own the higher slugging percentage and a slightly better opponent batting average, showing the ability to impact games both offensively and on the mound.

Minnesota Aiming to Build Momentum at Home

Minnesota enters Wednesday's contest with a 28-33 overall record and a 16-14 mark at Target Field. The Twins recently snapped a four-game losing streak with a 9-6 victory over Chicago. Prior to that win, Minnesota suffered consecutive losses to Pittsburgh and also fell to the White Sox. While the recent results have been mixed, the Twins now have an opportunity to secure another home victory.

The Twins are batting .236 as a team while scoring 284 runs on 482 hits. Minnesota has collected 65 home runs along with a .317 on-base percentage and a .386 slugging percentage. Their pitching staff owns a 4.56 ERA and a 1.36 WHIP while allowing opponents to hit .249. Minnesota has issued 219 walks and recorded 482 strikeouts.

One area where Minnesota holds an advantage is overall run production. Despite the lower batting average and fewer home runs, the Twins have scored 284 runs compared to Chicago's 281. Minnesota has also collected more hits, showing an ability to consistently put runners on base and generate offense through multiple avenues.

Chicago White Sox vs Minnesota Twins Picks and Prediction

Chicago White Sox vs Minnesota Twins Pick

  • Pick: Minnesota Twins Moneyline

Minnesota enters this game with a significant edge in the starting pitching matchup. Bradley owns a 5-1 record with a 3.21 ERA, while Fedde enters with an 0-5 record and a 5.40 ERA. The Twins are also coming off a victory in the most recent meeting between these clubs. While Chicago has played well recently, the starting pitching advantage makes Minnesota the preferred side.

Chicago White Sox vs Minnesota Twins Total Pick

  • Pick: Take the over if the total is set at 8.5

I would look toward the over because both teams have demonstrated the ability to score runs. Chicago has produced 281 runs and 83 home runs this season, while Minnesota has scored 284 runs. The most recent matchup finished with 15 combined runs, and both teams enter with ERAs above 4.00. Those numbers point toward offensive opportunities throughout the game.

Final Score Prediction: Minnesota Twins 6 – Chicago White Sox 4

This prediction was written before the completion of game play on Tuesday.