Los Angeles Angels vs. Colorado Rockies Picks and Prediction for Saturday, September 20, 2025
The Los Angeles Angels (69-84, 82-65-6 O/U) will be taking on the Colorado Rockies (41-112, 68-81-4 O/U) on Saturday night in the middle game of a three-game interleague series for our Angels vs. Rockies prediction. This article is being written ahead of Friday’s opening game of the series. Veteran right-hander Kyle Hendricks (7-10, 5.01 ERA) is going to be pitching in this game for the Angels while the Rockies are sending righty German Marquez (3-14, 6.73 ERA) to the hill. From splits to bullpens, MLB predictions for the Los Angeles Angels vs. Colorado Rockies highlight the edge.
Angels in the Outfield
The Los Angeles Angels are looking to end the season strong as they are fifth in the AL West with a 69-84 record up to this point. The offense is not doing too well as they are 22nd in baseball with a .226/.300/.398 team slash line while averaging 4.22 runs per game.
The Los Angeles Angels are coming off a 5-2 road loss on Thursday against the Milwaukee Brewers and Luis Rengifo hit his ninth homer of the season. Yusei Kikuchi did not factor into the decision as he pitched 5.2 innings and allowed two runs.
Center fielder Jo Adell (36 HR, .791 OPS) has been a significant power threat as the season rolls on and should be able to get to the 100 RBI total. Veteran right-hander Kyle Hendricks (7-10, 5.01 ERA) will be taking the mound and is coming off a loss against the Seattle Mariners, where he threw 3.1 innings and gave up nine runs on 10 hits with two walks and six strikeouts.
Injury Report for Los Angeles
- Third baseman Yoan Moncada: Ankle (Questionable)
- Pitcher Jose Soriano: Ribs (OUT)
- Shortstop Zach Neto: Hand (OUT)
- Catcher Travis d’Arnaud: Head (OUT)
- Pitcher Andrew Chafin: Triceps (OUT)
- Pitcher Reid Detmers: Elbow (OUT)
- Right fielder Jorge Soler: Back (OUT)
- Pitcher Ryan Zeferjahn: Knee (OUT)
- Pitcher Victor Mederos: Shoulder (OUT)
- Pitcher Carson Fulmer: Elbow (OUT)
- Right fielder Gustavo Campero: Ankle (OUT)
- Pitcher Tyler Anderson: Oblique (OUT)
- First baseman Nolan Schanuel: Wrist (OUT)
- Pitcher Hunter Strickland: Shoulder (OUT)
- Pitcher Ben Joyce: Shoulder (OUT)
- Third baseman Anthony Rendon: Hip (OUT)
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Cold as the Rockies
The Colorado Rockies are looking towards the end of the season as they are last in the NL West with a 41-112 record up to this point. The Rockies are hitting at a brutal level as they are 27th in the bigs with a .686 team OPS while averaging 3.75 runs per game.
The Colorado Rockies are coming off Thursday’s 9-7 home loss against the Miami Marlins, and the team was 3-for-12 with runners in scoring position. Tanner Gordon struggled in a losing effort as he gave up four runs (three earned) in six innings.
Catcher Hunter Goodman (30 HR, .850 OPS) has been one of the best catchers in baseball and can continue to improve as the season comes to a close. Right-hander German Marquez (3-14, 6.73 ERA) is going to be on the mound and is coming off a loss against the San Diego Padres, where he allowed seven runs on 10 hits with two walks and zero strikeouts in 2.1 innings.
Injury Report for Colorado
- Pitcher Chase Dollander: Knee (OUT)
- Pitcher Luis Peralta: Hip (OUT)
- Shortstop Warmer Bernabel: Concussion (OUT)
- Pitcher Dugan Darnell: Hip (OUT)
- Second baseman Thairo Estrada: Hamstring (OUT)
- Pitcher Seth Halvorsen: Elbow (OUT)
- Pitcher Zach Agnos: Hand (OUT)
- Designated hitter Kris Bryant: Lumbar (OUT)
- Pitcher Jeff Criswell: Elbow (OUT)
Los Angeles Angels vs. Colorado Rockies Pick
Spread Pick for Angels vs. Rockies
- Los Angeles Angels -132 (5 units)
There is a bit of a difference when diving into the road/home splits on the mound as Kyle Hendricks is 2-5 with a 5.78 ERA and a 1.33 WHIP in 71.2 innings (14 road starts) while German Marquez is 1-8 with a 6.45 ERA and a .321 batting average against in 51.2 innings (10 home starts) right now. The ability to hit with runners in scoring position shows a significant gap, as Los Angeles is tied with the Athletics for 11th with a .762 team OPS with runners in scoring position, while Colorado is down at 27th with a .683 team OPS in those chances. All in all, go with the Los Angeles Angels to win here.
Over/Under Pick for Angels vs. Rockies
- Over (4 units)
When diving into the previous seven starts for these pitchers, they are struggling. Kyle Hendricks is 1-2 with a 6.25 ERA and a 1.61 WHIP in 36.0 innings during that stretch, while German Marquez is 0-5 with a 9.66 ERA and a 2.21 WHIP in 31.2 innings in that span. Both bullpens are struggling throughout the season as the Angels are 28th with a 4.88 reliever ERA, while the Rockies are 29th with a 5.33 bullpen ERA up to this point. The over has hit in six of the previous nine games, so take the over once again.
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