Cleveland Guardians vs Boston Red Sox Picks and Prediction for Thursday, September 24, 2026

The Cleveland Guardians and Boston Red Sox meet Thursday at Fenway Park, with the opening pitch scheduled for 6:45 PM ET and the game televised on MLB.TV. Cleveland is 82-75, 41-35 away and first in the AL Central, one game ahead of Chicago. The Guardians beat Boston 3-2 on Tuesday for their sixth straight win. Boston is 84-73, 38-38 at home and third in the AL East, 12 games behind Tampa Bay. The Red Sox have lost three straight but have clinched an AL wild-card position. Here is a closer look at our free MLB picks.

Cleveland Guardians Riding a Six-Game Winning Streak

Cleveland has won five straight games listed in its recent results, including Tuesday’s 3-2 victory at Fenway Park. Chase DeLauter is batting .292 with a .367 on-base percentage, .459 slugging percentage, 15 home runs and 65 RBI. Steven Kwan has a .280 average and team-high .378 on-base percentage, while Brayan Rocchio has 13 home runs, 70 RBI and 20 stolen bases. Jose Ramirez has added 12 homers, 51 RBI and a team-high 35 stolen bases.

The Guardians rank 24th in MLB with a .239 batting average and have scored 652 runs with 152 home runs, a .316 on-base percentage and .377 slugging percentage. Cleveland’s pitching staff ranks eighth with a 3.77 ERA, 1.26 WHIP and .236 opponent average. The Guardians have recorded 1,488 strikeouts while allowing 170 home runs in 1,394.2 innings. Cleveland ranks 17th in fielding with 81 errors and a .985 fielding percentage and has gone 41-35 away from home.

Injuries: Colin Holderman (out), Rhys Hoskins (out), Shawn Armstrong (out).

Boston Red Sox Trying to End a Three-Game Slide

Boston has dropped three straight, scoring four total runs during losses to Tampa Bay and Cleveland. Willson Contreras is batting .276 with a .387 on-base percentage and .518 slugging percentage while leading Boston with 27 home runs and 81 RBI. Wilyer Abreu has 24 home runs, 74 RBI and a .453 slugging percentage. Caleb Durbin is batting .254 with 13 homers, 64 RBI and 20 stolen bases, while Masataka Yoshida owns a .274 average and .347 on-base percentage.

The Red Sox rank 12th in MLB with a .246 batting average and have scored 680 runs with 162 home runs, a .320 on-base percentage and .401 slugging percentage. Boston’s pitching staff ranks third with a 3.59 ERA, 1.24 WHIP and .242 opponent average. Red Sox pitchers have allowed 150 home runs while striking out 1,361 batters in 1,395 innings. Boston ranks 12th in fielding with 80 errors and a .986 fielding percentage and owns a 38-38 home record.

Injuries: Aroldis Chapman (questionable), Ceddanne Rafaela (out), Tanner Houck (out), Johan Oviedo (out), Curtis Mead (out).

Pitching Matchup

Cleveland Guardians - Joey Cantillo

Joey Cantillo is 10-9 with a 3.74 ERA and 1.44 WHIP in 154 innings. He has allowed 143 hits and 17 home runs with 167 strikeouts and 79 walks.

Boston Red Sox - Ranger Suarez

Ranger Suarez is 8-4 with a 3.27 ERA and 1.20 WHIP in 143.1 innings. He has allowed 127 hits and nine home runs with 135 strikeouts and 45 walks.

Cleveland Guardians vs Boston Red Sox Game Pick

• Cleveland Guardians

Cleveland is the pick with a six-game winning streak and a 41-35 road record. The Guardians have held opponents to two runs or fewer in two of their last three games, including Tuesday’s 3-2 win at Fenway Park. Boston has dropped three straight and scored only four runs across those losses. Suarez owns the lower ERA and WHIP in the starting matchup, but Cleveland’s recent results and 3.77 team ERA create enough reason to back the Guardians for another road victory.

Cleveland Guardians vs Boston Red Sox Over/Under Pick

• Under

The play is under with Cleveland and Boston carrying two of the better pitching staffs in MLB. The Red Sox rank third with a 3.59 ERA, while the Guardians rank eighth at 3.77. Cleveland has allowed 12 runs across its last five games, and Boston has scored just four runs during its three-game losing streak. Suarez has a 3.27 ERA with only nine home runs allowed in 143.1 innings, while Cantillo has 167 strikeouts across 154 innings.