Detroit Tigers vs. Seattle Mariners Picks and Prediction, Game 5, Friday October 10, 2025
After four hard-fought games, the second ALDS matchup is set for a winner-take-all Game Five that we'll take a look at with our Detroit Tigers vs. Seattle Mariners prediction.
The Detroit Tigers (2-2) have already won two must-win games this post-season, and with their big-time ace taking the mound in this one, they'll be confidence in their chances of advancing to the ALCS.
Standing in their way are the Seattle Mariners (2-2), a team that have been picked as the heavy favorite in this series, and with a team lineup and great pitching, they won't want to lose their World Series hopes in this game. Read on to see our Detroit Tigers vs. Seattle Mariners prediction.
Expected pitching matchup: LHP Tarik Skubal vs. RHP George Kirby.
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Can the Tigers ace get it done again?
The Detroit Tigers have given their all across seven post-season games to date, and with a 3-2 record in five road games in that time, they'll be full of confidence behind their ace in this matchup: In those five road games, the Tigers have averaged just three runs per game, and with their opponents scoring exactly three per game in that time, they'll have a hard fight on their hands in this winner-take-all matchup.
In this one, Detroit turns to its superstar ace, Tarik Skubal, who has a dominant 1.84 ERA over two starts this postseason, and with 23 strikeouts in 14.2 innings of work in that time, he's going to give them every opportunity to win in this one. Last time out for the Tigers was a big win over these Mariners, with four RBI to Javier Baez leading the way as Casey Mize tossed 3.0 innings of scoreless baseball as they won a must-win matchup 9-3.
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Can the Mariners punch their ticket to the ALCS?
The Seattle Mariners came into this series as major favorites, and while they've looked good in two victories, they've also taken some losses, and now, they need to put up their best performance of the 2025 season to date. In their two wins in this series, the Mariners have posted 11 total runs, but in their losses, they've managed just five, and if they are to advance to the ALCS, it will all come on the back of how their lineup performs.
Taking the mound for Seattle here will be star right-hander George Kirby, who tossed 5.0 innings of one-run ball in Game One of this series, and now, they'll hope he can back it up with another big performance in this matchup. Last time out for the Mariners was a tough loss to these Tigers, with Bryce Miller's 4.1 innings of two-run ball not enough to get the job done as the team managed just three runs on eight hits, falling 9-3 in the process.
Detroit Tigers vs. Seattle Mariners pick
Moneyline pick for Tigers vs. Mariners
- Seattle +118 (4 units)
Through four games, this series has been absolutely thrilling, and with both teams splitting their home/road games 1-1, this could be another hard-fought battle for two very talented, balanced squads.
While Tarik Skubal gives the Tigers the advantage, the Mariners have been one of the league's best home teams this season with a 51-30 home record, and with an MVP candidate leading the way, expect them to step up and pick up a decisive Game Five victory.
Over/under pick for Tigers vs. Mariners
- Under 7 (4 units)
Unsurprisingly, the under is the easy pick here with the two big aces taking the mound, as the previous matchup of both these starters saw them each allow just two runs over a combined 13.0 innings of work.
In the two games played in Seattle, there was a total of five runs scored, and with so much weighing on the starters in this one, expect it to be a very low-scoring affair.
Keep it simple, take the under.
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