Cincinnati Reds vs New York Yankees Picks and Prediction for Sunday June 21 2026

By: Kim Smith Published 06/21/2026, 12:00 AM ET
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The Cincinnati Reds and New York Yankees meet on Sunday, June 21, 2026, at Yankee Stadium in Bronx, New York. First pitch is scheduled for 1:35 PM ET with coverage available on MLB.TV. The Yankees enter the matchup with a 46-28 record while the Reds come in at 35-39. ESPN's matchup predictor gives New York a 56.3% chance to win compared to 43.7% for Cincinnati. At the time of this writing the odds were not released. Be sure to check out our free MLB picks at free MLB Picks.

Starting Pitchers Take Center Stage

Cincinnati is expected to send Chase Burns to the mound. Burns has been outstanding this season, posting an 8-1 record with a 2.01 ERA and 1.02 WHIP across 80.2 innings. He has allowed just 56 hits while striking out 95 batters and issuing 26 walks. New York is expected to counter with Gerrit Cole, who owns a 2-1 record with a 2.57 ERA and an even 1.00 WHIP through 28.0 innings. Cole has surrendered 20 hits, struck out 24 hitters, and walked eight.

Cincinnati Looks to Bounce Back in the Bronx

The Reds enter this contest with a 35-39 overall record and have gone 16-20 on the road this season. Cincinnati has won two of its last five games. The club recently lost to the Yankees 5-0 and also suffered a 9-1 defeat against the Mets. Their victories came against New York's National League club by scores of 5-3 and 12-0 before a recent 5-3 loss to Arizona.

Offensively, Cincinnati owns a .227 team batting average with 311 runs scored, 562 hits, and 94 home runs. The Reds have produced a .310 on-base percentage and a .392 slugging percentage. Their pitching staff has compiled a 4.66 ERA and 1.47 WHIP while allowing opponents to hit .251. Cincinnati pitchers have recorded 579 strikeouts and issued 338 walks.

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One area that stands out is the difference between the Reds' offense and pitching numbers. While the club has hit 94 home runs, the team batting average and run production rank behind New York's numbers entering this matchup. The pitching staff's 1.47 WHIP is also significantly higher than the Yankees' mark.

New York Brings Strong Numbers Into Home Matchup

The Yankees have put together an impressive 46-28 record and have been particularly effective at home with a 22-13 mark. New York has won four of its last five games. The Yankees recently defeated Cincinnati 5-0 and picked up victories over the White Sox by scores of 10-5 and 12-2. Their only loss during that stretch was a 5-1 setback against Chicago.

New York enters this game with a .246 batting average, 386 runs scored, 605 hits, and 112 home runs. The Yankees have posted a .333 on-base percentage and .442 slugging percentage. Their pitching staff has been one of the stronger units statistically, carrying a 3.30 ERA, 1.17 WHIP, and .223 opponent batting average. The club has also recorded 648 strikeouts while issuing only 226 walks.

The biggest strength for New York has been balance. The Yankees have outperformed Cincinnati in runs scored, home runs, slugging percentage, ERA, WHIP, opponent batting average, and strikeout-to-walk production. Those numbers help explain why they enter the contest as the slight favorite according to the matchup predictor.

Cincinnati Reds vs New York Yankees Picks and Prediction

Cincinnati Reds vs New York Yankees Pick

  • Pick: Yankees Moneyline

New York enters this game with advantages across several key statistical categories. The Yankees have been much stronger offensively with 386 runs and 112 home runs while also posting a superior 3.30 ERA and 1.17 WHIP. Cincinnati does have an excellent starter taking the mound, but New York's overall team profile and strong home record make the Yankees the preferred side.

Cincinnati Reds vs New York Yankees Total Pick

  • Pick: Under 8

I would lean toward the under in this matchup. Both projected starters bring ERAs below 3.00 into the contest, and Cincinnati was shut out 5-0 by New York in the most recent meeting. With two strong pitchers taking the mound and the Yankees already showing they can control the Reds' offense, the under appears to offer the better value.

Final Score Prediction: Yankees 4 – Reds 2

This Preview was completed prior to play on Saturday.

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