Colorado Rockies vs. San Francisco Giants Picks and Prediction, Sunday, September 28, 2025

By: Cole Shelton Published 09/27/2025, 10:48 PM ET
Rockies vs Giants prediction.

An NL West matchup goes down on Sunday, September 28 at 3:05 p.m. ET as the Colorado Rockies take on the San Francisco Giants, so continue reading for our Rockies vs. Giants prediction. This is written before Saturday's game has ended.

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Rockies Last in MLB

Colorado enters play on Saturday with a record of 43-117 and has the worst record in baseball. The Rockies are hitting .238, which ranks 23rd, while in the month of September, they are hitting .228. On the road, Colorado is hitting .204. Against Webb, Karros is 1-for-1, Ritter is 1-for-2, Tovar hits .389 in 18 ABs with a homer, Moniak hits .286 in 14 at-bats, and Doyle hits .125 in 16 at-bats.

The Rockies are set to start McCade Brown, who's 0-4 with a 7.54 ERA in 6 starts this season. In his last outing, he went 5 innings, allowing 1 run against the Mariners. He has never faced the Giants in his career. Colorado has a team ERA of 6.00, which ranks 30th.

Giants Starting Webb

San Francisco enters play with a record of 79-81 and won't be making the playoffs this season. The Giants are set to start right-hander Logan Webb, who's 14-11 with a 3.30 ERA in 33 starts this season. Last time out, he went six innings, allowing 3 runs against the Cardinals. He's 10-3 with a 3.12 ERA in his career against Colorado. San Francisco has a team ERA of 3.87, which ranks 12th.

The Giants are hitting .235, which ranks 25th, while at home, they are hitting .239. In the month of September, San Francisco is hitting .239. No batter has faced Brown in the majors.

Rockies vs. Giants Pick

Money Line pick for Rockies vs. Giants

  • Giants ML (5 units)

Colorado and San Francisco don't have anything to play for here, but this is still a good spot for the Giants to get the win. Webb has pitched well this season as he will dominate the Rockies' offense, which has struggled all season. Brown, meanwhile, has struggled, as has the Rockies' pitching staff, as San Francisco will cruise to a lopsided win here and end the year on a high note.

Over/Under Pick for Rockies vs. Giants

  • Under (4 units)

With Webb on the mound, the under is a good spot here, as Colorado won't be able to score many runs, as this seems like a 5-1 win here for the Giants. San Francisco is 75-75-10 in hitting the under, while Colorado is 84-72-4 in hitting the under. Brown, meanwhile, also pitched well in his last outing, which should give him confidence to help the under cash.

Take the under.

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