Los Angeles Dodgers vs Arizona Diamondbacks Prediction and Picks - September 24, 2025
Major League Baseball action on Wednesday evening, and we have a Los Angeles Dodgers vs Arizona Diamondbacks Prediction ready to rock and roll. Los Angeles has had another solid season as they are 88-69 on the year and lead the National League West by 1.5 games over the Padres. Arizona still has hopes of a playoff berth as they come in just one game out of the 3rd wildcard slot with a 79-77 record. Can the Diamondbacks keep their playoff hopes alive? Read on to see our Dodgers vs Diamondbacks prediction.
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The Pen Blows It Again
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Arizona stunned the Dodgers on Tuesday night, staging a comeback to win 5-4 via a walk-off single by Geraldo Perdomo in the ninth inning. The Dodgers had built a commanding 4–0 lead behind a dominant start from Shohei Ohtani, who threw six shutout innings while fanning eight and issuing no walks. Teoscar Hernández fueled the early surge with a homer and a two-run single. But once again, L.A.’s bullpen couldn’t hold the advantage: after Arizona chipped away in the late innings, the relievers surrendered the tying sac fly and the decisive hit in the final frame. The collapse exemplified a recurring issue for the Dodgers down the stretch, as their bullpen reliability remains in question.
Looking ahead to Wednesday, Los Angeles will rely on Blake Snell, who brings a 5–4 record and a strong 2.44 ERA into this matchup. Snell’s ability to miss bats and work efficiently gives the Dodgers a chance to regain control, especially against a Diamondbacks lineup that has shown inconsistency beyond big moments. His job will be to keep the game close deep into the innings so that the bullpen isn’t forced into a high-wire act. Offensively, the Dodgers will lean on their core hitters—Hernández, Freeman, and others—to stay aggressive but smart, especially early against Arizona’s starter.
For the Dodgers, the keys will be controlling the middle innings, limiting baserunners, and not handing momentum back via mistakes. If Snell gives them length and the bullpen can at least be competent, L.A. still has enough firepower offensively to challenge Arizona. But after Tuesday’s late collapse, this game takes on extra weight: it’s not just about winning, but about proving they can protect leads against a scrappy opponent. Adding to the urgency is the fact that Los Angeles holds just a 1.5-game lead over the Padres in the NL West, leaving little margin for error as the division race tightens heading into the final stretch.
Arizona Keeps Playoff Hopes Alive With Comeback Win
Down 4–0 entering the late innings on Tuesday, the Diamondbacks mounted a spirited rally to pull off a 5-4 walk-off win, keeping their playoff hopes alive. The comeback began in the seventh with a pinch-hit two-run homer by Adrian Del Castillo, and continued with a sacrifice fly by Jorge Barrosa in the ninth to tie it. Then Perdomo delivered with a two-out single to score Tim Tawa and complete the dramatic comeback. The victory showcased Arizona’s refusal to go quietly and their ability to seize opportunities late, a trait that has defined their season’s push.
On Wednesday, Arizona will counter with Ryne Nelson, who enters with a 7–3 record and a 3.34 ERA. Nelson has been one of their steadiest rotation options this year, showing poise in tight spots and the ability to limit big innings. Facing him will be Blake Snell, making this one of the more balanced matchups in the series. For Nelson, success will depend on commanding the strike zone, avoiding free passes, and keeping the Dodgers’ offense from breaking through early. The bullpen—revitalized by Tuesday’s finish—will be counted on to preserve whatever lead or deficit remains late in the game.
Offensively, Arizona will look to stay opportunistic. Their comeback mentality is loud in the clubhouse now, and players like Del Castillo, Barrosa, Ketel Marte, and Corbin Carroll provide multiple pathways to manufacturing runs. They’ll aim to press but also stay selective against Snell, hoping to force mistakes and capitalize on bullpen mismatches. Just as important, Arizona sits just a few games out in the NL Wild Card standings, and each win at this stage of the season carries weight not only for morale but also for postseason positioning. That urgency should keep the Diamondbacks locked in and dangerous throughout the night.
Los Angeles Dodgers vs Arizona Diamondbacks Pick
Dodgers vs Diamondbacks Moneyline Pick
- Los Angeles -150 (5 Units)
Backing the Dodgers at -150 on the moneyline makes sense given the matchup advantages on the mound. Blake Snell has been everything Los Angeles hoped for down the stretch, posting a sharp 2.44 ERA and holding opposing hitters to a low average with his swing-and-miss stuff. He also brings playoff-tested experience, which is valuable in a tight September race. Coming off Tuesday’s collapse, the Dodgers should be extra focused on protecting a lead, and Snell gives them the best chance to start strong and hand a winnable game to the bullpen. With stars like Shohei Ohtani, Freddie Freeman, and Teoscar Hernández producing, Los Angeles has the offensive firepower to pressure Ryne Nelson early and tilt the game in their favor.
For Arizona, Nelson has been solid this season, but facing this Dodgers lineup with Snell on the opposite side puts him in a tough spot. The Diamondbacks showed resilience in Tuesday’s rally, but relying on late-inning comebacks is not a sustainable formula against a pitcher of Snell’s caliber. Los Angeles still sits atop the NL West with only a 1.5-game cushion over San Diego, meaning this is effectively a must-win game to maintain breathing room. That added urgency, combined with their edge in the starting pitching matchup, makes the Dodgers a worthy play at -150 despite laying a bit of juice. This is a spot where their talent and motivation align.
Dodgers vs Diamondbacks Over/Under Pick
- Under 8.5 (5 Units)
The Under 8.5 looks appealing here given the quality of the pitching matchup and the stakes involved. Blake Snell has been lights out all year, consistently limiting damage and keeping games low-scoring, while Ryne Nelson has quietly put together a strong season of his own, showing the ability to work efficiently and avoid big innings. The Dodgers’ offense can explode, but they’re just as likely to grind out runs in a tight divisional game, and Arizona has relied more on timely hits than high run totals. With playoff implications on the line for both teams, expect a sharper, more focused game where runs come at a premium, making the Under 8.5 the right angle.
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