Los Angeles Dodgers vs. Seattle Mariners Picks and Prediction for Friday, September 26, 2025

Our Dodgers vs. Mariners prediction sees the Los Angeles Dodgers (90-69) getting ready to take on the Seattle Mariners (89-69) in interleague action at T-Mobile Park on Friday night in the opening game of a three-game series. The Dodgers were on the road on Thursday and defeated the Arizona Diamondbacks 8-0. This is being written before the Mariners finish their game on Thursday. Young right-hander Emmet Sheehan gets the start for the Dodgers while righty George Kirby pitches for the Mariners. Cover the diamond — MLB picks for the Los Angeles Dodgers vs. the Seattle Mariners in a fast read.

Dodgers Looking Sharp

The Los Angeles Dodgers are looking to build on their 8-0 road win on Thursday against the Arizona Diamondbacks to close out their series. The lineup was able to go 11-for-450 with four walks and 10 strikeouts as Freddie Freeman (x2) and Andy Pages hit a home run. Los Angeles was 2-for-8 with runners in scoring position and stranded nine men on base. Yoshinubo Yamamoto pitched well in the win as he threw six shutout innings.

Young righty Emmet Sheehan is getting the start for the Los Angeles Dodgers and has only 14 games (11 starts) this season. He is 6-3 with a 2.86 ERA and a 0.97 WHIP in 72.1 innings of work. He has been keeping the ball in the park as he allowed seven after giving up 11 in 60.1 innings of work. Sheehan faced the Mariners once in 2023 out of the bullpen, where he pitched three shutout innings and allowed one hit with zero walks and five strikeouts.

Injury Report for Los Angeles

• Pitcher Kirby Yates: Hamstring (OUT)
• Pitcher Michael Kopech: Knee (OUT)
• Catcher Will Smith: Hand (OUT)
• Pitcher Brock Stewart: Shoulder (OUT)
• Pitcher Tony Gonsolin: Elbow (OUT)
• Pitcher Evan Phillips: Forearm (OUT)
• Pitcher Kyle Hurt: Elbow (OUT)
• Pitcher Michael Grove: Shoulder (OUT)
• Pitcher Brusdar Graterol: Shoulder (OUT)
• Pitcher River Ryan: Elbow (OUT)
• Pitcher Gavin Stone: Shoulder (OUT)

Mariners Looking for AL West Crown

The Seattle Mariners are coming off a 9-2 home win on Wednesday against the Colorado Rockies last time out. The team was able to step up offensively as they were able to go 14-for-36 with one walk and eight strikeouts as a whole, with Cal Raleigh (x2), Julio Rodriguez, Jorge Polanco, and Eugenio Suarez all homered while Josh Naylor stole a base. Seattle was 3-for-8 with runners in scoring position and left six men on base. Luis Castillo pitched well in 7.1 innings he is allowing one run.

The Mariners are going to be sending right-hander George Kirby to the mound and he is currently 10-7 with a 4.24 ERA and a 1.21 WHIP in 121.0 innings. He has been able to limit the amount of hits against him as he has a .255 batting average against. Kirby faced the Dodgers in 2023 and lost as he pitched six innings and gave up four runs on five hits with one hit by pitch, two walks, and seven strikeouts.

Injury Report for Seattle

• Pitcher Bryan Woo: Pectoral (Questionable)
• Pitcher Jackson Kowar: Shoulder (OUT)
• Pitcher Trent Thornton: Achilles (OUT)
• Pitcher Logan Evans: Elbow (OUT)
• Pitcher Gregory Santos: Knee (OUT)
• Second baseman Ryan Bliss: Biceps (OUT)

Los Angeles Dodgers vs. Seattle Mariners Pick

Spread Pick for Dodgers vs. Mariners

• Los Angeles Dodgers ML (5 units)

When looking at the previous seven pitching appearances, there is a huge gap as Emmet Sheehan is 3-1 with a 2.76 ERA and a 0.80 WHIP in 42.1 innings (six starts) while George Kirby is 2-2 with a 5.50 ERA and a 1.53 WHIP in 36.0 innings (seven starts) in that span. Since the All-Star break, there is a bit of a difference as the Dodgers are seventh with a .759 team OPS in 62 games, while the Mariners are 10th with a .743 team OPS in their 62 games as well. The Dodgers have won the previous nine games against the Mariners so go with the Los Angeles Dodgers to secure another victory.

Over/Under Pick for Dodgers vs. Mariners

• Over ( units)

When diving into the offenses this season, Los Angeles is second with a .769 team OPS so far, while Seattle is 10th with a .744 team OPS right now. Since the All-Star break, these teams also have an incredible ability to dominate and hit home runs as the Dodgers are fifth with 94 home runs, while the Mariners are third with 100 homers hit. All in all, go with the over as the better bet for us to make here.