Milwaukee Brewers vs. San Diego Padres Picks and Prediction for Wednesday, September 24, 2025
In the closing game of a three-game National League series, the Milwaukee Brewers are taking on the San Diego Padres inside Petco Park on Wednesday afternoon in our Brewers vs. Padres prediction. This article is being written before Tuesday’s game. The Brewers are first in the NL Central with a 95-62 record and are sending young right-hander Quinn Priester to the mound. The Padres are second in the NL West with an 86-71 record and have righty Dylan Cease getting the ball. From splits to bullpens, MLB predictions for the Milwaukee Brewers vs. the San Diego Padres highlight the edge.
Brewers Looking to Lock Up #1 Seed
The Milwaukee Brewers are looking to recover after their 5-4 road loss in 11 innings against the San Diego Padres on Monday. The lineup was able to go 7-for-39 with eight walks and 11 strikeouts on the day Caleb Durnin stole a base. The Brewers went 3-for-11 with runners in scoring position and stranded 12 men on base. Freddy Peralta held his own in the no-decision as he allowed a pair of runs in five innings.
The Brewers are sending young right-hander Quinn Priester to pitch and he is clicking as in 28 games (23 starts), he is 13-2 in 152.1 innings with a 3.25 ERA and a 1.21 WHIP. He has been struggling a bit with the ability to keep the ball in the park as he allowed 18 home runs. Priester last faced the Padres in 2023 as a member of the Pittsburgh Pirates as he allowed four runs on four hits with three walks and four strikeouts in 5.1 innings of work.
Injury Report for Milwaukee
- Catcher William Contreras: Hand (Questionable)
- Pitcher Brandon Woodruff: Lat (OUT)
- Pitcher Jose Quintana: Calf (OUT)
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
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Padres Looking to Win the NL West
The San Diego Padres are looking to build upon Monday’s 5-4 walk-off win against the Milwaukee Brewers in their most recent game. The Padres were able to go 9-for-39 with four walks and 10 strikeouts at the plate as Jose Iglesias hit a home run. San Diego finished 2-for-9 with runners in scoring position while leaving 11 men on base. Nick Pivetta did alright without factoring into the decision as he pitched 5.2 innings and allowed three runs.
Right-hander Dylan Cease is going to be taking the mound for the San Diego Padres in this game and has been struggling as he is 8-12 with a 4.64 ERA and a 1.32 WHIP in 163.0 innings over 31 starts. He has been doing a good job in terms of limiting the amount of hits, as he has allowed a .237 batting average against this year. Cease faced Milwaukee twice last season and was 1-0 in 10.2 innings and giving up five runs on eight hits with seven walks and 17 strikeouts.
Injury Report for San Diego
- Pitcher David Morgan: Shoulder (OUT)
- Pitcher Nestor Cortes: Elbow (OUT)
- Pitcher Jason Adam: Quad (OUT)
- Shortstop Xander Bogaerts: Foot (OUT)
- Pitcher Jhony Brito: Forearm (OUT)
- Pitcher Joe Musgrove: Elbow (OUT)
Milwaukee Brewers vs. San Diego Padres Pick
Spread Pick for Brewers vs. Padres
- Milwaukee Brewers ML (5 units)
When diving into the last seven starts for these pitchers, there is a gap as Quinn Priester is 2-0 with a 3.55 ERA and a 1.29 WHIP in 38.0 innings while Dylan Cease is 3-2 with a 5.08 ERA and a 19:38 walk-to-strikeout ratio in 33.2 innings. Throughout the season, these teams are on different levels offensively as the Brewers are tied with the Seattle Mariners for 10th with a .740 team OPS, while the Padres are 18th with a .709 team OPS up to this point. All in all, go with the Milwaukee Brewers to record the win in this game.
Over/Under Pick for Brewers vs. Padres
- Under (4 units)
When diving into the bullpens this season, they are dominating thus far. Milwaukee is 10th in MLB with a 3.71 bullpen ERA, while San Diego is first with a 3.05 reliever ERA right now. Neither team in September showed they can click offensively as a whole, with the Brew Crew being 12th with a .734 team OPS in their 19 games this month, while the Padres are 18th with a .705 team OPS in their 20 games in the calendar month. The under hit in three of the four games they have played against one another this seaso,n so take the under here.
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