Cincinnati Reds vs Chicago White Sox Picks and Prediction for Tuesday August 11 2026

The Cincinnati Reds visit the Chicago White Sox at Rate Field in Chicago, Illinois, on Tuesday, August 11, 2026. First pitch is scheduled for 7:40 p.m. ET with coverage on MLB.TV. Cincinnati enters at 56-61 overall and 27-30 on the road, while Chicago is 61-56 overall and an impressive 36-22 at home. This is the first meeting of the season between the Reds and White Sox. At the time of this writing the odds were not released. Check out our free MLB picks for more predictions from Tuesday's MLB schedule.

Starting Pitchers

Nick Lodolo is scheduled to start for Cincinnati with a 3-2 record, 4.60 ERA and 1.47 WHIP through 62.2 innings. The left-hander has allowed 65 hits and 27 walks while striking out 50 and surrendering nine home runs. Chicago counters with Sean Burke, who enters at 7-6 with a strong 3.08 ERA and 1.12 WHIP across 128.2 innings. Burke has allowed 105 hits and 39 walks while recording 144 strikeouts and giving up 14 home runs. Chicago owns a substantial starting-pitching advantage based on the season numbers.

Reds Arrive in Chicago on a Three-Game Slide

Cincinnati enters Tuesday at 56-61 overall and 27-30 away from home. The Reds have lost three consecutive games after being swept by Washington, falling 5-3, 8-2 and 7-1. Cincinnati had won its previous two games against the Athletics, leaving the club at 2-3 over its last five. The offense has managed only six total runs during the current three-game losing streak.

The Reds are batting .229 with a .309 on-base percentage and .397 slugging percentage this season. Cincinnati has scored 482 runs while collecting 890 hits and hitting 154 home runs. The pitching staff owns a 4.48 ERA and 1.41 WHIP while opponents are batting .246.

Cincinnati has shown respectable power with 154 home runs, but the overall offensive profile remains a concern. The Reds trail Chicago in batting average, on-base percentage and runs scored, while their pitching numbers are also weaker. Lodolo's 4.60 ERA and 1.47 WHIP create another difficult matchup against a White Sox lineup that has produced considerably more runs this season.

White Sox Return Home With Momentum

Chicago enters this matchup at 61-56 overall and has been particularly effective at Rate Field with a 36-22 home record. The White Sox have won two straight after taking the final two games of their series against Cleveland, scoring five and six runs in those victories. Chicago is only 2-3 over its last five, but the White Sox scored 11 runs in an extra-inning loss at Boston during that stretch.

The White Sox are batting .237 with a .317 on-base percentage and .405 slugging percentage. Chicago has scored 557 runs while collecting 930 hits and hitting 152 home runs. The pitching staff has posted a 4.11 ERA and 1.31 WHIP while limiting opposing hitters to a .240 batting average.

Chicago has the more balanced statistical profile entering the series. The White Sox have scored 75 more runs than Cincinnati despite hitting two fewer home runs, while also holding advantages in ERA, WHIP and opponent batting average. Burke strengthens that pitching advantage considerably with a 3.08 ERA, 1.12 WHIP and 144 strikeouts through 128.2 innings.

Cincinnati Reds vs Chicago White Sox Picks and Prediction

Pick: Chicago White Sox Moneyline

Chicago is the preferred side behind the clear starting-pitching advantage and its strong performance at Rate Field. Burke's 3.08 ERA and 1.12 WHIP are significantly better than Lodolo's 4.60 ERA and 1.47 WHIP, while the White Sox also own the better overall pitching numbers. Cincinnati has lost three straight while scoring only six combined runs, and Chicago is 36-22 at home. With the White Sox holding advantages in recent form, starting pitching, season run production and home performance, take the Chicago White Sox on the moneyline.

Total Pick: Under 8.5

The Under 8.5 is the preferred total, largely because Burke should have an opportunity to control a struggling Cincinnati lineup. The Reds are batting only .229 and have scored three or fewer runs in each game of their current three-game losing streak. Burke owns a 3.08 ERA and 1.12 WHIP with 144 strikeouts, giving Chicago the type of starter capable of limiting Cincinnati deep into the game. Lodolo's numbers create some concern on the other side, but the Reds' offensive limitations provide enough room to work with at this number. Take the Under 8.5 if that number is available.

This game preview was completed prior to play on Monday, August 10, 2026.