Colorado Rockies vs San Diego Padres Picks and Prediction for Saturday, September 13, 2025
Our Rockies vs. Padres prediction sees the Colorado Rockies (40-107) getting ready to take on the San Diego Padres (80-67) in National League West action at Petco Park on Saturday night in the third game of a four-game series. This article is being written ahead of Friday’s game. Right-hander Antonio Senzatela gets the start for the Rockies while righty Dylan Cease pitches for the Padres. First pitch focus — MLB picks for Colorado Rockies vs San Diego Padres that cut through the noise.
Rockies Looking to Play Spoiler
The Colorado Rockies are looking to recover from their 2-0 road loss on Friday against the San Diego Padres to open their series. The lineup was held to go 4-for-31 with zero walks and 14 strikeouts as Mickey Moniak stole a base. The team was 0-for-5 with runners in scoring position and stranded all four men on base. McCade Brown recorded the loss despite pitching well, as he allowed two runs in 4.1 innings.
Right-hander Antonio Senzatela will be getting the start for the Colorado Rockies and is struggling as he is 4-15 with a 6.71 ERA and a 1.85 WHIP in 123.1 innings (27 games, 23 starts) so far. He has done a poor job in terms of keeping the ball in the park, as he has given up a career-high 22 home runs. Senzatela faced the Rockies twice already this season (one start) and has gone 0-1 in 8.1 innings and allowed eight runs (four earned) on 13 hits with four walks and five strikeouts.
Injury Report for Colorado
- Pitcher Chase Dollander: Knee (Questionable)
- Pitcher Luis Peralta: Hip (OUT)
- Shortstop Warming Bernabel: Concussion (OUT)
- Pitcher Dugan Darnell: Hip (OUT)
- Second baseman Thairo Estrada: Hamstring (OUT)
- Pitcher Seth Halvorsen: Elbow (OUT)
- Pitcher Zach Agnos: Hand (OUT)
- Designated hitter Kris Bryant: Lumbar (OUT)
- Pitcher Jeff Criswell: Elbow (OUT)
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Padres Looking to Capture NL West
The San Diego Padres are coming off a 2-0 home win on Thursday against the San Diego Padres last time out. The team stepped up offensively as they were able to go 6-for-30 with two walks and nine strikeouts as Jackson Merrill homered while Luis Arraez stole a base. San Diego was 1-for-5 with runners in scoring position and left six men on base. Randy Vasquez recorded the win as he pitched six innings.
The Padres are going to be sending right-hander Dylan Cease to the mound and he is currently 7-11 with a 4.71 ERA and a 1.34 WHIP in 151.0 innings. He has limited the amount of hits against him as he has a .239 batting average against. Cease faced the Rockies in his last start as he secured the win by going five innings and gave up one run on four hits with two walks and five strikeouts.
Injury Report for San Diego
- Pitcher Nestor Cortes: Elbow (OUT)
- Pitcher Jason Adam: Quad (OUT)
- Shortstop Xander Bogaerts: Foot (OUT)
- Pitcher Jhony Brito: Forearm (OUT)
- Pitcher Joe Musgrove: Elbow (OUT)
Colorado Rockies vs. San Diego Padres Pick
Spread Pick for Colorado Rockies vs. San Diego Padres
- San Diego Padres ML (5 units)
These starting pitchers over the previous seven outings show a gap as Antonio Senzatela is 0-2 with a 7.92 ERA and a 1.92 WHIP in 25.0 innings (four starts) while Dylan Cease is 4-1 with a 4.41 ERA and a 1.35 WHIP in 32.2 innings (seven starts). When looking at the team OPS in road/home games, there’s a significant difference as the Rockies are last in baseball with a .590 road OPS while the Padres are 21st with a .700 home OPS right now. The Padres are winners of eight of the previous 10 games against the Rockies, so take the San Diego Padres to be victorious once again.
Over/Under Pick for Colorado Rockies vs. San Diego Padres
- Under (4 units)
In September, these pitchers are stepping up as Antonio Senzatela is 0-0 with a 1.08 ERA and a .265 batting average against in 8.1 innings (two relief appearances) while Dylan Cease is 1-0 with a 3.00 ERA and a 1.44 WHIP in 9.0 innings (two starts). Both teams have been brutal with runners in scoring position as Colorado is 29th with a .673 team OPS with runners in scoring position, while San Diego is 26th with a .686 team OPS in those chances. All in all, go with the under to hit here.
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