Houston Astros vs. Chicago White Sox Picks and Prediction for July 24, 2026

By: Kim Smith Published 07/24/2026, 12:20 AM ET

The Houston Astros visit the Chicago White Sox at Rate Field in Chicago, Illinois, on July 24, 2026. The game is scheduled for 7:40 p.m. and will be televised on MLB.TV. Houston enters the matchup with a 50-54 overall record and a 24-27 record on the road, while Chicago is 54-47 overall and 31-17 at home. ESPN Analytics gives the Astros a 40.1% chance of winning and the White Sox a 59.9% chance. The listed game-time temperature is 77 degrees. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers

Spencer Arrighetti is scheduled to start for Houston against Chicago right-hander Davis Martin. Arrighetti is 7-5 with a 4.34 ERA and a 1.31 WHIP through 87 innings. He has allowed 66 hits and 12 home runs while recording 87 strikeouts and issuing 48 walks. Martin enters with a 9-5 record, a 3.31 ERA, and a 1.27 WHIP across 106 innings. He has surrendered 102 hits and six home runs while collecting 97 strikeouts and allowing 33 walks. Martin owns the lower ERA and WHIP, has earned two more wins, and has issued 15 fewer walks. Arrighetti has allowed fewer hits, although he has also worked 19 fewer innings.

Houston Carries a Three-Game Winning Streak Into Chicago

Houston is 50-54 overall and 24-27 away from home entering Friday’s matchup. The Astros have won three of their last five games, including three consecutive victories over Miami by scores of 5-2, 5-3, and 8-5. Those wins followed losses of 5-2 and 4-2 against Baltimore, with the latter defeat lasting 11 innings. Houston scored 18 runs during its three-game winning streak after producing only four combined runs in the preceding two losses.

The Astros have recorded a .242 batting average, a .315 on-base percentage, and a .413 slugging percentage. They have scored 473 runs on 843 hits while hitting 142 home runs. Houston’s pitching staff enters with a 4.71 ERA and a 1.39 WHIP. The staff has issued 453 walks, collected 915 strikeouts, and limited opposing hitters to a .240 batting average. The Astros are also 31-35 in night games.

Houston’s most apparent strength is its power production. Its 142 home runs are 11 more than Chicago’s 131, while its .413 slugging percentage is slightly better than the White Sox’s .409 mark. The primary concern is run prevention, as Houston’s 4.71 ERA and 1.39 WHIP are both higher than Chicago’s corresponding figures. The Astros have also issued 78 more walks, creating an area in which the visiting team will need a sharper performance.

Chicago Leans on Its Home Record and Pitching Advantage

Chicago brings a 54-47 overall record and an impressive 31-17 home record into the series opener. The White Sox have won three of their last five games, recently earning victories over Texas by scores of 4-2 and 10-3 while also defeating Toronto 3-0. Their two losses during that stretch were a 10-0 defeat against Texas and a narrow 1-0 setback against Toronto. Chicago held its opponent to two runs or fewer in three of the five games.

The White Sox have a .240 batting average, a .318 on-base percentage, and a .409 slugging percentage. They have accumulated 809 hits, scored 483 runs, and hit 131 home runs. Chicago’s pitching staff owns a 4.08 ERA and a 1.31 WHIP while holding opposing batters to a .238 average. The staff has recorded 853 strikeouts and allowed 375 walks. Chicago has also posted a 33-23 record in night games.

Chicago’s clearest advantage is its combination of home success and stronger run prevention. The White Sox have won 31 of their 48 games at Rate Field, while their team ERA is 0.63 lower than Houston’s. Chicago also has the lower WHIP and opposing batting average, and it has issued considerably fewer walks. Although the White Sox trail the Astros in hits, home runs, batting average, and slugging percentage, they have scored 10 more runs and hold the slightly better on-base percentage.

Houston Astros vs. Chicago White Sox Picks and Prediction

Houston Astros vs. Chicago White Sox Pick

  • Pick: Chicago White Sox Moneyline

Chicago is my side selection because the White Sox hold the stronger overall record, the better home split, and the advantage in the supplied matchup projection. Chicago is 31-17 at home, while Houston is 24-27 on the road. The White Sox also have the lower team ERA and WHIP, and their scheduled starter enters with better figures in both categories. Houston’s three-game winning streak and power production make this competitive, but Chicago’s pitching numbers and 59.9% matchup probability give the home team the stronger overall profile.

Houston Astros vs. Chicago White Sox Total Pick

  • Pick: Under 8.5

Take the under if the total is set at 8.5. I favor the under because Chicago has held three of its last five opponents to two runs or fewer, while Houston was limited to two runs in each of its two losses during its recent five-game stretch. Chicago owns a 4.08 team ERA and a 1.31 WHIP, and its scheduled starter carries a 3.31 ERA. Houston’s 142 home runs and recent offensive production create some risk, but the White Sox’s pitching advantage supports a lower-scoring projection.

Final Score Prediction: Chicago White Sox 5 – Houston Astros 3

This prediction was written before the completion of game play on Thursday.

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