Milwaukee Brewers vs San Francisco Giants Picks and Prediction for Wednesday, July 29, 2026

The Milwaukee Brewers visit the San Francisco Giants at Oracle Park in San Francisco, California, on Wednesday, July 29, 2026. The opening pitch is scheduled for 3:45 p.m. ET, with television coverage available on MLB.TV. Milwaukee enters the matchup at 66-40 overall and 30-20 on the road, while San Francisco is 45-61 overall with a 25-26 home record. Despite the significant difference between the teams’ records, ESPN Analytics gives the Giants a narrow 50.3% chance of winning compared with 49.7% for the Brewers. The game-time temperature is listed at 70 degrees. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers for Milwaukee and San Francisco

Milwaukee is scheduled to start Shane Drohan, who enters Wednesday with a 5-4 record, a 3.51 ERA, and a 1.20 WHIP across 82 innings. Drohan has allowed 75 hits and six home runs while recording 82 strikeouts against 23 walks. San Francisco counters with Logan Webb, who owns a 5-7 record, a 3.98 ERA, and a 1.12 WHIP through 113 innings. Webb has surrendered 98 hits and nine home runs while collecting 89 strikeouts and issuing 29 walks. Milwaukee’s starter owns the lower ERA, better record, and fewer home runs allowed, while San Francisco’s starter has the lower WHIP and has completed 31 more innings.

Milwaukee Looks to Reestablish Its Season-Long Advantage

The Brewers enter this contest with an excellent 66-40 overall record and a strong 30-20 mark away from home. Milwaukee has won three of its last five games, defeating Colorado by scores of 11-2 and 8-5 while also earning a 4-3 victory over New York. The Brewers’ two losses during this stretch were a 5-2 defeat against Colorado and a 3-0 loss to San Francisco. Milwaukee has scored at least four runs in three of its latest five games, but it was held scoreless in its most recent meeting with the Giants.

Milwaukee is batting .254 as a team with 535 runs, 913 hits, and 98 home runs. The Brewers have produced a .336 on-base percentage and a .400 slugging percentage. Their pitching staff owns an impressive 3.42 ERA and 1.16 WHIP while limiting opposing batters to a .219 average. Milwaukee pitchers have accumulated 1,033 strikeouts while issuing 333 walks. The Brewers have also recorded a 25-16 mark in day games.

The Brewers’ most significant strength is their pitching profile. Milwaukee holds substantial advantages over San Francisco in team ERA, WHIP, opponent batting average, strikeouts, and walks. The Brewers have also scored 96 more runs despite hitting 21 fewer home runs. Milwaukee’s .336 on-base percentage is another notable advantage, sitting 28 points above San Francisco’s mark. The concern is the recent 3-0 loss in this matchup, when the Brewers were unable to convert their broader statistical advantages into any scoring.

San Francisco Tries to Produce Another Home Victory

The Giants enter Wednesday with a 45-61 overall record and a nearly even 25-26 record at Oracle Park. San Francisco has won three of its last five games, including its recent 3-0 victory over Milwaukee. The Giants also defeated Los Angeles by scores of 9-2 and 7-6 in 10 innings. Their two losses during this period were a 4-3 defeat against Los Angeles and a 5-4 loss to Kansas City. Four of San Francisco’s latest five games were decided by three runs or fewer, including three one-run contests.

San Francisco carries a .252 team batting average with 439 runs, 911 hits, and 119 home runs. The Giants own a .308 on-base percentage and a .416 slugging percentage. Their pitching staff enters with a 4.34 ERA and a 1.34 WHIP while allowing opponents to bat .246. San Francisco pitchers have recorded 804 strikeouts and issued 390 walks. The Giants have compiled a 19-22 record in day games.

The clearest San Francisco advantage is its power production. The Giants have hit 119 home runs compared with Milwaukee’s 98, while their .416 slugging percentage also exceeds the Brewers’ .400 mark. San Francisco enters this game with three victories in its last four contests and recently held Milwaukee scoreless. However, the Giants trail the Brewers in overall record, home-and-road splits, runs scored, on-base percentage, ERA, WHIP, opponent batting average, strikeouts, and walks.

Milwaukee Brewers vs San Francisco Giants Picks and Prediction

Milwaukee Brewers vs San Francisco Giants Pick

• Pick: Milwaukee Brewers Moneyline

Milwaukee is the selection despite ESPN Analytics giving San Francisco the narrowest possible advantage. The Brewers own a 21-game advantage in the overall standings and have produced a winning 30-20 road record. Milwaukee also has the better starting ERA and decisive advantages in team ERA, WHIP, opponent batting average, strikeouts, and walks. San Francisco won the recent meeting 3-0 and has shown more home-run power, but Milwaukee’s stronger overall performance and run-prevention numbers support a road victory.

Milwaukee Brewers vs San Francisco Giants Total Pick

• Take the under if the total is set at 8.0.

I would lean under 8.0 because the recent meeting ended with San Francisco winning 3-0, while Milwaukee’s scheduled starter owns a 3.51 ERA and has allowed only six home runs through 82 innings. The Giants’ scheduled starter carries a solid 1.12 WHIP across 113 innings. Milwaukee also owns a 3.42 team ERA, a 1.16 WHIP, and a .219 opponent batting average. San Francisco has recently participated in several higher-scoring contests, but the supplied starting and team pitching numbers favor a controlled game.

Final Score Prediction: Milwaukee Brewers 4 – San Francisco Giants 3

This prediction was written before the completion of game play on Tuesday.