Free MLB Picks Today – MLB Best Bets For Tuesday, September 23 2025

By: Dean Whitaker Published 09/23/2025, 12:15 PM ET
Logan Webb looks to lead the Giants over the Cardinals
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We’re catching fire on the diamond, riding a 7-2 run in our last MLB Best Bets. Now we turn to Tuesday’s slate, which is stacked with opportunity. Three games have been targeted, each backed by sharp pitching analysis, offensive trends, and matchup insight. The mission is simple—keep the streak alive and keep cashing tickets.

Below, let's take a look at some of my favorite MLB picks for today, in best bets form.

Let's Start Tonight's Best Bets With A Pitcher's Duel

Under 7.5 in tonight’s Cardinals–Giants matchup is a sharp lean, anchored by a strong pitching edge and two underwhelming offenses. Logan Webb takes the mound for San Francisco with a 3.27 ERA, 21 quality starts, and a proven ability to work deep into games—he’s allowed just one earned run over his last 14 innings. Andre Pallante counters for St. Louis, and while his 5.29 ERA raises concerns, he’s backed by a bullpen that’s converted 86 holds and allowed just 33.2% of inherited runners to score, keeping damage in check.

Offensively, both teams rank bottom-10 in slugging and batting average, with San Francisco hitting just .234 and St. Louis slugging .378 despite playing in hitter-friendly parks. Oracle Park’s spacious dimensions and cooler night air further suppress scoring, and with playoff hopes fading, expect a tight, low-scoring duel—think 4–2 or 3–3 heading into the late innings, making the Under 7.5 the sharper side.

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Best Bet#1

  • St Louis/San Francisco Under 7.5

A Sluggfest Out West Highlights Best Bet #2

Over 10 in tonight’s matchup between Houston and the A's is a sharp play, fueled by power bats and shaky pitching on both sides. Cristian Javier takes the mound with a 4.45 ERA, and while he’s shown flashes of dominance, he’s allowed seven home runs over his last five starts and faces a lineup that ranks sixth in MLB in home runs (214) and fourth in slugging (.432).

Jeffrey Springs counters with a 4.17 ERA, and though he’s held opponents to a .238 average, he’s been tagged for six earned runs in two of his last four outings, including a rough stretch against playoff-caliber lineups. Both teams have combined for over 1,300 hits and 1,300 strikeouts, suggesting plenty of contact and run-producing opportunities. With warm conditions at Sutter Health Park and bullpens that have blown 32 combined save chances, this game profiles as a 6–5 or 7–4 finish, making the Over 10 the sharper side.

Best Bet #2

  • Houston/ Athletics Over 10

The Rangers Round Out Today's Best Bets

Rangers over the Twins is the sharper side in tonight’s AL matchup, with Patrick Corbin drawing the start against Zebby Matthews in a favorable home spot. Corbin has logged 21 outings of five or more innings this season and enters with a 4.33 ERA, facing a Minnesota lineup that ranks just 24th in runs scored and 28th in turning balls in play into outs.

Matthews, meanwhile, owns a 6.26 ERA and a 1.61 WHIP, allowing nearly 12 hits per nine innings, and has struggled to keep runners off base in high-leverage spots. Texas has won 63.4% of games when favored by -138 or more, and their offense—led by Wyatt Langford and Adolis García—has enough pop to exploit a Twins bullpen that’s blown 24 of 51 save chances. With playoff urgency and a strong home record, the Rangers are well-positioned to control tempo and cash the moneyline at Globe Life Field.

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Best Bet#3

  • Texas -132

Recapping today's MLB Best Bets

  • St Louis/San Francisco Under 7.5
  • Houston/Athletics Over 10
  • Texas -132
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