Cincinnati Reds vs San Diego Padres Picks and Prediction for Wednesday, September 10, 2025
In the final game of a three-game National League series, the Cincinnati Reds are taking on the San Diego Padres inside Petco Park on Wednesday evening in our Reds vs. Padres prediction. This article is being written ahead of Tuesday’s game. The Reds are third in the NL Central with a 72-72 record and are sending young left-hander Andrew Abbott to the mound. The Padres are second in the NL West with a 79-65 record and have right-hander Nick Pivetta getting the ball. Dial in your read with MLB picks for Cincinnati Reds vs San Diego Padres before first pitch.
Reds Looking to Get Into NL Wild Card Race
The Cincinnati Reds are looking to recover after their 4-3 10-inning road loss against the San Diego Padres on Monday. The lineup was able to go 7-for-37 with zero walks and 13 strikeouts on the day as TJ Friedl and Austin Hays each hit a home run, while Friedl also stole a base. Cincinnati went just 1-for-7 with runners in scoring position and stranded five men on base. Nick Lodolo did not factor into the decision as he pitched five shutout innings.
The Reds are sending young southpaw Andrew Abbott to pitch and he is doing well as in 25 starts, he is 8-6 in 143.2 innings with a 2.88 ERA and a 1.15 WHIP. He has been giving up a good amount of hits as he has a .231 batting average against so far this year. Abbott faced the Padres once this season already and he did not factor into the decision as he pitched five innings and gave up one run on seven hits with two walks and four strikeouts.
Injury Report for Cincinnati
- Pitcher Graham Ashcraft: Forearm (OUT)
- Pitcher Ian Gibaut: Shoulder (OUT)
- Pitcher Chase Burns: Elbow (OUT)
- Pitcher Wade Miley: Flexor (OUT)
- Pitcher Rhett Lowder: Forearm (OUT)
- Pitcher Carson Spiers: Shoulder (OUT)
- Left fielder Tyler Callihan: Forearm (OUT)
- Pitcher Brandon Williamson: Elbow (OUT)
- Pitcher Julian Aguiar: Elbow (OUT)
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Padres On the Heels of NL West Lead
The San Diego Padres are looking to continue playing well after Monday’s 4-3 walk-off win in 10 innings over the Cincinnati Reds in their most recent game. The Padres were able to go 6-for-33 with a pair of walks and seven strikeouts at the plate as Fernando Tatis Jr stole a base. San Diego finished 2-for-8 with runners in scoring position while leaving six men on base. Yu Darvish held his own as he pitched 5.2 innings and allowed three runs without factoring into the decision.
Right-hander Nick Pivetta is going to be taking the mound for the Padres in this game and has been pitching well as he is 13-5 with a 2.85 ERA and a 0.96 WHIP in 164.1 innings over 28 starts. He has been doing a great job in terms of limiting the amount of homers hit as he has allowed 19 this year after giving up 28 in 145.2 innings in 2024. Pivetta faced the Reds once last season as a member of the Boston Red Sox as he allowed three runs on six hits with one walk and five strikeouts in 4.1 innings in a no-decision.
Injury Report for San Diego
- Pitcher Nestor Cortes: Elbow (OUT)
- Pitcher Jason Adam: Quad (OUT)
- Shortstop Xander Bogaerts: Foot (OUT)
- Pitcher Michael King: Knee (OUT)
- Pitcher Jhony Brito: Forearm (OUT)
- Pitcher Joe Musgrove: Elbow (OUT)
Cincinnati Reds vs. San Diego Padres Pick
Spread Pick for Cincinnati Reds vs. San Diego Padres
- San Diego Padres ML (5 units)
When diving into the last seven starts, there is a gap here as Andrew Abbott is 0-5 with a 4.91 ERA and a 1.34 WHIP in 40.1 innings while Nick Pivetta is 3-2 with a 2.95 ERA and a 0.89 WHIP in 42.2 innings during that stretch. The ability to score since the All-Star break shows a gap as Cincinnati is averaging 4.45 runs in their 47 games, while San Diego is scoring 4.81 runs in their 48 games since the break. San Diego has won six of the last nine games against Cincinnati so take the San Diego Padres to secure the victory.
Over/Under Pick for Cincinnati Reds vs. San Diego Padres
- Under (4 units)
Both bullpens are doing well throughout the season as the Reds are 15th in MLB with a 4.09 bullpen ERA while the Padres are best with a 3.09 reliever ERA right now. Neither team is hitting too well with runners in scoring position this year either as Cincinnati is tied with the Baltimore Orioles and Seattle Mariners for 18th with a .735 team OPS with runners in scoring position while San Diego is 26th with a .695 team OPS in those opportunities. The under is 2-1-1 in their four games against each other this season, so go with the under here.
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