Giants vs. Dodgers Prediction and Picks - September 21, 2025
Giants vs. Dodgers Prediction and Picks - September 21, 2025
The Giants are facing off against the Dodgers in game four of their series at Dodger Stadium in Los Angeles, California; keep reading for our Giants versus Dodgers prediction. San Francisco is fourth in the NL West with a record of 76-78. Los Angeles is at the top of the NL West with a record of 87-67. The Dodgers are 8-3 against the Giants this season. The first pitch is scheduled for 4:10 p.m. EDT. Need some winners this baseball season? Check out our Free MLB Picks.
This article was written before the Giants versus Dodgers game on 9/20.
Giants’ Offense Continues To Struggle
The Giants picked up another loss on Friday versus the Dodgers with a final score of 6-3. This is the sixth loss in the last seven games for the Giants as they continue to struggle to generate wins. San Francisco, with their loss on Friday, may have sealed the deal on their chances at making a wild card spot as it currently has a winning percentage of .494 to the Mets’ .519, who hold the bottom wild card spot in the National League. Between them are the Reds and Diamondbacks, who are both also striving for the bottom wild card.
The Giants have relied on being walked and stealing to generate runs as they sit seventh overall in walks and fourth in stolen bases. I say this because the Giants are 17th in runs due to a batting average of .235 (26th) and a slugging percentage of .385 (26th). This has not improved lately as the Giants have averaged only 2.83 runs per game in their last six, with a batting average of .153 and a slugging percentage of .232.
The Giants have not confirmed a starting pitcher at the time this article was written.
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Dodgers Clinch Playoff Berth
The Dodgers are coming off an important win on Friday against the Giants with a final score of 6-3. This is the third win in a row for the Dodgers and their fifth win in their last seven games. Los Angeles, with their win on Friday, clinched their playoff berth but still needs a few more wins to clinch the top of the NL West.
The Dodgers this season have dominated on offense, and this has not changed in recent games. At the plate this season, the Dodgers are second overall in runs and rank sixth in batting average at .254. The key to their offense lies in their slugging as they sit second in slugging percentage at .440 and, as a result, also rank second in home runs. In their last 10 games, the Dodgers are averaging 6.4 runs per game with a batting average of .288 and a slugging percentage of .513.
Right-handed pitcher Emmet Sheehan will be starting for the Dodgers on Sunday.
Emmet Sheehan:
- has a record of 6-3 with an ERA of 3.17 and 76 strikeouts in 13 appearances this season.
- has a 1-0 record with an ERA of 1.20 and 15 strikeouts in 3 appearances versus the Giants in his career.
Giants vs. Dodgers Prediction and Picks
Run Line Pick for Giants vs. Dodgers
- Dodgers -1.5 ( 4 units )
The Dodgers have a record of 6-2 against the run line as favorites in their last eight games at home. The Giants have a record of 5-9 against the run line as underdogs in their last 14 games against the NL West. Los Angeles may be more motivated now that they have clinched their playoff berth and the top of their division. There are only a few more wins the Dodgers need to clinch the top of the NL West, and a series sweep against the Dodgers would definitely help their odds. I do not believe they are going to hold anything back in this series finale and given how well Emmet Sheehan has performed against the Giants in the past, it should be one-sided.
Over/Under Pick for Giants vs. Dodgers
- Under ( 4 units)
The Giants have an over/under record of 1-4-2 in their last seven games on the road. The Dodgers have an over/under record of 3-7-4 in their last 14 games at home. The Giants already struggle on the season, generating runs and lately have struggled even more. Now they have to face a reliable pitcher in Emmet Sheehan, and I do not see them generating many runs at all in this game. The Dodgers have been handicapped going up against this Giants’ pitching and while they are still generating runs, it is not as explosive as they can be. We should expect a low-scoring one-sided game in this one.
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