Los Angeles Angels vs Seattle Mariners Picks and Prediction for Thursday, September 24, 2026
The Los Angeles Angels and Seattle Mariners meet Thursday at T-Mobile Park for the first game of the final regular-season series for both teams, with the opening pitch scheduled for 9:40 PM ET and the game televised on MLB.TV. Los Angeles is 60-97, 26-50 away and fifth in the AL West, 18 games behind Houston and Texas. The Angels are eliminated from playoff contention and have lost two straight after Tuesday’s 9-7 defeat to the Athletics. Seattle is 73-84, 40-36 at home and third in the AL West, five games behind the division leaders. The Mariners lost 7-0 to Houston on Tuesday. Let’s break down the matchup with our free MLB picks.
Los Angeles Angels Trying to End a Two-Game Slide
Los Angeles is 2-3 across its last five games, with wins over Minnesota on September 17 and 19 followed by losses in two straight. Zach Neto leads the Angels with 26 home runs and 74 RBI while batting .238 with 23 stolen bases. Mike Trout is batting .245 with a .384 on-base percentage and .424 slugging percentage, along with 21 home runs and 53 RBI. Nolan Schanuel has a .276 average and .351 on-base percentage, while Vaughn Grissom has 12 homers and 68 RBI.
The Angels rank 26th in MLB with a .234 batting average and have scored 632 runs with 149 home runs, a .309 on-base percentage and .369 slugging percentage. Los Angeles ranks 20th in pitching with a 4.24 ERA, 1.34 WHIP and .238 opponent average. Angels pitchers have recorded 1,402 strikeouts while allowing 160 home runs in 1,388.1 innings. Los Angeles ranks 19th in fielding with 87 errors and a .984 fielding percentage and has gone 26-50 away from home.
Injuries: George Klassen (out), Nolan Schanuel (out), Kyren Paris (out), Samy Natera Jr. (out), Yoan Moncada (out).
Seattle Mariners Returning Home for the Final Series
Seattle is 3-2 across its last five games, although the Mariners are coming off Tuesday’s 7-0 loss to Houston. Randy Arozarena is batting .279 with a .379 on-base percentage and .480 slugging percentage while leading Seattle with 26 home runs and 76 RBI. Dominic Canzone has 22 home runs and 72 RBI with a .482 slugging percentage. Julio Rodriguez has recorded 21 homers, 66 RBI and 22 stolen bases, while Josh Naylor is batting .266 with 154 hits and 29 stolen bases.
The Mariners rank 29th in MLB with a .231 batting average and have scored 634 runs with 179 home runs, a .312 on-base percentage and .379 slugging percentage. Seattle’s pitching staff ranks 19th with a 4.21 ERA, 1.26 WHIP and .251 opponent average. Mariners pitchers have struck out 1,336 batters and allowed 190 home runs in 1,384.1 innings. Seattle ranks 17th in fielding with 84 errors and a .985 fielding percentage and owns a 40-36 record at T-Mobile Park.
Injuries: Andres Munoz (questionable), Brendan Donovan (out), Brennen Davis (out), Cole Wilcox (out), Will Wilson (out).
Pitching Matchup
Los Angeles Angels - Grayson Rodriguez
Grayson Rodriguez is 4-8 with a 5.96 ERA and 1.54 WHIP across 93.2 innings. He has allowed 106 hits and 15 home runs with 83 strikeouts and 38 walks.
Seattle Mariners - Bryan Woo
Bryan Woo is 12-9 with a 3.92 ERA and 1.08 WHIP across 167.2 innings. He has allowed 145 hits and 18 home runs with 167 strikeouts and 36 walks.
Los Angeles Angels vs Seattle Mariners Game Pick
- Seattle Mariners
Seattle is the pick with Woo holding the advantage in the starting matchup and the Mariners owning a 40-36 home record. Woo has a 3.92 ERA and 1.08 WHIP with 167 strikeouts against only 36 walks, while Rodriguez has a 5.96 ERA and 1.54 WHIP. Seattle has also won five of nine meetings with Los Angeles this season. The Angels are 26-50 away from home, and their .234 batting average and .369 slugging percentage create a difficult matchup against Seattle’s starter Woo.
Los Angeles Angels vs Seattle Mariners Over/Under Pick
- Over
The play is over with Rodriguez carrying a 5.96 ERA and 1.54 WHIP into the series opener. Seattle has struggled at the plate overall, but Arozarena, Canzone and Rodriguez have combined for 69 home runs, and the Mariners have hit 179 as a team. Los Angeles has also allowed 721 runs this season. The Angels have enough power from Neto and Trout to contribute against a Seattle staff with a 4.21 ERA, while Rodriguez’s numbers will help cash the total over.