Milwaukee Brewers vs St. Louis Cardinals Picks and Prediction for Monday, July 6, 2026

By: Kim Smith Published 07/06/2026, 12:20 AM ET
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The Milwaukee Brewers and St. Louis Cardinals open an important divisional series on Monday, July 6, 2026, at Busch Stadium in St. Louis, Missouri. First pitch is scheduled for 7:45 PM with coverage available on MLB.TV. Milwaukee is a slight -115 moneyline favorite, while St. Louis is listed at -104. The Brewers are +141 on the -1.5 run line, while the Cardinals are -171 at +1.5. The total is set at 8 runs. Be sure to check out our free MLB picks for even more baseball predictions and betting analysis.

Starting Pitchers for Monday Night

Milwaukee is expected to send Shane Drohan to the mound. He enters the game with a 3-2 record, a 3.12 ERA, and a 1.23 WHIP over 57.2 innings. He has allowed 53 hits while striking out 59 batters, walking 18, and giving up five home runs. St. Louis is scheduled to counter with Dustin May, who owns a 5-6 record with a 4.80 ERA and a 1.27 WHIP across 84.1 innings. May has surrendered 83 hits while recording 78 strikeouts, issuing 24 walks, and allowing seven home runs.

Milwaukee Brings Strong Road Form into St. Louis

The Brewers enter Monday with the best record in this matchup at 55-33 overall, including an impressive 26-15 record away from home. Milwaukee has gone 3-2 over its last five games. The Brewers recently defeated Arizona twice, including a 3-2 victory in their most recent game, while also earning an extra-inning win earlier in the series. Their two losses during that stretch came against Arizona and Cincinnati.

Milwaukee has been productive on both sides of the ball this season. The Brewers own a .255 batting average while scoring 446 runs on 754 hits. They have hit 82 home runs with a .338 on-base percentage and a .398 slugging percentage. Their pitching staff has been outstanding, posting a 3.36 ERA and a 1.18 WHIP while limiting opponents to a .219 batting average. Milwaukee pitchers have also piled up 859 strikeouts compared to 289 walks.

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The Brewers have been especially effective because of their pitching consistency. Their staff owns the lowest ERA, the lowest opponent batting average, and the highest strikeout total between these two teams. Those numbers have helped Milwaukee maintain one of the best records in baseball despite not relying heavily on the home run.

St. Louis Looks to Keep Pace

The Cardinals come into the opener with a 47-40 overall record and a 23-21 mark at Busch Stadium. St. Louis has won three of its last five games, including impressive victories over Chicago and Atlanta before dropping its most recent contest against the Cubs. The Cardinals have shown the ability to respond well throughout this recent stretch, winning three games by a combined margin of 25 runs.

Offensively, St. Louis is batting .248 while scoring 399 runs on 718 hits this season. The Cardinals have connected for 98 home runs with a .325 on-base percentage and a .397 slugging percentage. Their pitching staff has recorded a 4.14 ERA and a 1.33 WHIP while allowing opponents to hit .252. St. Louis pitchers have struck out 647 batters and issued 288 walks.

One strength for the Cardinals has been their offensive balance. They have nearly reached the 100-home run mark while maintaining a solid batting average and on-base percentage. However, their pitching numbers trail Milwaukee in several categories, making run prevention an area to watch entering this matchup.

Milwaukee Brewers vs St. Louis Cardinals Picks and Prediction

Milwaukee Brewers vs St. Louis Cardinals Pick

  • Pick: Brewers Moneyline (-115)

Milwaukee enters with the better overall record, the stronger road record, and advantages across several important pitching categories. The Brewers also have the edge with the scheduled starting pitcher, whose ERA is more than a run lower than his counterpart's. With Milwaukee combining consistent pitching and a productive offense, I like the Brewers to begin the series with a victory.

Milwaukee Brewers vs St. Louis Cardinals Total Pick

  • Pick: Under 8

I'm backing the under 8 in this matchup. Milwaukee has posted an outstanding 3.36 team ERA while holding opponents to a .219 batting average, and its scheduled starter has been effective throughout the season. Although St. Louis has produced solid offensive numbers, I think Milwaukee's pitching gives this game a good chance to stay below the total.

Final Score Prediction: Milwaukee Brewers 4 – St. Louis Cardinals 3

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