Chicago White Sox vs St. Louis Cardinals Picks and Prediction for Sunday September 13 2026

The Chicago White Sox visit the St. Louis Cardinals at Busch Stadium in St. Louis, Missouri, on Sunday, September 13, 2026. First pitch is scheduled for 2:15 PM ET with coverage on MLB.TV. Chicago enters at 75-72 overall and 32-41 on the road, while St. Louis is 73-75 overall and 35-38 at home. The Cardinals won the series opener 7-3, extending Chicago's losing streak to four games. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

Chicago is scheduled to start Sean Burke, who enters at 8-7 with a 3.58 ERA and 1.20 WHIP across 156.0 innings. He has allowed 131 hits and 18 home runs while recording 169 strikeouts against 56 walks. St. Louis counters with Michael McGreevy, who is 6-9 with a 3.92 ERA and 1.25 WHIP through 154.0 innings. He has surrendered 151 hits and 20 home runs while striking out 106 and walking 42. Chicago has the statistical advantage in the starting matchup, particularly in ERA, WHIP, strikeouts and hits allowed.

Chicago Looks to End a Four-Game Losing Streak

Chicago enters Sunday at 75-72 overall and 32-41 away from home. The White Sox have dropped four consecutive games and are 1-4 over their last five. They lost the series opener in St. Louis 7-3 after being swept in a three-game set by Pittsburgh by scores of 2-0, 4-2 and 9-3. Their lone victory during the five-game stretch was a convincing 10-1 win over Minnesota. Despite the slump, Chicago remains above .500 and entered the weekend at the top of the AL Central.

The White Sox are batting .235 with 688 runs, 1,161 hits and 192 home runs. They have posted a .318 on-base percentage and .405 slugging percentage. On the pitching side, Chicago owns a 4.15 ERA and 1.31 WHIP while holding opponents to a .242 batting average. The staff has recorded 1,211 strikeouts against 523 walks, while the White Sox are 30-29 in day games.

Chicago's most notable advantage in this matchup is its power. The White Sox have hit 192 home runs compared with only 156 for St. Louis, and their .405 slugging percentage also exceeds the Cardinals' .386 mark. Chicago additionally owns the better team ERA, WHIP and opponent batting average. The concern is current form, as the White Sox have scored only eight runs during their four-game losing streak and need their offense to rediscover the production shown in their most recent victory.

St. Louis Tries to Build on the Series Opener

St. Louis enters this matchup at 73-75 overall and 35-38 at Busch Stadium. The Cardinals are 2-3 over their last five games after snapping a three-game losing streak with Friday's 7-3 victory over Chicago. Before that win, St. Louis dropped three straight games at San Francisco by scores of 7-6, 2-1 and 5-4 in 11 innings. The Cardinals' other victory during the five-game stretch was a 10-8 road win.

The Cardinals are batting .244 with 675 runs, 1,220 hits and 156 home runs. They carry a .317 on-base percentage and .386 slugging percentage. St. Louis has produced a 4.30 team ERA and 1.35 WHIP while opponents are batting .255. The pitching staff has 1,167 strikeouts against 507 walks, and the Cardinals are 26-32 during day games.

St. Louis has the better batting average and has collected more hits than Chicago, but several of the broader numbers favor the visitors. The Cardinals trail the White Sox in runs, home runs and slugging percentage while also carrying the weaker ERA, WHIP and opponent batting average. St. Louis does have the momentum advantage after winning the opener, but Sunday's matchup appears considerably more balanced when the season-long numbers and starting pitching are considered.

Chicago White Sox vs St. Louis Cardinals Picks and Prediction

Pick: Chicago White Sox Moneyline

The Chicago White Sox Moneyline is the preferred side. Chicago's four-game losing streak makes this a difficult team to back on recent form alone, but the White Sox have several meaningful statistical advantages. They have the better scheduled starting-pitching numbers, more power, a higher slugging percentage and the stronger overall pitching metrics. St. Louis took the opener, but Chicago has the profile to respond in Sunday's matchup and avoid another series loss.

Pick: Under 8.5

Take the Under if the total is set at 8.5 or higher. Both scheduled starters enter with ERAs below 4.00 and WHIPs of 1.25 or lower, giving this matchup the potential for a relatively controlled first half. Chicago has scored three runs or fewer in each game during its four-game losing streak, while St. Louis was held to six or fewer runs in four of its last five games. At 8.5 or better, the pitching matchup provides enough value to lean toward the Under.

Final Picks: Chicago White Sox Moneyline and Under 8.5

This preview was completed on Saturday. Starting pitchers, betting lines and other game information are subject to change before the game begins.