Houston Astros vs. Los Angeles Angels Picks and Predictions - Saturday, September 27th

By: Anthony Leute Published 09/27/2025, 12:30 AM ET
Astros versus Angels Prediction

Astros versus Angels Picks and Predictions - Saturday, September 27th

The Astros are facing off against the Angels in game two of their series at Angel Stadium in Anaheim, California; keep reading for our Astros versus Angels prediction. Houston is second in the AL West with a record of 85-74. Los Angeles is last in the AL West with a record of 71-88. The Astros have a record of 6-4 against the Angels this season. The first pitch is scheduled for 9:39 p.m. EDT. Need some winners this baseball season? Check out our Free MLB Picks.

This article was written before the Astros versus Angels game on 9/26.

Astros Close To Playoffs

The Astros are coming off a much-needed win on Thursday versus the Athletics with a final score of 11-5. Despite this win, the Astros would still lose their series against the Athletics 2-1. This win would break up a five-game losing streak the Astros had amassed and every game matters when you're in the playoff hunt. Houston is one spot away from a wild-card spot as they trail the Tigers, who hold that bottom spot with a .541 winning percentage, while they themselves have a winning percentage of .535. Every win will matter as they head into their final series of the season.

Houston has relied on their pitching this season as their offense has not been able to generate consistent runs. However, recently, the pitching has been declining and because of this, the Astros risk losing their chance at the playoffs. On the season, Houston is 14th in ERA at 3.89 but ranks 21st in home runs allowed. In their last six games, the Astros have an ERA of 5.54 and have allowed eleven home runs across those six games. This may be due to them facing teams that have impressive slugging, which would take advantage of the weakness in the Astrosโ€™ pitching.

No pitcher has been confirmed at the time of writing this article for Houston.

Angelsโ€™ Pitching Causing More Losses

The Angels picked up another loss on Thursday versus the Royals with a final score of 9-4. This loss would lose the series against the Royals 1-2. Los Angeles is far removed from any chances of the postseason as they remain at the bottom of their division.

Los Angeles this season has had issues at both the plate and mound this season but their mound performances has been the key to why they remain at the bottom of their division. The Angels this season rank 28th in ERA at 4.89, 28th in home runs, and 30th in walks. Lately ,we have not seen much improvement from their pitching core and bullpen as they look toward the end of their season. The Angels have an ERA of 6.54 in their last ten games and have allowed an average of four walks per game.

Right-handed pitcher Caden Dana will be taking the mound for the Angels on Saturday.

Caden Dana:

  • has a 0-3 record with an ERA of 6.39 and 28 strikeouts in 6 appearances this season.
  • has allowed 5 runs on 5 hits with 2 walks and 3 strikeouts in 3.1 innings against the Astros in his career.

Astros vs. Angels Picks and Predictions

Money Line Pick for Astros vs. Angels

  • Astros Money Line (4 units)ย 

The Astros are 8-2 in their last ten games versus the Angels on the road. The Angels are 5-10 in their last 15 games at home. Houston is going to be heavily motivated in this series to grab a win as they are desperate for every win remaining this season for a chance at the postseason. They are only one win behind the Tigers for the final wild card spot in the American League and will attempt to make a final push for that spot in this series. The Astros are facing off against an Angelsโ€™ team that has struggled at the mound on the season and especially as of late. While the Astros have not been reliable at the plate this season, going up against a struggling mound should be just what they need to grab a needed win.

Over/Under Pick for Astros versus Angels

  • Over ( 4 units)ย 

The Angels have an over/under record of 6-3 in their last nine games at home. The Astros have an over/under record of 7-5 in their last 12 games. While I have faith that the Astros will grab the win in this matchup, the Astros are still struggling against teams that have a decent slugging percentage. The Angels are 15th this season in slugging percentage at .398 and are fourth in home runs. This may be an issue for the Astros as they continue to struggle at stopping opposing teams that can generate reliable home runs. This will likely turn into a high-scoring affair between a team that can excel at the plate and a team desperate for wins.

>

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright ยฉ 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.