Colorado Rockies vs Chicago White Sox Picks and Prediction for Saturday September 26 2026

The Colorado Rockies visit the Chicago White Sox at Rate Field in Chicago, Illinois, on Saturday, September 26, 2026. First pitch is scheduled for 7:10 PM ET with coverage on MLB.TV. Colorado enters the weekend at 57-102 overall and 25-53 on the road, while Chicago is 82-77 overall and 46-32 at home. The Rockies sit fifth in the NL West and enter the weekend on a four-game losing streak. Chicago is second in the AL Central and trails Cleveland by only one game, putting the White Sox directly in the division race entering the final weekend. Friday's series opener had not been completed at the time this preview was prepared and is excluded from the analysis. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

Colorado is scheduled to start Jose Quintana, who enters at 2-3 with a 5.40 ERA and 1.51 WHIP through 45 innings. He has allowed 50 hits and eight home runs while recording 22 strikeouts against 18 walks. Chicago counters with Davis Martin, who is 9-7 with a 3.84 ERA and 1.29 WHIP across 145.1 innings. He has surrendered 143 hits and 14 home runs while striking out 121 and walking 45. The White Sox own a clear starting-pitching advantage. Martin has a substantially lower ERA and WHIP over more than three times as many innings, while Quintana has allowed more hits than innings pitched and owns a relatively modest strikeout rate.

Rockies Continue to Struggle With Run Prevention

Colorado enters Saturday at 57-102 overall and has lost four consecutive completed games. The Rockies were swept in their three-game series against Arizona, falling by scores of 7-2, 5-3 and 12-8. They previously lost 2-1 against Seattle after recording a 5-3 victory in the preceding game. Colorado has scored 19 runs across its last five completed games but has surrendered 29.

The Rockies are batting .254 with 740 runs, 1,378 hits and 175 home runs. They own a .323 on-base percentage and .417 slugging percentage, giving them surprisingly solid offensive numbers despite their overall record. Colorado's problems have overwhelmingly come on the pitching side. The Rockies own a 5.59 team ERA and 1.53 WHIP with 1,092 strikeouts against 526 walks while allowing opponents to hit .289.

That run prevention becomes particularly concerning Saturday because Colorado is also sending out a starter with a 5.40 ERA and 1.51 WHIP. The Rockies have the higher team batting average, OBP and slugging percentage in this matchup, so the offense is capable of contributing. The problem is asking that offense to consistently compensate for a pitching staff allowing opponents to hit nearly .290. Colorado's 25-53 road record further illustrates how difficult that formula has been away from home.

White Sox Have Everything to Play For

Chicago enters Saturday at 82-77 overall and just one game behind Cleveland in the AL Central. The White Sox have won four of their last five completed games and are coming off a convincing 9-1 victory over Kansas City. Chicago also defeated the Royals 14-11 during that series after sweeping its final two completed games against Detroit by scores of 8-1 and 3-1. The White Sox have scored 38 runs across their last five games while allowing 19.

Chicago is batting .236 with 760 runs, 1,256 hits and 204 home runs. The White Sox own a .321 on-base percentage and .404 slugging percentage. Their batting average trails Colorado considerably, but Chicago has scored 20 more runs and hit 29 more home runs. The difference becomes much larger on the mound, where the White Sox own a 4.13 ERA and 1.32 WHIP with 1,309 strikeouts against 564 walks while holding opponents to a .243 batting average.

Chicago's power is particularly important in this matchup. The White Sox have surpassed 200 home runs, and they draw a Colorado staff carrying a 5.59 ERA and 1.53 WHIP. Chicago has also scored at least eight runs in three of its last four victories. Combined with the substantial starting-pitching advantage and a 46-32 home record, the White Sox have multiple paths to controlling Saturday's game.

Colorado Rockies vs Chicago White Sox Picks and Prediction

Pick: Chicago White Sox Moneyline

Chicago is the clear side selection Saturday. The White Sox are 46-32 at home while Colorado is only 25-53 on the road, and Chicago has won four of its last five completed games compared with four straight losses for the Rockies. The starting-pitching matchup also heavily favors the White Sox, with Chicago's starter carrying a 3.84 ERA and 1.29 WHIP compared with Colorado's 5.40 ERA and 1.51 WHIP. The largest gap is found in the overall pitching numbers: Chicago owns a 4.13 team ERA compared with Colorado's 5.59 and has held opponents to a .243 average compared with .289 for the Rockies. With Chicago also fighting for the AL Central lead, the White Sox are the preferred moneyline play.

Pick: Over 8.5 or Lower

The over is the preferred total if the market opens at 8.5 or lower. Colorado has a 5.59 ERA and 1.53 WHIP, and Saturday's scheduled starter enters with a 5.40 ERA and 1.51 WHIP. Chicago has scored 38 runs across its last five completed games and has hit 204 home runs this season, creating the potential for the White Sox to contribute heavily to the total themselves. Colorado also has a better offense than its record might suggest, batting .254 with a .417 slugging percentage and 740 runs. Chicago's starting advantage could limit the Rockies early, but the combination of Colorado's poor run prevention and both teams' offensive production makes Over 8.5 or lower the better position.

Final Picks: Chicago White Sox Moneyline and Over 8.5 or Lower

This preview was completed on Friday, September 25, 2026. Starting pitchers, betting lines and other game information are subject to change before the game begins.