Cincinnati Reds vs St. Louis Cardinals Picks and Prediction for Saturday, July 25, 2026
The Cincinnati Reds visit the St. Louis Cardinals at Busch Stadium in St. Louis, Missouri, on Saturday, July 25, 2026. The opening pitch is scheduled for 7:15 p.m. ET, with television coverage available on MLB.TV. Cincinnati enters the matchup at 47-54 overall and 25-26 on the road, while St. Louis stands at 52-50 overall and 26-27 at home. ESPN Analytics gives the Reds a 45.2% chance of winning and the Cardinals a 54.8% probability. The game-time temperature is listed at 83 degrees. At the time of this writing the odds were not released. Be sure to check out our free MLB picks before Saturday’s action begins.
Starting Pitchers for Cincinnati and St. Louis
Hunter Greene is scheduled to start for Cincinnati after compiling a 2-1 record with a 6.06 ERA and 1.16 WHIP through 16.1 innings. The right-hander has allowed 14 hits and three home runs while recording 26 strikeouts against five walks. St. Louis is expected to counter with Andre Pallante, who carries a 10-6 record, 4.02 ERA and 1.26 WHIP across 105.1 innings. The Cardinals’ right-hander has surrendered 102 hits and 10 home runs while collecting 75 strikeouts against 31 walks.
Cincinnati Brings Recent Road Success into St. Louis
Cincinnati enters Saturday with a 47-54 overall record and a nearly even 25-26 mark away from home. The Reds recently earned consecutive road victories over Seattle, winning 5-3 and 4-2 after suffering an 8-0 loss in the previous meeting. They also split two road games against Colorado, earning a 9-6 victory after losing 10-3. Cincinnati has won three of its last five games, with all five contests taking place away from home.
The Reds are batting .230 with 777 hits, 423 runs and 134 home runs. Their offense owns a .309 on-base percentage and a .400 slugging percentage. Cincinnati’s pitching staff has compiled a 4.56 ERA and 1.43 WHIP while allowing opponents to bat .248. The staff has recorded 815 strikeouts and issued 437 walks. Cincinnati has posted a 25-34 record in night games.
Cincinnati’s clearest offensive strength is its power. The Reds have hit 134 home runs, giving them 24 more than the Cardinals. Their .400 slugging percentage is also 16 points higher than St. Louis’ mark. Cincinnati has scored nine runs across its current two-game winning streak while allowing only five. The concern is consistency, as the Reds have the lower batting average, on-base percentage, run total and hit total in this matchup. Their pitching staff has also issued substantially more walks than St. Louis.
St. Louis Seeks a Turnaround Behind Its Season-Long Advantages
St. Louis enters the matchup at 52-50 overall with a 26-27 record at Busch Stadium. The Cardinals most recently suffered a 10-6 home loss to Arizona after earning a 1-0 road victory over the Los Angeles Angels. That shutout represents their only win across the last five games. St. Louis also lost twice to the Angels by scores of 5-1 and 3-2 after falling 8-7 in 10 innings at Arizona.
The Cardinals are batting .241 with 823 hits, 454 runs and 110 home runs. Their lineup has generated a .317 on-base percentage and a .384 slugging percentage. St. Louis’ pitching staff owns a 4.18 ERA and 1.34 WHIP while allowing opposing hitters to bat .253. The staff has collected 770 strikeouts and issued 343 walks. The Cardinals have produced an impressive 35-26 record in night games.
St. Louis owns the better overall record and leads Cincinnati in batting average, runs, hits and on-base percentage. The Cardinals have scored 31 more runs and collected 46 more hits despite hitting 24 fewer home runs. Their pitching staff also holds advantages in team ERA, WHIP and walk total. St. Louis has issued 94 fewer walks than Cincinnati. However, the Cardinals’ recent form is a concern, as they have lost four of their last five games and surrendered 26 runs during that stretch.
Cincinnati Reds vs St. Louis Cardinals Picks and Prediction
Cincinnati Reds vs St. Louis Cardinals Pick
- Pick: St. Louis Cardinals Moneyline
St. Louis is the preferred side because it owns the stronger overall record, the higher matchup-predictor percentage and several meaningful season-long statistical advantages. The Cardinals enter at 52-50 compared with Cincinnati’s 47-54 mark. ESPN Analytics also gives St. Louis a 54.8% probability of winning, while Cincinnati receives a 45.2% chance.
Cincinnati enters with better recent form and holds the lower WHIP in the scheduled pitching matchup. However, the St. Louis starter owns a 4.02 ERA compared with the Cincinnati starter’s 6.06 mark and has worked substantially more innings. The Cardinals also lead the Reds in batting average, runs, hits and on-base percentage while carrying the better team ERA and WHIP. Cincinnati’s power and consecutive road victories make this competitive, but the broader statistical profile supports St. Louis.
Cincinnati Reds vs St. Louis Cardinals Total Pick
- Pick: Over 8.5
Take the over if the total is set at 8.5. Cincinnati’s scheduled starter carries a 6.06 ERA through 16.1 innings, while the Reds’ pitching staff owns a 4.56 ERA and 1.43 WHIP. St. Louis enters with a 4.18 team ERA, and its scheduled starter has recorded a 4.02 ERA across 105.1 innings.
Three of Cincinnati’s last five games have produced at least nine combined runs, including totals of 15, 12 and 13. Three of St. Louis’ last five contests have also reached at least nine runs, with combined totals of 16, 15 and 15. The Cardinals have allowed at least five runs in three of those games, while Cincinnati has scored nine runs across its last two victories. Those recent scoring results and the supplied pitching numbers support a combined score above 8.5.
Final Score Prediction: St. Louis Cardinals 6 – Cincinnati Reds 4
This prediction was written before the completion of game play on Friday.