Los Angeles Angels vs. Milwaukee Brewers Picks and Prediction for Wednesday, September 17, 2025
The Los Angeles Angels (69-81, 80-64-6 O/U) will be taking on the Milwaukee Brewers (91-59, 71-73-6 O/U) on Wednesday evening in the middle game of a three-game interleague series for our Angels vs. Brewers prediction. This is being written ahead of Tuesday’s opening game of the series. Young right-hander Jose Soriano (10-10, 4.13 ERA) is going to be pitching in this game for the Angels while the Brewers are sending righty Brandon Woodruff (6-2, 3.32 ERA) to the hill. First pitch focus — MLB picks for the Los Angeles Angels vs. the Milwaukee Brewers that cut through the noise.
Angels Looking to Get a Win
The Los Angeles Angels are looking to play spoiler as they are fifth in the AL West with a 69-81 record up to this point. The offense is struggling a bit as they are tied with the San Francisco Giants for 21st in baseball with a .237/.312/.388 team slash line while averaging 4.24 runs per game.
The Los Angeles Angels are coming off an 11-2 road loss on Sunday to the Seattle Mariners and the team saw Christian Moore and Oswald Peraza each hit a home run. Kyle Hendricks struggled in a loss as he allowed nine runs in 3.1 innings.
Designated hitter Mike Trout (21 HR, .778 OPS) has been struggling compared to his career numbers, but still posting strong numbers. Young right-hander Jose Soriano (10-10, 4.13 ERA) is going to be on the mound and is coming off a no-decision against the Seattle Mariners where he allowed four runs (three earned) on five hits with one hit by pitch, three walks, and four strikeouts in four innings.
Injury Report for Los Angeles
- Third baseman Yoan Moncada: Ankle (Questionable)
- Shortstop Zach Neto: Hand (OUT)
- Catcher Travis d’Arnaud: Head (OUT)
- Pitcher Reid Detmers: Elbow (OUT)
- Pitcher Andrew Chafin: Triceps (OUT)
- Right fielder Jorge Soler: Back (OUT)
- Pitcher Ryan Zeferjahn: Knee (OUT)
- Pitcher Victor Mederos: Shoulder (OUT)
- Pitcher Carson Fulmer: Elbow (OUT)
- Right fielder Gustavo Campero: Ankle (OUT)
- Pitcher Tyler Anderson: Oblique (OUT)
- First baseman Nolan Schanuel: Wrist (OUT)
- Pitcher Hunter Strickland: Shoulder (OUT)
- Pitcher Ben Joyce: Shoulder (OUT)
- Third baseman Anthony Rendon: Hip (OUT)
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Brewers Looking to Capture Top NL Seed
The Milwaukee Brewers are doing a dominant job as they are first in the NL Central with a 91-59 record up to this point. The Brew Crew are hitting at a strong level as they are 10th in the bigs with a .743 team OPS while averaging 5.08 runs per game.
The Milwaukee Brewers are coming off a 3-2 home loss on Sunday to the St. Louis Cardinals and it does not help being 0-for-7 with runners in scoring position. Jose Quintana struggled as he allowed three runs in four innings of work.
Designated hitter Christian Yelich (29 HR, 16 SB) has been able to still be productive as a veteran in this lineup. Right-hander Brandon Woodruff (6-2, 3.32 ERA) will be taking the mound and is coming off a victory against the Pittsburgh Pirates, where he threw 6.0 shutout innings and gave up two hits with zero walks and eight strikeouts.
Injury Report for Milwaukee
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Nick Mears: Back Tightness (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
Angels vs/ Milwaukee Brewers Pick
Spread Pick for Los Angeles Angels vs. Milwaukee Brewers
- Milwaukee Brewers -1.5 (4 units)
When looking at the last seven starts for these pitchers, there is a gap as Jose Soriano is 3-2 with a 5.97 ERA and a 1.38 WHIP in 34.2 innings, while Brandon Woodruff is 4-2 with a 4.10 ERA and a 1.10 WHIP in 37.1 innings in that stretch. The batting average of balls in play shows a significant difference as the Angels are 28th with a .279 team BABIP while the Brew Crew are leading MLB with a .306 team batting average of balls in play. All in all, go with the Milwaukee Brewers to cover the run line in this game.
Over/Under Pick for Los Angeles Angels at Milwaukee Brewers
- Under (5 units)
The road/home splits show they are stepping up this year as Jose Soriano is 8-2 with a 2.66 ERA and a .233 batting average against in 91.1 innings (15 road starts) while Brandon Woodruff is 2-0 with a 3.67 ERA and a 1.07 WHIP in 27.0 innings (five home starts) heading into this game.. The under is 6-2-1 in their last nine games against one another, so take the under here.
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