Cincinnati Reds vs Seattle Mariners Picks and Prediction for Wednesday, July 22, 2026
The Cincinnati Reds visit the Seattle Mariners at T-Mobile Park in Seattle, Washington, on Wednesday, July 22, 2026. First pitch is scheduled for 3:40 p.m. ET, with television coverage available on MLB.TV and two additional options. Cincinnati enters with a 45-54 overall record and a 23-26 road mark, while Seattle is 51-50 overall and 30-21 at home. ESPN Analytics gives the Mariners a 59.6% chance of winning, compared with 40.4% for the Reds. The supplied game information lists a temperature of 83 degrees. At the time of this writing the odds were not released. Before making any wagers on Wednesday’s matchup, be sure to check out our free MLB picks.
Starting Pitchers Take the Mound in Seattle
Brady Singer is scheduled to start for Cincinnati and enters with a 4-9 record, a 4.56 ERA, and a 1.41 WHIP. The right-hander has pitched 96.2 innings, allowing 105 hits, 31 walks, and 21 home runs while recording 82 strikeouts. Emerson Hancock gets the start for Seattle. The right-hander carries a 6-4 record with a 3.17 ERA and a 1.01 WHIP across 99.1 innings. He has surrendered 75 hits, 25 walks, and 12 home runs while collecting 94 strikeouts.
Cincinnati Looks for an Immediate Offensive Response
Cincinnati enters Wednesday with a 45-54 overall record and a 23-26 mark away from home. The Reds have gone 2-3 across their last five games after suffering an 8-0 loss to Seattle in the recent meeting. Cincinnati previously split four games from the supplied results, defeating Colorado by scores of 9-6 and 7-2 while losing to Colorado 10-3 and Chicago 8-4. The Reds have allowed at least six runs in four of their last five contests.
Cincinnati is batting .230 with 764 hits, 414 runs, and 129 home runs. The Reds have produced a .310 on-base percentage and a .399 slugging percentage. Their pitching staff owns a 4.60 ERA and a 1.44 WHIP while issuing 430 walks and recording 800 strikeouts. Opposing hitters are batting .249 against Cincinnati. The Reds have also compiled a 21-20 record in day games.
The Reds’ best statistical advantage comes from their power production. Cincinnati has hit 10 more home runs than Seattle and owns a slugging percentage that is 21 points higher. The Reds have also scored four more runs despite collecting one fewer hit. However, their pitching numbers create a significant concern. Cincinnati has the higher ERA and WHIP, has issued 179 more walks, and has recorded 71 fewer strikeouts than Seattle. The Reds will need their offense to rebound sharply after being shut out in the recent meeting.
Seattle Aims to Continue Its Winning Run at Home
Seattle enters Wednesday with a 51-50 overall record and an impressive 30-21 record at T-Mobile Park. The Mariners have won four of their last five games, including three consecutive victories. Seattle recently defeated Cincinnati 8-0 after taking two straight games from San Francisco by scores of 6-3 and 4-3 in 10 innings. The Mariners also earned an 8-2 road victory over Tampa Bay, with their only recent loss coming in a 7-0 result against San Francisco.
The Mariners are batting .230 with 765 hits, 410 runs, and 119 home runs. Seattle owns a .310 on-base percentage and a .378 slugging percentage. Its pitching staff has registered a 3.57 ERA and a 1.17 WHIP while issuing 251 walks and collecting 871 strikeouts. Opposing hitters have managed a .238 batting average against Seattle. The Mariners have gone 21-16 in day games this season.
Seattle’s clearest advantage is its pitching. The Mariners own a team ERA that is 1.03 lower than Cincinnati’s and a WHIP that is better by 0.27. Seattle has allowed a lower opposing batting average while issuing substantially fewer walks and recording more strikeouts. The starting-pitcher comparison strengthens that advantage, as Seattle’s scheduled starter has the better record, ERA, and WHIP while allowing fewer hits, walks, and home runs. The Mariners’ 30-21 home record and recent 8-0 victory provide additional reasons to favor the hosts.
Cincinnati Reds vs Seattle Mariners Picks and Prediction
Cincinnati Reds vs Seattle Mariners Pick
- Pick: Seattle Mariners Moneyline
I am backing Seattle to secure another home victory. The Mariners have won four of their last five games and recently shut out Cincinnati 8-0. Seattle holds substantial advantages in team ERA, WHIP, walks, strikeouts, and opposing batting average. The scheduled starting matchup also favors the Mariners, with their probable pitcher carrying a 3.17 ERA and a 1.01 WHIP compared with Cincinnati’s 4.56 ERA and 1.41 WHIP. ESPN Analytics gives Seattle a 59.6% probability, and the combination of stronger pitching, recent form, and a 30-21 home record makes the Mariners the preferred side.
Cincinnati Reds vs Seattle Mariners Total Pick
- Take the under if the total is set at 8.5.
I would take the under at 8.5. Seattle’s pitching staff enters with a 3.57 ERA and a 1.17 WHIP, while its scheduled starter has allowed only 75 hits across 99.1 innings. The Mariners recently held Cincinnati scoreless, and they have limited opponents to three runs or fewer in four of their last five games. Cincinnati carries considerable home-run power, but its offense must solve a favorable Seattle pitching matchup. The Mariners’ strong staff numbers give this game a reasonable path to remain below nine combined runs.
Final Score Prediction: Seattle Mariners 5 – Cincinnati Reds 2
This prediction was written before the completion of game play on Tuesday.