Houston Astros vs Toronto Blue Jays Picks and Prediction for Monday June 22 2026

By: Kim Smith Published 06/22/2026, 12:45 AM ET
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The Houston Astros and Toronto Blue Jays meet at Rogers Centre in Toronto, Ontario on Monday, June 22, 2026, with first pitch scheduled for 7:07 PM ET. The game will be televised on ESPN Unlmtd and MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers Headline the Series Opener

Houston is expected to start Hunter Brown in this matchup. Brown has made a strong impression in limited work this season, posting a 1-0 record with a 1.10 ERA and a 1.04 WHIP across 16.1 innings. He has allowed just 8 hits while recording 24 strikeouts, issuing 9 walks, and not allowing a home run.

Toronto is expected to counter with Shane Bieber. No statistics were provided for Bieber entering this game, but he is listed as the probable starter for the Blue Jays.

Houston Seeks to Build on Recent Success

The Astros enter Monday's contest with a 36-42 overall record and a 17-21 record on the road. Houston has won three of its last five games, recently defeating Cleveland once and Detroit twice. The Astros also suffered losses to Cleveland and Detroit during that stretch, but they have shown flashes of solid play over the past week.

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Houston owns a .243 team batting average with 354 runs scored, 638 hits, and 102 home runs. The Astros have posted a .318 on-base percentage and a .413 slugging percentage. On the mound, Houston carries a 4.89 ERA and a 1.41 WHIP while allowing opponents to hit .243. The pitching staff has recorded 671 strikeouts and issued 344 walks.

The biggest strength for Houston is its power production. The Astros have hit 102 home runs, significantly more than Toronto's total. Houston has also scored more runs and produced a higher slugging percentage, giving the club an offensive advantage entering this matchup.

Toronto Returns Home After a Strong Road Trip

The Blue Jays come into Monday's game with a 38-39 overall record and a 21-18 mark at home. Toronto has won four of its last five games, recently defeating Chicago once and Boston three times. The Blue Jays' only loss during that stretch came in a road game against Chicago, but they have otherwise been playing some of their best baseball of the season.

Toronto has compiled a .249 batting average with 316 runs scored, 643 hits, and 77 home runs. The Blue Jays own a .311 on-base percentage and a .391 slugging percentage. Their pitching staff has produced a 4.13 ERA and a 1.31 WHIP while holding opponents to a .242 batting average. Toronto pitchers have recorded 677 strikeouts and issued 266 walks.

Toronto's greatest advantage lies on the pitching side. The Blue Jays have the lower ERA, lower WHIP, fewer walks allowed, and lower opponent batting average. They have also recorded more strikeouts than Houston despite facing the same stage of the season.

Houston Astros vs Toronto Blue Jays Picks and Prediction

Houston Astros vs Toronto Blue Jays Pick

  • Pick: Houston Astros Moneyline

Houston enters this matchup with the advantage in ESPN's matchup predictor and holds significant offensive advantages in runs scored, home runs, and slugging percentage. The Astros have also won three of their last five games and are expected to send a starter to the mound who has posted excellent numbers this season. While Toronto has played well recently, Houston's offensive profile and matchup predictor edge make the Astros the selection.

Houston Astros vs Toronto Blue Jays Total Pick

  • Pick: Take the over if the total is set at 8.5

I would lean toward the over if the total is set at 8.5. Houston has scored 354 runs and hit 102 home runs this season, while Toronto has collected 643 hits and enters the game after winning four of its last five contests. Both offenses have shown the ability to generate scoring opportunities, making the over attractive at that number.

Final Score Prediction: Houston Astros 5 – Toronto Blue Jays 4

This prediction was written before the completion of game play on Sunday.

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