Detroit Tigers vs Boston Red Sox Prediction and Picks - September 28, 2025

By: Dean Whitaker Published 09/28/2025, 05:00 AM ET
Trevor Story looks to lead the Red Sox over the Tigers
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Major League Baseball action on Sunday afternoon, we have a Detroit Tigers vs Boston Red Sox Prediction ready to go. The Tigers are battling for a playoff spot with the Cleveland Guardians, while the Red Sox have already secured a spot in the postseason. Detroit has taken the first two games of this series. Read on to see our Tigers vs Red Sox prediction.

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The Tigers Have Clinched A Playoff Spot

Detroit secured a 2-1 victory over Boston on Saturday, powered by Keider Montero’s strong outing and timely hitting. Montero tossed 4.1 innings, giving up one run on four hits while striking out seven, before the bullpen carried the load. Jahmai Jones provided the difference at the plate with a two-run single in the fifth inning, and Will Vest recorded his 23rd save to close it out.

The win not only gave the Tigers another series lead but also officially clinched them a postseason berth, guaranteeing at least a Wild Card spot. It marks a major step forward for Detroit, who leaned on pitching and timely offense to navigate a competitive September. Riley Greene and Colt Keith continue to headline the lineup, while Spencer Torkelson has chipped in with situational RBIs despite a down year in power numbers. The bullpen has been lights out, posting some of its best work in recent weeks.

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For Sunday’s finale, Detroit hands the ball to Casey Mize, who enters at 3-6 with a 4.12 ERA. Mize has shown stretches of promise when commanding his fastball and secondary pitches, though inconsistency has limited his outings at times. With the Tigers having secured a postseason berth, the focus will be on keeping the pitching staff sharp and healthy while still playing to finish the season strong. Greene, Keith, and Torkelson will look to provide early run support for Mize.

Boston Is Trying To Avoid The Sweep

Boston dropped Saturday’s game 2-1 in Detroit, with the offense unable to solve Tigers pitching after striking early. Their lone run came in the second inning when Nick Sogard lined an RBI single to bring home Ceddanne Rafaela. Despite putting runners on base throughout the afternoon, the Red Sox couldn’t cash in during the later innings and finished 1-for-7 with men in scoring position. Connelly Early pitched well enough to keep them in the game, allowing two runs over 5.2 innings while striking out seven, but he was tagged with the loss after Jahmai Jones’ two-run single in the fifth inning proved to be the difference.

The setback moved Boston to 88-73, one night after they clinched a postseason berth with a dramatic walk-off win. The Red Sox remain firmly in a Wild Card spot with only a few games left, though their focus now is on sharpening execution before October. The lineup has shown flashes in September, with Ceddanne Rafaela making strides as an all-around contributor, Jarren Duran bringing speed and on-base ability at the top, and Masataka Yoshida providing steady contact in the middle. Players like Sogard and Romy Gonzalez have chipped in situational hitting, but the lack of consistency with runners on base has been a recurring issue.

Boston has yet to name a starter for Sunday’s finale, and with the bullpen logging significant work in the series, the club may look to piece the game together with multiple arms if no spot starter is announced. The bullpen has been a relative strength, keeping games within reach even when the offense struggles. Offensively, Boston needs to string together more quality at-bats and take advantage of opportunities when they arise. With their playoff spot secure but seeding still up for grabs, the Red Sox will be motivated to close out the season strong and regain momentum heading into October.

Detroit Tigers vs Boston Red Sox Pick

Tigers vs Red Sox Moneyline Pick

  • Boston (4 Units)

The Red Sox enter Sunday with urgency as they look to avoid being swept in Detroit, and their position in the Wild Card race gives them plenty of motivation. Even in Saturday’s 2-1 loss, Boston created opportunities with seven hits, and players like Ceddanne Rafaela and Jarren Duran continued to set the table with speed and contact at the top of the order. Masataka Yoshida remains a steady presence in the middle, and the supporting cast has shown the ability to contribute in key spots. If Boston can string together quality at-bats and convert with runners in scoring position, they have the offensive depth to break through in the finale.

On the pitching side, Boston has yet to name a starter, but the bullpen has been reliable in keeping games close throughout September. With postseason play already clinched, the Red Sox can approach this game with a mix of flexibility and determination, using their arms strategically to hold Detroit’s lineup in check. The bats should carry the load, and with seeding still on the line, Boston has the incentive and the talent to bounce back, avoid the sweep, and head into October with positive momentum.

Tigers vs Red Sox Over/Under Pick

  • Under (5 Units)

With Detroit and Boston both leaning on pitching and struggling to capitalize with runners in scoring position, the Under looks like the right side here. Saturday’s 2-1 result highlighted the theme of this series — strong bullpen work and missed offensive chances. Even without an official line, both lineups have been inconsistent, and Detroit has been winning with low-scoring formulas all September. Expect another tight, grind-it-out contest where runs are limited and the final tally stays in the five-to-six run range.

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