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Cleveland Guardians vs New York Yankees Picks and Prediction for Thursday June 4 2026

By: Kim Smith Published 06/04/2026, 05:25 AM ET
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The Cleveland Guardians and New York Yankees meet on Thursday, June 4, 2026, at Yankee Stadium in Bronx, New York. First pitch is scheduled for 1:35 PM ET, and the game will be broadcast on MLB.TV. At the time of this writing the odds were not released. This matchup features two winning clubs battling in a series that has already produced plenty of offense, with both teams looking to gain an important victory heading into the next portion of their schedules. Be sure to check out our free MLB picks for additional daily analysis and selections.

Starting Pitchers

Cleveland is expected to send Slade Cecconi to the mound, while New York is scheduled to start Carlos Rodon. Cecconi enters this matchup with a 3-5 record, a 5.25 ERA, and a 1.49 WHIP over 61.2 innings. He has allowed 72 hits while striking out 50 batters, walking 20, and giving up nine home runs. Rodon comes into the contest with a 1-2 record, a 3.32 ERA, and a 1.32 WHIP across 19.0 innings. He has allowed 12 hits, struck out 20 batters, walked 13, and surrendered one home run.

Cleveland Attempts to Keep Momentum Rolling

The Guardians enter Thursday's game with a 35-27 overall record and an 18-13 record on the road. Cleveland recently won over New York 9-4, recently lost to Boston by scores of 9-4 and 9-1, and recently won over Boston 4-3 and Washington 3-2. The Guardians have won three of their last five games and arrive in the Bronx after posting a convincing victory in the most recent meeting between these teams.

Cleveland has produced a .234 batting average while scoring 258 runs on 474 hits. The Guardians have hit 57 home runs and carry a .321 on-base percentage with a .375 slugging percentage. Their pitching staff has been effective throughout the season, posting a 3.75 ERA and a 1.28 WHIP while holding opponents to a .239 batting average. Cleveland pitchers have also recorded 578 strikeouts and issued 209 walks.

One of Cleveland's greatest strengths is its ability to miss bats. The Guardians lead this matchup in strikeouts with 578, which is higher than New York's total. They also own a solid pitching profile overall, with a team ERA under 4.00 and a respectable opponent batting average, helping them remain competitive even when the offense has been inconsistent.

Yankees Look to Bounce Back at Home

The Yankees come into this contest with a 36-24 overall record and a strong 17-10 home record. New York recently lost to Cleveland 9-4 but had previously recently won over Oakland by scores of 13-8 and 8-2, recently lost to Oakland 6-4, and recently won over Kansas City 7-0. Despite the recent defeat, the Yankees have won four of their last five games and remain one of the strongest teams in this matchup based on season-long results.

New York has posted a .243 team batting average while scoring 309 runs on 482 hits. The Yankees have hit 87 home runs, carry a .333 on-base percentage, and own a .434 slugging percentage. Their pitching staff has been equally impressive with a 3.29 ERA, a 1.18 WHIP, and a .225 opponent batting average. New York pitchers have recorded 516 strikeouts while issuing 185 walks.

The Yankees' biggest strength is their balance. They hold the advantage in runs scored, home runs, on-base percentage, slugging percentage, ERA, WHIP, and opponent batting average. Those numbers help explain why New York owns the better overall record and remains one of the more productive clubs on both sides of the ball.

Cleveland Guardians vs New York Yankees Picks and Prediction

Cleveland Guardians vs New York Yankees Pick

  • Pick: New York Yankees Moneyline

New York is the preferred side despite dropping the most recent game in the series. The Yankees have the better overall record, the stronger home record, and advantages across nearly every major offensive category. They have scored 309 runs compared to Cleveland's 258 and have hit 87 home runs compared to 57 for the Guardians. New York also owns the lower team ERA and WHIP. When combined with the pitching matchup and ESPN's matchup predictor favoring the Yankees at 68.0%, New York stands out as the stronger choice.

Cleveland Guardians vs New York Yankees Total Pick

  • Pick: Over 8.5

I would take the over if the total is set at 8.5. The most recent meeting finished 9-4, producing 13 total runs. New York has scored 309 runs this season, while Cleveland has scored 258. The Yankees have also shown significant power with 87 home runs, and Cleveland's starting pitcher enters with a 5.25 ERA. Based on the offensive production and the most recent result between these teams, I lean toward the over.

Final Score Prediction: New York Yankees 6 – Cleveland Guardians 4

This prediction was written before the completion of game play on Wednesday.