Cincinnati Reds vs. Milwaukee Brewers Picks and Prediction for Saturday, September 27, 2025

By: Justin Walker Published 09/27/2025, 12:25 AM ET
Cincinnati Reds vs. Milwaukee Brewers Picks and Prediction
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In the middle game of a three-game National League Central series, the Cincinnati Reds are facing off against the Milwaukee Brewers inside American Family Field on Saturday evening in our Reds vs. Brewers prediction. This article is being written before Friday’s game. The Reds are third in the NL Central with an 81-78 record and are sending young left-hander Andrew Abbott to the mound. The Brewers are first in the NL Central with a 96-63 record and have rookie left-hander Robert Gasser getting the ball. First pitch focus β€” MLB picks for Cincinnati Reds vs. Milwaukee Brewers that cut through the noise.

Reds pushing for wild card

The Cincinnati Reds are looking to build off Thursday’s 2-1 home win against the Pittsburgh Pirates in their most recent game. They are also vying with the New York Mets to grab a wild card spot. The Reds were able to go 10-for-32 with one walk and eight strikeouts at the plate as a team. Cincinnati finished 2-for-5 with runners in scoring position while leaving seven men on base. Nick Lodolo left the game with an injury, but dominated as he pitched 6.1 shutout innings in the win.

Young left-hander Andrew Abbott is going to be taking the mound for the Cincinnati Reds in this game and has been stepping up as he is 9-7 with a 2.80 ERA and a 1.16 WHIP in 161.0 innings over 28 starts. He has been able to limit the amount of hits as he has allowed a .234 batting average against this year. Abbott faced the Brewers twice this season already as he has gone 0-1 in 13.0 innings and gave up five runs on 11 hits with one walk and 13 strikeouts.

Injury Report for Cincinnati

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  • Pitcher Nick Lodolo: Groin (Questionable)
  • Pitcher Ian Gibaut: Shoulder (OUT)
  • Pitcher Wade Miley: Flexor (OUT)
  • Pitcher Rhett Lowder: Forearm (OUT)
  • Pitcher Carson Spiers: Shoulder (OUT)
  • Left fielder Tyler Callihan: Forearm (OUT)
  • Pitcher Brandon Williamson: Elbow (OUT)
  • Pitcher Julian Aguiar: Elbow (OUT)

Brewers Waiting Until the Playoffs

The Milwaukee Brewers are looking to build off their 3-1 road win over the San Diego Padres on Wednesday. The lineup was able to go 10-for-34 with three walks and nine strikeouts on the day as Danny Jansen hit a homer and Jackson Chourio stole a base. The Brew Crew went 3-for-11 with runners in scoring position and stranded eight men on base. Chad Patrick did not factor into the decision as he pitched three shutout innings.

The Brewers are sending young southpaw Robert Gasser to pitch and he is making his second start of the season. He is 0-1 with a 6.00 ERA and a 1.00 WHIP in 3.0 innings after his first start and this is the seventh start of his career. Gasser has shown the ability to control his pitches as he has three career walks to 18 strikeouts. This will be his first career appearance against the Reds in his young career.

Injury Report for Milwaukee

  • Pitcher Brandon Woodruff: Lat (OUT)
  • Pitcher Jose Quintana: Calf (OUT)
  • Pitcher Shelby Miller: Elbow (OUT)
  • Pitcher Tylor Megill: Flexor Strain (OUT)
  • Pitcher Logan Henderson: Elbow (OUT)
  • Pitcher DL Hll: Oblique (OUT)
  • Pitcher Jordan Montgomery: Elbow (OUT)
  • Center fielder Garrett Mitchell: Oblique (OUT)
  • Pitcher Connor Thomas: Elbow (OUT)

Cincinnati Reds vs. Milwaukee Brewers Pick

Spread Pick for Reds vs. Brewers

  • Milwaukee Brewers ML (5 units)

Since the All-Star break, these offenses are on different levels as Cincinnati is 24th in the bigs with a .693 team OPS in their last 62 games, while Milwaukee is tied with the New York Mets for third place with a .783 team OPS in their 63 games. Hitting with runners in scoring position over the course of the season shows a massive difference as the Brew Crew are ninth in baseball with a .766 team OPS with runners in scoring position, while the Reds are 20th with a .726 team OPS in those chances. The Brewers have dominated this matchup as they have won seven of the last 10 games against the Reds so take the Milwaukee Brewers to secure a win at home.

Over/Under Pick for Reds vs. Brewers

  • Under (4 units)

Robert Gasser does not have much tape at the major league level and Andrew Abbott is pitching well in his last seven starts as he is 1-4 with a 4.03 ERA and a 1.32 WHIP in 38.0 innings in that span. These bullpens have been able to step up throughout the course of the season as the Reds are 15th in the majors with a 3.94 reliever ERA while the Brewers are seventh in the sport with a 3.69 bullpen ERA so far. All in all, go with the under to hit in this matchup.

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