Cleveland Guardians vs Chicago White Sox Picks and Prediction for Monday June 22 2026

The Cleveland Guardians and Chicago White Sox meet at Rate Field in Chicago, Illinois on Monday, June 22, 2026, with first pitch scheduled for 7:40 PM ET. The game will be televised on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers Set Up a Tight Matchup

Cleveland is expected to start Gavin Williams in this matchup. Williams enters with a 9-4 record, a 3.83 ERA, and a 1.13 WHIP across 91.2 innings. He has allowed 74 hits while striking out 103 batters, issuing 30 walks, and surrendering 15 home runs.

Chicago is expected to counter with Anthony Kay. Kay comes into the game with a 6-2 record, a 4.61 ERA, and a 1.44 WHIP over 70.1 innings. He has allowed 73 hits while recording 55 strikeouts, issuing 28 walks, and giving up 11 home runs.

Cleveland Tries to Build on a Strong Road Result

The Guardians enter this contest with a 41-36 overall record and a 22-19 mark on the road. Cleveland has won two of its last five games, recently winning over Houston and Milwaukee. The Guardians also recently lost to Houston and dropped two games against Milwaukee during that stretch. Their most recent result was an 8-1 road win, giving them a positive result to build from heading into Chicago.

Cleveland owns a .229 team batting average with 309 runs scored, 579 hits, and 74 home runs. The Guardians have posted a .314 on-base percentage and a .372 slugging percentage. On the mound, Cleveland has produced a 3.81 ERA and a 1.26 WHIP while holding opponents to a .237 batting average. The pitching staff has recorded 707 strikeouts and issued 255 walks.

The biggest strength for Cleveland is clearly on the pitching side. The Guardians have the better ERA, WHIP, opponent batting average, and strikeout total in this matchup. While their offense has not matched Chicago’s run production or power numbers, the pitching staff has helped Cleveland stay above .500 overall and on the road.

Chicago Looks to Lean on Its Home Edge

The White Sox enter Monday with a 39-36 overall record and an excellent 24-12 record at home. Chicago has won one of its last five games, recently winning over New York while also losing to Detroit twice and New York twice. Even with the recent rough stretch, the White Sox return home with one of the stronger home records among the teams playing on Monday.

Chicago has posted a .238 batting average with 349 runs scored, 592 hits, and 105 home runs. The White Sox have produced a .321 on-base percentage and a .412 slugging percentage. Their pitching staff carries a 4.41 ERA and a 1.33 WHIP while allowing opponents to hit .241. Chicago pitchers have recorded 612 strikeouts and issued 285 walks.

Chicago’s biggest advantage is power. The White Sox have hit 105 home runs compared to Cleveland’s 74, and they have also scored 40 more runs. That offensive edge is important because the pitching numbers favor Cleveland, meaning Chicago may need its lineup to create enough scoring to protect its home-field advantage.

Cleveland Guardians vs Chicago White Sox Picks and Prediction

Cleveland Guardians vs Chicago White Sox Pick

• Pick: Cleveland Guardians Moneyline

Cleveland gets the slight lean despite Chicago’s narrow edge in ESPN’s matchup predictor. The Guardians have the better overall record, winning road record, and stronger pitching numbers. Cleveland also has the more favorable starting pitching profile based on ERA, WHIP, strikeouts, and hits allowed. Chicago has been excellent at home, but the White Sox have dropped four of their last five games, while Cleveland enters off a strong road victory.

Cleveland Guardians vs Chicago White Sox Total Pick

• Pick: Take the under if the total is set at 8.5

I would lean toward the under if the total is set at 8.5. Cleveland’s pitching staff has a 3.81 ERA and a 1.26 WHIP, and its expected starter brings a 1.13 WHIP into this matchup. The Guardians have also scored 309 runs with a .229 batting average, which keeps their offensive projection modest. Chicago has more power, but Cleveland’s pitching numbers make the under the better side for me at that number.

Final Score Prediction: Cleveland Guardians 4 – Chicago White Sox 3

This prediction was written before the completion of game play on Sunday.