Los Angeles Dodgers vs. Arizona Diamondbacks Picks and Prediction, Tuesday, September 23, 2025
An NL West matchup goes down on Tuesday, September 23, as the Los Angeles Angels take on the Arizona Diamondbacks at 9:40 p.m. ET, so continue reading for our Dodgers vs Diamondbacks prediction.
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Dodgers Starting Ohtani
Los Angeles is 88-68 and is in first place in the NL West. The Dodgers are coming off winning three of four against the Giants to get the series win. Los Angeles is hitting .254, which ranks fifth, while on the road, they are hitting .247. Against Pfaadt, Betts hits .500 in 18 ABs, Rojas is 2-for-4, Freeman hits .316 in 19 ABs with a homer, Kike Hernandez hits .375 in eight at-bats, with a homer, Ohtani hits .267 in 15 at-bats with a homer, and Conforto hits .250 in 12 at-bats with two homers.
The Dodgers are set to start right-hander Shohei Ohtani, who's 1-1 with a 3.29 ERA in 13 starts this season. In his last outing, he went five scoreless innings against the Phillies. Los Angeles has a team ERA of 4.02, which ranks 18th.
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Diamondbacks Chasing Wild Card Spot
Arizona enters play with a record of 79-77 and is one game back of a Wild Card spot. The Diamondbacks are coming off a series win over the Phillies. The Diamondbacks are set to start right-hander Brandon Pfaadt, who's 13-8 with a 5.02 ERA. He went nine scoreless innings against the Giants in his last outing, while against the Dodgers, he's 4-2 with a 5.11 ERA. Arizona has a team ERA of 4.43, which ranks 23rd.
The Diamondbacks are hitting .252, which ranks 9th, while at home, they are hitting .258. Against Ohtani, only Marte has faced him, who's 0-for-2. The Diamondbacks are also hitting .266 in the month of September.
Dodgers vs. Diamondbacks Pick
- Dodgers ML -163 (4 units)
Los Angeles is starting Ohtani, who's pitched well, as he should help the Dodgers get the win in the series opener on Tuesday. Ohtani should be able to limit the Diamondbacks' offense, while Los Angeles' offense has been hot and should be able to give Ohtani a lead by the time he leaves the game. Although the bullpen is an issue, Arizona will struggle to score runs, as Los Angeles will win the series opener.
Over/Under Pick for Dodgers vs. Diamondbacks
- Under 9 runs -120 (5 units)
The under is a great spot here as Ohtani and Pfaadt have both pitched well as of late and should be able to limit the runs. Both starters should go 5-6 innings, allowing only a run or two to help the under cash. This season, Los Angeles is 76-74-6 in hitting the under, while Arizona is 71-75-10, but this pitching matchup is a great spot for the under.
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