Milwaukee Brewers vs Pittsburgh Pirates Picks and Prediction for Saturday, September 6, 2025
Our Brewers vs. Pirates prediction sees the Milwaukee Brewers (87-55) getting ready to take on the Pittsburgh Pirates (64-78) in National League Central action at PNC Park on Saturday evening in the middle game of a three-game series. The Brewers won the opening game on Friday, 5-2. Right-hander Brandon Woodruff gets the start for the Brewers while righty Mitch Keller pitches for the Pirates. Today’s edge: MLB predictions for Milwaukee Brewers vs Pittsburgh Pirates with form and matchup notes.
Brewers Looking to Get Closer to NL Central Crown
The Milwaukee Brewers are coming off a 5-2 road win on Friday against the Pittsburgh Pirates last time out. The team did enough offensively as they were able to go 10-for-38 with five walks and eight strikeouts as on the day as Sal Frelick, Jake Bauers, and Caleb Durbin all stole a base. Milwaukee was only 3-for-20 with runners in scoring position and left 12 men on base. Quinn Priester pitched well as he allowed a pair of runs in seven innings of work to record the win.
The Brewers are going to be sending right-hander Brandon Woodruff to the mound and he is currently 5-2 with a 3.69 ERA and a 1.02 WHIP in 53.2 innings. He has done well throughout the season in terms of keeping the ball in the park, as he has allowed eight thus far after giving up nine over 67.0 innings in 2024. Woodruff faced the Pirates once earlier this season but did not factor into the decision as he pitched four shutout innings and allowed four hits with two walks and four strikeouts.
Injury Report for Milwaukee
- Left fielder Christian Yelich: Back (Questionable)
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Nick Mears: Back Tightness (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher Grant Anderson: Ankle (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- First baseman Rhys Hoskins: Thumb (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
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Pirates on the Attack
The Pittsburgh Pirates are looking to bounce back from their 5-2 home loss on Friday against the Milwaukee Brewers to begin their series. The lineup was able to go 6-for-32 with one walk and eight strikeouts as Oneil Cruz stole a base in the game. The team was 1-for-10 with runners in scoring position and stranded five on base. Johan Oviedo did not factor into the decision as he pitched five innings and allowed one run.
Right-hander Mitch Keller will be getting the start for the Pittsburgh Pirates and is holding ihis own as he is 6-13 with a 4.21 ERA and a 1.28 WHIP in 156.0 innings (28 starts) so far. Hitters are not doing too well as he has a .254 opposing batting average up to this point. Keller faced the Brew Crew twice this year already and is 0-1 in 10.0 innings and gave up seven runs on 15 hits with two walks and 12 strikeouts.
Injury Report for Pittsburgh
- Second baseman Ronny Simon: Shoulder (OUT)
- Right fielder Jack Suwinski: Groin (OUT)
- First baseman Endy Rodriguez: Elbow (OUT)
- First baseman Enmanuel Valdez: Shoulder (OUT)
- Pitcher Justin Lawrence: Elbow (OUT)
- Pitcher Jared Jones: Elbow (OUT)
Milwaukee Brewers vs Pittsburgh Pirates Pick
Spread Pick for Milwaukee Brewers vs. Pittsburgh Pirates
- Milwaukee Brewers -175 (5 units)
The previous seven starts for these pitchers show a large difference between these teams as Brandon Woodruff is 3-2 with a 4.58 ERA and a 1.23 WHIP in 37.1 innings, while Mitch Keller is 2-3 with a 6.97 ERA and a 1.74 WHIP in 31.0 innings of work. Hitting with runners in scoring position shows a significant gap as Milwaukee is eighth with a .777 team OPS with runners in scoring position, while Pittsburgh is tied for last place with the Chicago White Sox with a .678 team OPS in those opportunities. All in all, go with the Milwaukee Brewers to extend their six-game winning streak against the Pittsburgh Pirates.
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Over/Under Pick for Milwaukee Brewers vs. Pittsburgh Pirates
- Under (4 units)
The road/home splits this season on the mound show these starters could limit the amount of runs as Brandon Woodruff is 3-2 with a 3.71 ERA and a .198 opposing batting average in 26.2 innings (five road starts) while Mitch Keller is 3-8 with a 4.27 ERA and a 1.39 WHIP in 84.1 innings (15 home starts) this year. The bullpens are holding their own as the Brew Crew is 10th with a 3.82 reliever ERA while the Pirates are 17th with a 4.13 bullpen ERA so far. The under hit in three of the previous five games between the Brewers and Pirates, so take the under here.
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