Houston Astros vs. Athletics Picks and Prediction for Tuesday, September 23, 2025
Our Astros vs. Athletics prediction sees the Houston Astros (84-72) getting ready to take on the Athletics (73-83) in American League West action at Sutter Health Park on Tuesday night in the first game of a three-game series. Both teams were off on Monday, so they are rested up entering this series. Right-hander Cristian Javier gets the start for the Astros while southpaw Jeffrey Springs pitches for the Athletics. First pitch focus — MLB picks for Houston Astros vs. Athletics that cut through the noise.
Astros Need to Correct Course to Keep Season Alive
The Houston Astros are looking to bounce back after their 7-3 home loss on Sunday against the Seattle Mariners to fall out of the playoff picture. The lineup was able to go 7-for-35 with one walk and six strikeouts as Zach Cole and Isaac Paredes each hit a home run while Jose Altuve stole a base. The Astros were only 1-for-7 with runners in scoring position and stranded seven men on base. Jason Alexander was brutal in the game as he allowed seven runs while only being able to record four outs.
Right-hander Cristian Javier is going to toe the slab for the Houston Astros and has only made seven starts this season. He is 2-3 with a 4.45 ERA and a 1.24 WHIP in 32.1 innings of work. He has been struggling with his command a bit as he has allowed 14 walks to 30 strikeouts entering this start. Javier faced the Athletics once last season in a win as he threw six shutout innings as he gave up two hits with one walk and eight strikeouts.
Injury Report for Houston
- Shortstop Jeremy Pena: Oblique (Questionable)
- Left fielder Yordan Alvarez: Ankle (OUT)
- Pitcher Kaleb Ort: Elbow (OUT)
- Pitcher Lance McCullers Jr: Hand (OUT)
- Pitcher Luis Garcia: Elbow (OUT)
- Pitcher Spencer Arrighetti: Elbow (OUT)
- Pitcher John Rooney: Concussion/Nasal (OUT)
- Pitcher Bennett Sousa: Elbow (OUT)
- Pitcher Brandon Walter: Elbow (OUT)
- Pitcher Josh Hader: Shoulder (OUT)
- Second baseman Brendan Rodgers: Oblique (OUT)
- Right fielder Zach Dezenzo: Hand (OUT)
- Right fielder Pedro Leon: Knee (OUT)
- Pitcher Ronel Blanco: Elbow (OUT)
- Pitcher Hayden Wesneski: Elbow (OUT)
Sign Up for StatSalt News Alerts, Get Free Picks and Discounts
Subscribe Now
Athletics Trying to Bounce Back?
The Athletics are coming off a brutal 11-0 road loss on Sunday against the Pittsburgh Pirates in their most recent outing. The team was able to go 8-for-35 with zero walks and nine strikeouts as a whole, with just one extra-base hit. The Athletics were 0-for-8 with runners in scoring position and left all eight men on base. Mitch Spencer struggled in the losing effort as he gave up seven runs (six earned) over 3.1 innings.
The Athletics are going to be sending left-hander Jeffrey Springs to the mound and he is currently 10-11 with a 4.17 ERA and a 1.22 WHIP in 166.0 innings. He has struggled to keep the ball in the park as he has given up 28 home runs up to this point. Springs faced the Astros once already this season in a win as he pitched six innings and gave up two runs on four hits with one hit by pitch, one walk, and five strikeouts.
Injury Report for Athletics
- Second baseman Zack Gelof: Shoulder (OUT)
- Pitcher Sean Newcomb: Elbow (OUT)
- Pitcher Ben Bowden: Lat (OUT)
- Pitcher Joey Estes: Back (OUT)
- Pitcher Jacob Lopez: Flexor (OUT)
- Pitcher Jack Perkins: Shoulder (OUT)
- Catcher Austin Wynns: Abdomen (OUT)
- Pitcher Jose Leclerc: Shoulder (OUT)
- Center fielder Denzel Clarke: Abductor (OUT)
- Pitcher Grant Holman: Shoulder (OUT)
- Pitcher Gunnar Hoglund: Hip (OUT)
- Pitcher Luis Medina: Elbow (OUT)
Houston Astros vs. Athletics Pick
Spread Pick for Astros vs. Athletics
- Athletics ML (4 units)
These teams are on two completely different levels, hitting since the All-Star break as the Astros are down at 26th place with a .684 team OPS, while the Athletics are fifth in MLB with a .777 team OPS since the break. The pitching staffs also show a similar gap in that same timespan as Houston is 18th with a 4.29 team ERA in their 60 games, while the Athletics are ninth with a 3.90 team ERA in their 58 games. The Athletics won each of the previous five games against the Astros, so go with the Athletics to secure a victory.
Over/Under Pick for Astros vs. Athletics
- Over (5 units)
The road/home splits show they are struggling as Cristian Javier is 0-1 with a 7.88 ERA and a 1.75 WHIP in 8.0 innings (two road starts) while Jeffrey Springs is 5-5 with a 5.00 ERA and a .254 opposing batting average in 77.1 innings (14 games, 13 home starts) heading into this game. Both teams are hitting well over the course of the year in terms of their batting average of balls in play as Houston is 11th with a .296 batting average of balls in play as a team, while the Athletics are seventh with a .298 team BABIP. The over 5-4-1 in their last 10 games against one another so take the over here.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $200
