Colorado Rockies vs Chicago White Sox Picks and Prediction for Friday September 25 2026

The Colorado Rockies visit the Chicago White Sox at Rate Field in Chicago, Illinois, on Friday, September 25, 2026. First pitch is scheduled for 7:40 PM ET with coverage on MLB.TV. Colorado enters at 57-101 overall and 25-53 on the road, while Chicago is 81-77 overall and 46-32 at home. The Rockies have lost three straight games and sit fifth in the NL West, while the White Sox are only one game behind Cleveland for first place in the AL Central with four games remaining. Friday opens the first and only regular-season series between Colorado and Chicago this year. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

Colorado is scheduled to start Jose Quintana, who enters at 2-3 with a 5.40 ERA and 1.51 WHIP through 45 innings. He has allowed 50 hits and eight home runs while recording 22 strikeouts against 18 walks. Chicago had not announced its starting pitcher at the time this preview was completed, leaving some uncertainty surrounding the pitching matchup. Quintana's numbers create concerns for Colorado regardless of the opponent. He has allowed more hits than innings pitched, owns a WHIP above 1.50 and has recorded only 22 strikeouts through 45 innings. Chicago's undecided starter makes the early innings more difficult to project, but Colorado does not enter with an obvious starting-pitching advantage.

Colorado's Pitching Remains the Major Concern

Colorado enters this series at 57-101 overall and has struggled considerably away from home with a 25-53 road record. The Rockies have lost four of their last five games, including three straight, and recently dropped consecutive games to Arizona by scores of 7-2 and 5-3. Their lone victory during the five-game stretch was a 5-3 win over Seattle. Colorado has scored 15 runs and allowed 22 over those five contests, continuing a season in which preventing runs has been the team's biggest problem.

The Rockies are batting .253 with 732 runs, 1,361 hits and 172 home runs. They own a .322 on-base percentage and .415 slugging percentage, giving them better batting-average and slugging numbers than Chicago. Those offensive numbers have not been enough to overcome a pitching staff carrying a 5.55 ERA and 1.52 WHIP. Colorado has issued 521 walks against 1,085 strikeouts while opponents are batting an extremely high .288. The Rockies are also just 40-65 in night games.

Colorado's offense gives it a chance to compete, but the difference between the clubs becomes significant on the mound. The Rockies have allowed opponents to hit nearly .290 for the season and enter with a team ERA 1.40 runs higher than Chicago's. That becomes particularly concerning on the road, where Colorado has won fewer than one-third of its games. With the scheduled starter also carrying a 5.40 ERA, the Rockies could need another productive offensive performance simply to remain within striking distance.

Chicago Returns Home With the Division Still in Play

Chicago enters Friday at 81-77 overall and remains very much involved in the AL Central race, sitting only one game behind Cleveland. The White Sox have also performed particularly well at Rate Field, posting a 46-32 home record. Chicago has won three of its last five games despite dropping a 5-4 decision at Kansas City in its most recent completed contest. The White Sox recently scored 14 runs against Kansas City and eight against Detroit, giving them 37 runs over their last five games.

The White Sox are batting .235 with 751 runs, 1,244 hits and 203 home runs. Their .320 on-base percentage and .403 slugging percentage are relatively modest, but Chicago has produced 19 more runs than Colorado despite recording 117 fewer hits. The White Sox also hold a sizable power advantage with 31 more home runs. Chicago's pitching staff owns a 4.15 ERA and 1.32 WHIP with 1,299 strikeouts against 563 walks while limiting opponents to a .243 batting average. The White Sox are 49-46 in night games.

Chicago's combination of power and superior run prevention is the central matchup advantage. The White Sox do not hit for the same average as Colorado, but they have been more productive at converting their offense into runs and possess considerably more home-run power. More importantly, their pitching staff has been dramatically better. Chicago's .243 opponent batting average is 45 points lower than Colorado's .288 mark. Add in the White Sox's 46-32 home record and the urgency of a one-game divisional deficit, and Chicago enters with several substantial statistical advantages.

Colorado Rockies vs Chicago White Sox Picks and Prediction

Pick: Chicago White Sox Moneyline

Chicago is the side despite the uncertainty surrounding its starting pitcher. The White Sox are 24 games better than Colorado in the standings and have gone 46-32 at Rate Field, while the Rockies are just 25-53 on the road. Colorado's 5.55 ERA, 1.52 WHIP and .288 opponent batting average are difficult numbers to overcome against a Chicago offense that has scored 37 runs over its last five games. The White Sox also own the stronger season-long pitching profile and a 203-172 advantage in home runs. Colorado's scheduled starter enters with a 5.40 ERA and 1.51 WHIP, giving Chicago an opportunity to establish an offensive advantage even before its own unannounced starter becomes part of the equation. With the White Sox also only one game out of first place in the AL Central, Chicago is the moneyline choice.

Pick: Over 8.5 or Lower

The pitching numbers make the over the more attractive total angle if the number opens at 8.5 or lower. Colorado owns a 5.55 team ERA and has allowed opponents to hit .288, while its scheduled starter carries a 5.40 ERA and has surrendered 50 hits in only 45 innings. Chicago has scored 37 runs over its last five games, including outputs of 14 and eight runs, and has hit 203 home runs this season. Colorado can contribute as well, as the Rockies own a .253 batting average, .322 on-base percentage and .415 slugging percentage. Chicago's unannounced starter adds uncertainty, which further supports avoiding an aggressive under position. At 8.5 or lower, there is enough offensive potential on both sides—particularly against Colorado's pitching—to back the over.

Final Picks: Chicago White Sox Moneyline and Over 8.5 or Lower

This preview was completed on Thursday, September 24, 2026. Starting pitchers, betting lines and other game information are subject to change before the game begins.