Los Angeles Angels vs. Colorado Rockies Picks and Prediction, Sunday, September 21, 2025
An interleague matchup goes down on Sunday, September 21, as the Los Angeles Angels close out their series against the Colorado Rockies at 3:10 p.m. ET, so continue reading for our Angels vs. Rockies prediction. This is written before Saturday's game has ended.
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Angels End Road Trip
Los Angeles enters play on Saturday with a record of 69-85 and plays their final road game of the 2025 MLB season on Sunday. The Angels are hitting .227, which ranks 29th. On the road, they are hitting .224. Meanwhile, in the month of September, Los Angeles is hitting .211. Against Freeland, O'Hoppe is 2-for-3 with a homer, Taylor hits .233 in 30 ABs with two homers, Schanuel is 1-for-3, Trout hits .167 in six at-bats with a homer, Ward hits .125 in 8 ABs, and Adell is 0-for-5.
The Angels are expected to start left-hander Sam Aldegheri, who's 0-0 with a 10.38 ERA, as it figures to be a bullpen game for Los Angeles. Aldegheri went two innings, allowing five runs against the Texas Rangers back on July 8, which was his last appearance. The Angels have a team ERA of 4.90, which ranks 28th.
Rockies Starting Freeland
Colorado enters play on Saturday with a record of 42-112 and won the first game of the series on Friday. The Rockies are set to start left-hander Kyle Freeland, who's 4-16 with a 5.14 ERA in 29 starts this season. In his last outing, he went 5.2 innings, allowing six runs against the Marlins. In his career against the Angels, Freeland is 2-0 with a 2.63 ERA. Colorado has a team ERA of 6.04, which ranks 30th.
The Rockies are hitting just .240, which ranks 23rd, while at home, they are hitting .272. In the month of September, they are hitting .244, and against left-handers, they are hitting .242.
Angels vs. Rockies Pick
Money Line Pick for Angels vs. Rockies
- Rockies ML (5 units)
Los Angeles and Colorado are both having disappointing seasons this year, but this is a great spot for the Rockies to get the win here. The Angels are starting Aldegheri, who has been shelled in his few appearances in the majors this season, as this should mostly be a bullpen game. Freeland, meanwhile, has been one of the few bright spots for Colorado as he's pitched decently and should be able to limit the damage while the Rockies get out to an early lead and cruise to a lopsided win here.
Take the Rockies ML.
Over/Under Pick for Angels vs. Rockies
- Over (5 units)
With this pitching matchup, the over is a great spot here as Colorado should be able to get after Aldegheri early, while Freeland will also give up some runs, as Coors Park is a great over spot. This season, the Angels are 83-65-6 in hitting the over, which is the second-best record in the majors, while Colorado is 40-37-2 in hitting the over at home. Look for those trends to continue, especially with this pitching matchup.