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Los Angeles Angels vs Seattle Mariners Picks and Prediction for Friday, September 12, 2025

By: Arthur Reyes Published 09/12/2025, 11:08 AM ET
Los Angeles Angels vs Seattle Mariners Picks and Prediction for Friday, September 12, 2025

In our Angels vs. Mariners prediction, the Los Angeles Angels are fourth in the AL West with a 69-77 record so far. They are having veteran left-hander Yusei Kikuchi get the start as he is coming off a loss against the Athletics, where he pitched two innings and allowed seven runs on six hits with one hit by pitch, three walks, and one strikeout.

The Seattle Mariners are clicking as they are sitting in second place in the AL West with a 78-68 record entering this game. Right-hander Luis Castillo takes the ball and is coming off a victory over the Atlanta Braves, where he allowed one run on four hits with zero walks and six strikeouts in six innings of work.

Dial in your read with MLB picks for the Los Angeles Angels vs the Seattle Mariners before first pitch. WRITTEN BEFORE THURSDAY’S GAME

Angels Looking for Improvement

The Los Angeles Angels are looking to improve at the plate as the team is 22nd in the sport with a .705 team OPS while averaging 4.29 runs per game. Los Angeles has been struggling to steal bases as they are 23rd in the majors with 78 stolen bases on 103 tries. Center fielder Jo Adell has been hitting well as he has a .806 OPS with 35 home runs, 94 RBI, 57 runs scored, and five steals while being caught once.

Yusei Kikuchi has been struggling, according to his Baseball Savant page as he is in the seventh percentile in average exit velocity, 19th percentile in xERA, 23rd percentile in walk percentage, and 27th percentile in barrel percentage. He has a six-pitch arsenal (slider, fastball, curveball, changeup, sinker, sweeper) and his fastball has been getting hit the most as hitters have a .313 batting average and .505 slugging percentage with nine home runs and 54 strikeouts against it. Kikuchi faced the Mariners once this season in a loss as he pitched 4.2 innings and gave up three runs on seven hits with two walks and four strikeouts.

Injury Report for Los Angeles

  • Pitcher Reid Detmers: Elbow (OUT)
  • Catcher Logan O’Hoppe: Concussion (OUT)
  • Right fielder Jorge Soler: Back (OUT)
  • Pitcher Ryan Zeferjahn: Knee (OUT)
  • Pitcher Victor Mederos: Shoulder (OUT)
  • Pitcher Carson Fulmer: Elbow (OUT)
  • Right fielder Gustavo Campero: Ankle (OUT)
  • Pitcher Tyler Anderson: Oblique (OUT)
  • First baseman Nolan Schanuel: Wrist (OUT)
  • Pitcher Hunter Strickland: Shoulder (OUT)
  • Pitcher Ben Joyce: Shoulder (OUT)
  • Third baseman Anthony Rendon: Hip (OUT)

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Mariners Searching for Playoff Spot

The Seattle Mariners are doing a solid job at the plate as they are 12th in the bigs with a .734 team OPS while scoring 4.66 runs per game. The team has been hitting for a incredible amount of power as they are third with 213 total home runs hit. Catcher Cal Raleigh has been leading the way at the plate as he has a .241/.352/.573 slash line with 53 homers, 113 RBI, 95 runs scored, and 14 steals on 18 tries.

Luis Castillo is pitching poorly this season when diving into his Baseball Savant page, as he is in the sixth percentile in hard hit percentage, 11th percentile in average exit velocity, 13th percentile in barrel percentage, and 28th percentile in xBA. He has four different pitches (fastball, sinker, slider, changeup,) and his sinker has been struggling as hitters have a .324 batting average and .460 slugging percentage with four home runs and 17 strikeouts. Castillo faced the Angels once this season as he threw five innings and gave up six runs (four earned) on eight hits with zero walks and five strikeouts in a losing effort.

Injury Report for Seattle

  • Pitcher Jackson Kowar: Shoulder (OUT)
  • Pitcher Trent Thornton: Achilles (OUT)
  • Pitcher Logan Evans: Elbow (OUT)
  • Pitcher Gregory Santos: Knee (OUT)
  • Second baseman Ryan Bliss: Biceps (OUT)

Los Angeles Angels vs. Seattle Mariners Pick

Spread Pick for Los Angeles Angels vs. Seattle Mariners

  • Seattle Mariners ML (4 units)

There is a significant difference between these pitchers when looking at the road/home splits. Yusei Kikuchi is 1-8 with a 5.45 ERA and a .289 batting average against in 84.0 innings (15 road starts), while Luis Castillo is 4-4 with a 2.79 ERA and a 1.05 WHIP in 87.0 innings (15 home starts) right now. These bullpens are on two completely different levels, as the Angels are 28th with a 4.88 reliever ERA while the Mariners are 10th in the majors with a 3.73 bullpen ERA up to this point. Seattle has won three of the last five games against Los Angeles so take the Seattle Mariners to secure the victory.

Over/Under Pick for Los Angeles Angels vs. Seattle Mariners

  • OVER (5 units)

When diving into the previous seven starts for both pitchers, there is a struggle as Yusei Kikuchi is 2-4 with a 7.49 ERA and a 1.69 WHIP in 33.2 innings while Luis Castillo is 1-2 with a 6.29 ERA and a 1.49 WHIP in 34.1 innings of work. Both teams have been able to hit well in September as Los Angeles is 18th with a .704 team OPS while Seattle is fourth with a .818 team OPS so far. All in all, go with the OVER to hit in this game.

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