Chicago White Sox vs Minnesota Twins Picks and Prediction for Wednesday, September 3, 2025
The Chicago White Sox (50-88, 63-67-8 O/U) will be taking on the Minnesota Twins (62-75, 64-67-6 O/U) on Wednesday evening in the third game of a four-game American League Central series for our White Sox vs. Twins prediction. This article is being written ahead of Tuesday’s game. Rookie right-hander Yoendrys Gomez (3-2, 5.20 ERA) is going to be pitching in this game for the White Sox, while the Twins are sending young righty Zebby Matthews (4-4, 5.06 ERA) to the hill. Need some winners this baseball season? Check out our Free MLB Picks.
White Sox Looking for Improvement
The Chicago White Sox are doing a poor job as they are fifth in the AL Central with a 50-88 record up to this point. The White Sox are hitting at a brutal level as they are 28th in the bigs with a .676 team OPS while averaging 3.93 runs per game.
The Chicago White Sox are coming off a 6-5 road loss against the Minnesota Twins on Monday as Colston Montgomery and Chase Meidroth each hit a home run. Fraser Ellard was the opener and did not factor into the decision as he allowed an unearned run in 1.2 innings.
Second baseman Lenyn Sosa (.727 OPS, 18 HRs) has been the best hitter in their lineup and needs to continue stepping up as the year wraps up. Rookie right-hander Yoendrys Gomez (3-2, 5.20 ERA) will be taking the mound and lost against the New York Yankees, where he pitched 4.0 innings and gave up five runs (four earned) on two hits with six walks and six strikeouts.
Injury Report for Chicago
- Third baseman Miguel Vargas: Hand (OUT)
- Center fielder Luis Robert Jr: Hamstring (OUT)
- Pitcher Elvis Peguero: Elbow (OUT)
- Pitcher Owen White: Hip (OUT)
- Pitcher Dan Altavilla: Lat (OUT)
- Pitcher Miguel Castro: Knee (OUT)
- Pitcher Drew Thorpe: Elbow (OUT)
- Pitcher Prelander Berroa: Elbow (OUT)
- Pitcher Ky Bush: Elbow (OUT)
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Twins Looking Towards the Future
The Minnesota Twins are looking to continue improving with their young players as they are fourth in the AL Central with a 62-75 record up to this point. The offense is hitting at a respectable level as they are tied with the Cincinnati Reds and Miami Marlins for 17th in baseball with a .238/.311/.397 team slash line while averaging 4.22 runs per game.
The Minnesota Twins are coming off Monday’s 6-5 home loss against the Chicago White Sox as they were 1-for-7 with runners in scoring position. Bailey Ober did not factor into the decision as he pitched five innings and gave up four runs.
Center fielder Byron Buxton (29 HR, 21 SB) has been clicking at the plate and continues to be a solid hitter when healthy. Young right-hander Zebby Matthews (4-4, 5.06 ERA) is going to be on the mound and is coming off a win over the San Diego Padres, where he threw six innings and gave up three runs (two earned) on seven hits with zero walks and three strikeouts.
Injury Report for Minnesota
- Left fielder Alan Roden: Thumb (OUT)
- Catcher Christian Vazquez: Shoulder (OUT)
- Pitcher Anthony Misiewicz: Shoulder (OUT)
- Pitcher David Festa: Shoulder (OUT)
- Pitcher Pablo Lopez: Shoulder (OUT)
Chicago White Sox ML (4 units)
Since the All-Star break, these pitchers are performing on two different levels as Yoendrys Gomez is 2-1 with a 3.86 ERA and a .176 batting average against in 18.2 innings (four starts) while Zebby Matthews is 3-3 with a 4.99 ERA and a 1.49 WHIP in 39.2 innings (eight starts) during that stretch. In that same time offensively, they have been performing at two completely different levels as Chicago is eighth with a .760 team OPS while Minnesota is 19th with a .712 team OPS in that stretch. The White Sox have won four of the last five games against the Twins, so take the Chicago White Sox to secure the victory here.
Over (5 units)
During the last seven outings for both pitchers, they are giving up runs as Yoendrys Gomez is 2-1 with a 4.50 ERA and a 1.36 WHIP in 22.0 innings (four starts) while Zebby Matthews is 3-2 with a 4.29 ERA and a 1.40 WHIP in 35.2 innings (seven starts) in that stretch. These bullpens, over the course of the seaso,n have struggled as well. The White Sox are 18th in the majors with a 4.15 reliever ERA while the Twins are 24th with a 4.43 bullpen ERA right now. All in all, go with the over as the better bet to make for this game.
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