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Free MLB Picks Today – MLB Best Bets For Wednesday, September 24 2025

By: Dean Whitaker Published 09/24/2025, 01:03 PM ET
Jesus Luzardo looks to lead the Phillies over the Marlins

Wednesday’s MLB board sets up with plenty of betting value. We’ve zeroed in on three key matchups, each broken down through pitching matchups, lineup performance, and recent trends. The focus is clear—capitalize on today’s opportunities and turn sharp analysis into winning results.

Below, let's take a look at some of my favorite MLB picks for today, in best bets form. These just missed out on being on my premium card, unless otherwise noted.

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The Cardinals enter tonight’s matchup with more to play for in terms of momentum, and their pitching matchup gives them a tangible edge. Sonny Gray brings a strikeout-heavy arsenal and has shown he can navigate tough lineups on the road. The Giants’ offense has been streaky and vulnerable to well-located breaking stuff and high-velocity fastballs, and Gray’s ability to keep hitters off balance could force them into weak contact. Meanwhile, the Cardinals’ lineup—while not explosive—has a few hitters who can punch in runs when needed and tends to avoid prolonged cold spells, giving them a chance to push across enough to stay in contention.

On the other side, the Giants’ bullpen has been in a rough patch, and when late-inning control matters most, they may struggle to hold leads or come-from-behind deficits. San Francisco will lean on home-field energy and the hope of their offense waking up, but against Gray and with a shaky relief corps, that may not be enough. I expect a tight, tense affair where St. Louis executes better in the later innings and leverages situational hitting to stay in control.

Best Bet#1

  • St Louis -102

Best Bet #2 - A Pitcher's Duel In Philly

This game projects to stay quiet through most of the innings. On paper, the starting arms have enough upside — Ryan Weathers (Marlins) and Jesús Luzardo (Phillies) — to keep hitters off balance, especially early when they’re fresh and mixing stuff. MLB.com+1 Neither rotation is overloaded with firepower late into this contest, which should limit the big innings from either side. Meanwhile, both bullpens have had shaky moments lately, but there’s incentive to minimize damage and navigate carefully, which tends to favor the defense and pitching in low-scoring affairs.

Offensively, both lineups have the capacity for beats and bursts, but consistency has been lacking, especially against pitchers who locate well and generate weak contact. The Phillies’ recent success has leaned heavily on starter strength rather than bullpen dominance, and the Marlins simply don’t carry enough offensive firepower to override two or three strong frames from Luzardo. Add in the fact that both teams will want to avoid mistakes, and the under 8 stands out as a fitting outcome for a pitcher’s duel more than a slugfest.

Best Bet #2

  • Miami/Philadelphia Under 8

The Orioles Round Out Today's Best Bets

Baltimore enters tonight’s game with an edge in both pitching and consistency. Their starter has shown the ability to quiet opposing lineups and eat innings, giving the bullpen a manageable task. Meanwhile, the Rays’ lineup has struggled to maintain pressure against deep pitching staffs—it often comes in fits and starts rather than sustained offensive barrages. Baltimore’s hitters may not light it up in every inning, but they do enough—stringing together baserunners, taking advantage of mistakes, and manufacturing runs in tight spots.

Defensively and in situational play, Baltimore has the upper hand. Their bullpen is sharper late in games, and they’ve been better at avoiding the big inning—a weakness for Tampa Bay in recent outings. The Rays will attempt to counter with speed and contact, but it’s hard to see them consistently doing damage against a polished staff. Expect Baltimore to control tempo, stay patient at the plate, and close this one out in the late frames.

Best Bet#3

  • Baltimore -113

Recapping today's MLB Best Bets

  • St Louis -102
  • Miami/Philadelphia Under 8
  • Baltimore -113
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