Chicago White Sox vs. Washington Nationals Picks and Prediction, Saturday, September 27, 2025
An interleague matchup goes down on Saturday, September 27 at 4:05 p.m. ET as the Chicago White Sox take on the Washington Nationals, so continue reading for our White Sox vs. Nationals prediction. This is written before Friday's game has ended.
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White Sox Swept by Yankees
Chicago enters play on Friday with a record of 58-101 as the White Sox are coming off being swept by the New York Yankees. Chicago is hitting .231, which ranks 27th, while on the road, they are hitting .232. In the month of September, the White Sox are hitting .220. No batter on Chicago has faced Irvin in their MLB careers.
The White Sox are set to start right-hander Sean Burke, who's 4-11 with a 4.29 ERA in 27 games, including 22 starts. Last time out, he went four innings, allowing 2 runs against the Padres. This will be his first career start against the Nationals. Chicago has a team ERA of 4.25, which ranks 21st.
Nationals Starting Irvin
Washington is 65-94 and coming off a series loss to the Atlanta Braves. The Nationals are set to start right-hander Jake Irvin, who's 9-13 with a 5.69 ERA in 32 starts this season. Last time out, he went 5.1 innings, allowing 2 runs against the Mets. He has never faced the White Sox in his career. Washington has a team ERA of 5.34, which ranks 29th.
The Nationals offensively are hitting .242, which ranks 21st. At home this season, Washington is hitting .241, while in the month of September, the Nationals are hitting .237. No batter on Washington gas faced Burke in the majors.
White Sox vs. Nationals Pick
- Nationals ML (5 units)
The Nationals and White Sox have nothing to play for in the final series, but this is still a good spot for Washington to get the win. Irvin has pitched well this season and will be able to limit the White Sox offense, which has struggled all season long. Chicago's bullpen is also an issue, as the White Sox will give up some late runs to help Washington get the big win here.
Take the Nationals ML.
Over/Under Pick for White Sox vs. Nationals
- Under (4 units)
Although Washington has been one of the better over teams this season, the under is the way to go here. Burke and Irvin should both be able to go 5 innings and only give up a couple of runs, as this seems like a 5-2 type of win for the Nationals who add some runs late. Washington has gone under 7 runs in three of their last four games, while the White Sox have gone under 8 runs in three of their last four.
Take the under here.