Houston Astros vs Atlanta Braves Picks and Prediction for Saturday, September 13, 2025
In the second game of a three-game interleague series, the Houston Astros are taking on the Atlanta Braves inside Truist Park on Saturday evening in our Astros vs. Braves prediction. The Astros opened the series with a commanding 11-3 win on Friday. The Astros are first in the AL West with a 79-68 record and are sending right-hander Hunter Brown to the mound. The Braves are fourth in the NL East with a 65-81 record and have young righty Bryce Elder getting the ball. Cover the diamond — MLB picks for Houston Astros vs Atlanta Braves in a fast read.
Astros Looking to Hold Onto AL West Lead
The Houston Astros are coming off a commanding 11-3 road win over the Atlanta Braves on Friday. The lineup was able to go 13-for-39 with three walks and nine strikeouts on the day as Zach Cole and Jose Altuve each hit a home run. Houston went an outstanding 6-for-9 with runners in scoring position and stranded five men on base. Jayden Murray pitched as an opener and did well as he threw three innings and did not allow a run.
The Astros are sending righty Hunter Brown to pitch and he is dominating as in 28 starts, he is 11-7 in 167.2 innings with a 2.25 ERA and a 1.01 WHIP. He has been an overwhelming hitter as he has a .198 batting average against so far this year. Brown faced the Braves once last season in a loss as he allowed two runs on five hits with three walks and three strikeouts in six innings of work.
Injury Report for Houston
- Pitcher Lance McCullers Jr: Hand (OUT)
- Pitcher Luis Garcia: Elbow (OUT)
- Pitcher Kaleb Ort: Elbow (OUT)
- Pitcher Spencer Arrighetti: Elbow (OUT)
- Pitcher John Rooney: Concussion/Nasal (OUT)
- Pitcher Bennett Sousa: Elbow (OUT)
- Pitcher Brandon Walter: Elbow (OUT)
- Pitcher Josh Hader: Shoulder (OUT)
- Third baseman Isaac Paredes: Hamstring (OUT)
- Second baseman Brendan Rodgers: Oblique (OUT)
- Right fielderZach Dezenzo: Hand (OUT)
- Right fielder Pedro Leon: Knee (OUT)
- Pitcher Ronel Blanco: Elbow (OUT)
- Pitcher Hayden Wesneski: Elbow (OUT)
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Braves Looking to Play Spoiler
The Atlanta Braves are looking to bounce back after Friday’s 11-3 home loss to the Houston Astros in their most recent game. The Braves were able to go 5-for-32 with a pair of walks and five strikeouts at the plate as Ronald Acuna Jr and Eli White hit home runs. Atlanta did not have an at-bat with runners in scoring position while also leaving four men on base. Hurston Waldrep recorded his first loss of the season as he allowed eight runs in 4.2 innings.
Young right-hander Bryce Elder is going to be taking the mound for the Braves in this game and has been struggling as he is 7-9 with a 5.35 ERA and a 1.41 WHIP in 138.0 innings over 25 starts. He has been doing an okay job in terms of limiting the amount of homers hit, as he has allowed 20 this year after giving up eight in 49.2 innings in 2024. Elder faced the Astros once in 2023 as he did not factor in the decision by pitching six innings and allowed an unearned run on five hits with one hit by pitch, one walk, and six strikeouts.
Injury Report for Atlanta
- Pitcher Daysbel Hernandez: Shoulder (OUT)
- Catcher Sean Murphy: Hip (OUT)
- Third baseman Austin Riley: Abdominal (OUT)
- Pitcher Aaron Bummer: Shoulder (OUT)
- Pitcher Grant Holmes: Elbow (OUT)
- Pitcher Spencer Schwellenbach: Elbow (OUT)
- Pitcher AJ Smith-Shawver: Calf/Elbow (OUT)
- Pitcher Reynaldo Lopez: Shoulder (OUT)
- Pitcher Joe Jimenez: Knee (OUT)
Houston Astros vs. Atlanta Braves Pick
Spread Pick for Houston Astros vs. Atlanta Braves
- Houston Astros -145 (5 units)
The road/home splits for these starting pitchers show a significant gap as Hunter Brown is 6-2 with a 2.26 ERA and a .211 batting average in 87.2 innings (15 road starts) while Bryce Elder is 3-4 with a 6.44 ERA and a 1.72 WHIP in 65.2 innings (13 home starts) so far. These bullpens are performing at different levels this year as well with Houston being 10th with a 3.74 reliever ERA, while Atlanta is down at 21st place with a 4.31 bullpen ERA. All in all, go with the Houston Astros to win here.
Over/Under Pick for Houston Astros vs. Atlanta Braves
- Under (4 units)
These pitchers in their last seven starts show they can step up as Hunter Brown is 2-2 with a 1.44 ERA and a 1.05 WHIP in 43.2 innings, while Bryce Elder is 3-1 with a 3.89 ERA and a 1.07 WHIP in 44.0 innings in that stretch. Both teams struggle with runners in scoring position this season as the Astros are tied with the St. Louis Cardinals for 22nd with a .712 team OPS with runners in scoring position, while the Braves are 17th with a .739 team OPS in those chances. Go with the under in this game as the better bet here.
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